Publications by authors named "Xian-Jun Qu"

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Activation of sphingosine-1-phosphate receptor 2 (S1PR2) upregulates dihydropyrimidine dehydrogenase (DPD) expression in colon cancer cells.
Zhi-Kun Guo, Xin-Feng Wu, Ming-Yong Tan, Wei-Shi Liang, Yu-Meng Yang, Xian-Jun Qu

J Adv Res· November 2025

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Conjugated bile acids promote metabolic dysfunction-associated steatotic liver disease through inducing nuclear translocation of sphingosine-1-phosphate receptor 2 to disrupt peroxisome proliferator-activated receptor alpha.
Rong-Rong Miao, Ming-Yong Tan, Han-Bing Shao, Zhi-Meng Sun, Sheng Zhan, Xian-Jun Qu

Cell Commun Signal· May 2025

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Inhibition of sphingosine-1-phosphate receptor-2 attenuates idiopathic pulmonary fibrosis by preventing its binding to dapper1 in bronchial epithelial cells.
Si-Yuan Mu, Rui Xu, Xin-Feng Wu, Yu-Yao Cheng, Zhi-Meng Sun, Xian-Jun Qu

Br J Pharmacol· April 2025

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Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting β-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis.
Juan Yang, Rong-Rong Miao, Ya-Nan Li, Ting Pan, Shu-Hua Wu, Xian-Jun Qu

Acta Pharmacol Sin· November 2022

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Intestinal aberrant sphingolipid metabolism shaped-gut microbiome and bile acids metabolome in the development of hepatic steatosis.
Rong-Rong Miao, Sheng Zhan, Shu-Xiang Cui, Xian-Jun Qu

FASEB J· August 2022

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Myricetin and M10, a myricetin-3-O-β-d-lactose sodium salt, modify composition of gut microbiota in mice with ulcerative colitis.
Rong-Rong Miao, Sheng Zhan, Xue-Tao Hu, Wen-Min Yuan, Li-Juan Wu, Xian-Jun Qu

Toxicol Lett· August 2021

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Nuclear translocation of ATG5 induces DNA mismatch repair deficiency (MMR-D)/microsatellite instability (MSI) via interacting with Mis18α in colorectal cancer.
Shi-Yue Sun, Xue-Tao Hu, Xin-Feng Yu, Yue-Ying Zhang, Xiao-Hui Liu, Xian-Jun Qu

Br J Pharmacol· June 2021

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Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation.
Yu-Hang Zhang, Shu-Xiang Cui, Sheng-Biao Wan, Shu-Hua Wu, Xian-Jun Qu

Acta Pharmacol Sin· March 2021

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Corrigendum to "S1PR2 inhibitors potently reverse 5-FU resistance by downregulating DPD expression in colorectal cancer" [Pharmacol Res. 155 (2020) 104717].
Yu-Hang Zhang, Dong-Dong Luo, Sheng-Biao Wan, Xian-Jun Qu

Pharmacol Res· September 2020

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M10, a Myricetin-3-O-b-D-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice.
Xiao-Ling Zhou, Juan Yang, Xian-Jun Qu, Jian Meng, Rong-Rong Miao

Front Pharmacol· September 2020

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SphK2 confers 5-fluorouracil resistance to colorectal cancer via upregulating H3K56ac-mediated DPD expression.
Yu-Hang Zhang, Wen-Na Shi, Shu-Hua Wu, Rong-Rong Miao, Shi-Yue Sun, Xian-Jun Qu

Oncogene· July 2020

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Metformin inhibited colitis and colitis-associated cancer (CAC) through protecting mitochondrial structures of colorectal epithelial cells in mice.
Shu-Qing Wang, Shu-Xiang Cui, Xian-Jun Qu

Cancer Biol Ther· May 2020

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S1PR2 inhibitors potently reverse 5-FU resistance by downregulating DPD expression in colorectal cancer.
Yu-Hang Zhang, Dong-Dong Luo, Sheng-Biao Wan, Xian-Jun Qu

Pharmacol Res· May 2020

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Correction: CXCR7/CXCR4 heterodimer-induced histone demethylation: a new mechanism of colorectal tumorigenesis.
Zhi-Yu Song, Feng Wang, Shu-Xiang Cui, Zu-Hua Gao, Xian-Jun Qu

Oncogene· July 2019

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Knockdown of IGF-1R Triggers Viral RNA Sensor MDA5- and RIG-I-Mediated Mitochondrial Apoptosis in Colonic Cancer Cells.
Shu-Qing Wang, Xiang-Yu Yang, Xin-Feng Yu, Shu-Xiang Cui, Xian-Jun Qu

Mol Ther Nucleic Acids· June 2019

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Heterozygous knockout insulin-like growth factor-1 receptor (IGF-1R) regulates mitochondrial functions and prevents colitis and colorectal cancer.
Shu Qing Wang, Xiang Yu Yang, Shu Xiang Cui, Zu Hua Gao, Xian Jun Qu

Free Radic Biol Med· April 2019

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CXCR7/CXCR4 heterodimer-induced histone demethylation: a new mechanism of colorectal tumorigenesis.
Zhi-Yu Song, Feng Wang, Shu-Xiang Cui, Zu-Hua Gao, Xian-Jun Qu

Oncogene· February 2019

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Natural dietary compound naringin prevents azoxymethane/dextran sodium sulfate-induced chronic colorectal inflammation and carcinogenesis in mice.
Yu-Sheng Zhang, Feng Wang, Shu-Xiang Cui, Xian-Jun Qu

Cancer Biol Ther· August 2018

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M10, a novel derivative of Myricetin, prevents ulcerative colitis and colorectal tumor through attenuating robust endoplasmic reticulum stress.
Feng Wang, Zhi-Yu Song, Xian-Jun Qu, Feng Li, Liang Zhang

Carcinogenesis· July 2018

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Chemopreventive effect of Myricetin, a natural occurring compound, on colonic chronic inflammation and inflammation-driven tumorigenesis in mice.
Mei-Jia Zhang, Han Su, Jing-Yue Yan, Na Li, Zhi-Yu Song, Xian-Jun Qu, Mei-Hua Qu

Biomed Pharmacother· January 2018

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Knockdown of CXCR4 Inhibits CXCL12-Induced Angiogenesis in HUVECs through Downregulation of the MAPK/ERK and PI3K/AKT and the Wnt/β-Catenin Pathways.
Zhi-Yu Song, Feng Wang, Shu-Xiang Cui, Xian-Jun Qu

Cancer Invest· January 2018

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Overexpression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of cytoplasmic RXRα by K48/K63-linked polyubiquitination.
Wen-Na Shi, Shu-Xiang Cui, Zhi-Yu Song, Shu-Qing Wang, Shi-Yue Sun, Xian-Jun Qu

Oncotarget· June 2017

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Roles and Signaling Pathways of Des-γ-Carboxyprothrombin in the Progression of Hepatocellular Carcinoma.
Shu-Xiang Cui, Xin-Feng Yu, Xian-Jun Qu

Cancer Invest· October 2016

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Chemoprevention of intestinal tumorigenesis by the natural dietary flavonoid myricetin in APCMin/+ mice.
Ye Li, Shu-Xiang Cui, Shi-Yue Sun, Wen-Na Shi, Zhi-Yu Song, Xian-Jun Qu

Oncotarget· September 2016

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Des-gamma-carboxy prothrombin antagonizes the effects of Sorafenib on human hepatocellular carcinoma through activation of the Raf/MEK/ERK and PI3K/Akt/mTOR signaling pathways.
Shu-Xiang Cui, Wen-Na Shi, Zhi-Yu Song, Shu-Qing Wang, Xin-Feng Yu, Xian-Jun Qu

Oncotarget· June 2016

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