Publications by authors named "Xiangduan Tan"

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Discovery of novel 1-(4-aminophenylacetyl)piperidine derivatives as FXR partial agonists for the potential treatment of metabolic dysfunction-associated steatohepatitis.
Bing Zhang, Jiaojiao Tu, Zhenghu Ban, Yanfen Peng, Yihuan Zhou, Xiangduan Tan

Eur J Med Chem· December 2025

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Discovery of farnesoid X receptor antagonists from Salvia miltiorrhiza based on virtual screening and activity verification.
Jiaojiao Tu, Wa Cheng, Zhenghu Ban, Jiayi Ning, Xiangduan Tan

Bioorg Med Chem Lett· August 2025

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Design, synthesis and FXR partial agonistic activity of anthranilic acid derivatives bearing aryloxy moiety as therapeutic agents for metabolic dysfunction-associated steatohepatitis.
Cong Chen, Xianghui Zhou, Wa Cheng, Xin Li, Bing Zhang, Xiangduan Tan

Bioorg Chem· December 2024

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Structure-activity relationships and pharmacokinetic evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria.
Longqin Hu, Haifa Albanyan, Jeffrey Yang, Xiangduan Tan, Yiling Wang

Med Chem Res· August 2024

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8-l-Cystinyl Bis(1,8-diazaspiro[4.5]decane) as an Orally Bioavailable l-Cystine Crystallization Inhibitor for Cystinuria.
Longqin Hu, Haifa Albanyan, Jeffrey Yang, Yiling Wang, Min Yang, Xiangduan Tan

ACS Med Chem Lett· July 2024

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Discovery of 4-aminophenylacetamide derivatives as intestine-specific farnesoid X receptor antagonists for the potential treatment of nonalcoholic steatohepatitis.
Cong Chen, Bing Zhang, Jiaojiao Tu, Yanfen Peng, Yihuan Zhou, Xiangduan Tan

Eur J Med Chem· January 2024

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Synthesis and biological evaluation of novel pentanediamide derivatives as S-adenosyl-l-homocysteine hydrolase inhibitors.
Yu-Bin Lv, Cong Chen, Qi-Ming Yu, Liang Lyu, Yan-Fen Peng, Xiang-Duan Tan

Bioorg Med Chem Lett· September 2022

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Identification of novel inhibitors of S-adenosyl-L-homocysteine hydrolase via structure-based virtual screening and molecular dynamics simulations.
Cong Chen, Xiang-Hui Zhou, Wa Cheng, Yan-Fen Peng, Qi-Ming Yu, Xiang-Duan Tan

J Mol Model· September 2022

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Discovery of novel N-aryl pyrrothine derivatives as bacterial RNA polymerase inhibitors.
Mo-Han Huang, Bo Kong, Jie-Yun Meng, Yu-Bin Lv, Yan-Fen Peng, Xiang-Duan Tan

Chem Biol Drug Des· November 2020

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Design, synthesis and biological evaluation of novel hybrids of N-aryl pyrrothine-base α-pyrone as bacterial RNA polymerase inhibitors.
Xiangduan Tan, Mohan Huang, Siyun Nian, Yanfen Peng, Jianli Qin

Bioorg Med Chem Lett· June 2020

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Anti-Hepatitis B Virus Activity of Esculetin from In Vitro and In Vivo.
Si-Xin Huang, Jun-Fei Mou, Qin Luo, Qing-Hu Mo, Xian-Li Zhou, Xiang-Duan Tan

Molecules· September 2019

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Synthesis and biological evaluation of novel SIPI-7623 derivatives as farnesoid X receptor (FXR) antagonists.
Si-Yun Nian, Guo-Ping Wang, Zheng-Li Jiang, Ying Xiao, Mo-Han Huang, Xiang-Duan Tan

Mol Divers· February 2019

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Discovery and Synthesis of a Novel Series of Liver X Receptor Antagonists.
Siyun Nian, Xia Gan, Xiangduan Tan, Zhenpeng Yu, Panfeng Wang

Chem Pharm Bull (Tokyo)· May 2016

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Design and synthesis of amide derivatives as S-adenosyl-L-homocysteine hydrolase inhibitors.
Xiangduan Tan, Panfeng Wang, Siyun Nian, Guoping Wang

Chem Pharm Bull (Tokyo)· August 2014

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Synthesis of substituted 6-amino-4-(2,4-dimethoxyphenyl)-[1,2]dithiolo[4,3-b]pyrrol-5-ones and their raising leukocyte count activities.
Xiangduan Tan, Chungang Li, Zhenpeng Yu, Panfeng Wang, Siyun Nian

Chem Pharm Bull (Tokyo)· December 2013

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