Publications by authors named "Xavier de Leval"

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N-(3-Arylaminopyridin-4-yl)alkanesulfonamides as pyridine analogs of nimesulide: cyclooxygenases inhibition, anti-inflammatory studies and insight on metabolism.
Jean-François Renard, Frédéric Lecomte, Philippe Hubert, Xavier de Leval, Bernard Pirotte

Eur J Med Chem· March 2014

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Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors.
Jean-François Renard, Deniz Arslan, Nancy Garbacki, Bernard Pirotte, Xavier de Leval

J Med Chem· October 2009

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From the design to the clinical application of thromboxane modulators.
Jean-Michel Dogné, Julien Hanson, Xavier de Leval, Domenico Pratico, Cecil R Pace-Asciak

Curr Pharm Des· March 2007

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Structure-based pharmacophore of COX-2 selective inhibitors and identification of original lead compounds from 3D database searching method.
Catherine Michaux, Xavier de Leval, Fabien Julémont, Jean-Michel Dogné, Bernard Pirotte

Eur J Med Chem· December 2006

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Activation of the thromboxane A2 pathway in human prostate cancer correlates with tumor Gleason score and pathologic stage.
Thibaut Dassesse, Xavier de Leval, Laurence de Leval, Bernard Pirotte, Vincent Castronovo

Eur Urol· November 2006

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Evaluation of original dual thromboxane A2 modulators as antiangiogenic agents.
Xavier de Leval, Thibaut Dassesse, Jean-Michel Dogné, David Waltregny, Akeila Bellahcène

J Pharmacol Exp Ther· September 2006

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The use of nimesulide and its analogues in cancer chemoprevention.
Jean-Fran Ois Renard, Fabien Julémont, Xavier de Leval, Bernard Pirotte

Anticancer Agents Med Chem· May 2006

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Synthesis, molecular modelling and enzymatic evaluation of (+/-)3,5-diphenyl-2-thioxoimidazolidin-4-ones as new potential cyclooxygenase inhibitors.
Marie P Gauthier, Catherine Michaux, Stéphanie Rolin, Caroline Vastersaegher, Xavier de Leval

Bioorg Med Chem· February 2006

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A new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide.
Catherine Michaux, Caroline Charlier, Fabien Julémont, Xavier de Leval, Jean-Michel Dogné

Eur J Med Chem· December 2005

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Thromboxane A2 inhibition: therapeutic potential in bronchial asthma.
Jean-Michel Dogné, Xavier de Leval, Patricia Benoit, Jacques Delarge, Bernard Masereel

Am J Respir Med· May 2005

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Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.
Jean-Yves Winum, Jean-Michel Dogné, Angela Casini, Xavier de Leval, Jean-Louis Montero

J Med Chem· March 2005

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Effects of COX-2 inhibitors on ROS produced by Chlamydia pneumoniae-primed human promonocytic cells (THP-1).
Ange Mouithys-Mickalad, Ginette Deby-Dupont, Jean-Michel Dogne, Xavier de Leval, Stephan Kohnen

Biochem Biophys Res Commun· December 2004

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Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors.
Fabien Julémont, Xavier de Leval, Catherine Michaux, Jean-François Renard, Jean-Yves Winum

J Med Chem· December 2004

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First and second generations of COX-2 selective inhibitors.
Xavier de Leval, Fabien Julémont, Valérie Benoit, Michel Frederich, Bernard Pirotte

Mini Rev Med Chem· August 2004

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Recent development in the field of dual COX / 5-LOX inhibitors.
Fabien Julémont, Jean-Michel Dogné, Bernard Pirotte, Xavier de Leval

Mini Rev Med Chem· August 2004

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New developments on thromboxane modulators.
Jean-Michel Dogné, Julien Hanson, Xavier de Leval, Bernard Masereel, Philippe Kolh

Mini Rev Med Chem· August 2004

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Modulation of the arachidonic cascade with omega3 fatty acids or analogues: potential therapeutic benefits.
Isabelle Roland, Xavier De Leval, Brigitte Evrard, Bernard Pirotte, Jean-Michel Dogné

Mini Rev Med Chem· August 2004

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Pharmacological characterization of N-tert-butyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea (BM-573), a novel thromboxane A2 receptor antagonist and thromboxane synthase inhibitor in a rat model of arterial thrombosis and its effects on bleeding time.
Jean-Michel Dogné, Julien Hanson, Xavier de Leval, Philippe Kolh, Vincent Tchana-Sato, Laurence de Leval

J Pharmacol Exp Ther· May 2004

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New developments on thromboxane and prostacyclin modulators part I: thromboxane modulators.
Jean-Michel Dogné, Xavier de Leval, Julien Hanson, Michel Frederich, Bernard Lambermont

Curr Med Chem· May 2004

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New developments on thromboxane and prostacyclin modulators part II: prostacyclin modulators.
Xavier de Leval, Julien Hanson, Jean-Louis David, Bernard Masereel, Bernard Pirotte

Curr Med Chem· May 2004

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Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.
Xavier de Leval, Monica Ilies, Angela Casini, Jean-Michel Dogné, Andrea Scozzafava

J Med Chem· May 2004

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Progress in the field of GPIIb/IIIa antagonists.
Julien Hanson, Xavier de Leval, Jean-Louis David, Claudiu Supuran, Bernard Pirotte

Curr Med Chem Cardiovasc Hematol Agents· April 2004

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Spectral and crystallographic study of pyridinic analogues of nimesulide: determination of the active form of methanesulfonamides as COX-2 selective inhibitors.
Fabien Julémont, Xavier de Leval, Catherine Michaux, Jacques Damas, Caroline Charlier

J Med Chem· November 2002

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New trends in dual 5-LOX/COX inhibition.
Xavier de Leval, Fabien Julemont, Jacques Delarge, Bernard Pirotte, Jean-Michel Dogne

Curr Med Chem· May 2002

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Recent advances in antiplatelet agents.
Jean-Michel Dogne, Xavier de Leval, Patricia Benoit, Jacques Delarge, Bernard Masereel

Curr Med Chem· March 2002

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