Publications by authors named "Xichen Lin"

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Novel associations between KCNQ1 rs231840 polymorphism and preeclampsia in Chinese gestational women: A case-control candidate genetic study.
Lingyu Ma, Rui Ma, Ran Ran, Jiaying Li, Xuefeng Pan, Xichen Lin

Medicine (Baltimore)· October 2024

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3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent.
Jeffrey K Kerns, Jakob Busch-Petersen, Wei Fu, Jeffrey C Boehm, Hong Nie, Guoliang Lin, Xichen Lin

ACS Med Chem Lett· December 2018

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Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists.
Hongfu Lu, Ting Yang, Zhongmiao Xu, Xichen Lin, Qian Ding

J Med Chem· March 2018

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From RORγt Agonist to Two Types of RORγt Inverse Agonists.
Yonghui Wang, Wei Cai, Ting Tang, Qian Liu, Ting Yang, Ling Zhou, Xichen Lin

ACS Med Chem Lett· February 2018

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Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders.
Heng Xu, Hongfu Lu, Zhongmiao Xu, Linbo Luan, Chengyong Li, Xichen Lin

ACS Med Chem Lett· April 2016

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Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent RORγt inverse agonists.
Yonghui Wang, Ting Yang, Qian Liu, Yingli Ma, Liuqing Yang, Ling Zhou, Xichen Lin

Bioorg Med Chem· September 2015

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Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors.
Yonghui Wang, Wei Cai, Yaobang Cheng, Ting Yang, Qian Liu, Ling Zhou, Xichen Lin

ACS Med Chem Lett· July 2015

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2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: discovery of novel and potent CXCR2 antagonists.
Hongfu Lu, Ting Yang, Zhongmiao Xu, Paul B Wren, Yueting Zhang, Xichen Lin

Bioorg Med Chem Lett· December 2014

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Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.
Sheng Xiao, Nir Yosef, Jianfei Yang, Yonghui Wang, Ling Zhou, Xichen Lin

Immunity· April 2014

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Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors.
Yonghui Wang, Wei Cai, Guifeng Zhang, Ting Yang, Qian Liu, Ling Zhou, Xichen Lin

Bioorg Med Chem· January 2014

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Discovery of Tertiary Amine and Indole Derivatives as Potent RORγt Inverse Agonists.
Ting Yang, Qian Liu, Yaobang Cheng, Wei Cai, Yingli Ma, Ling Zhou, Xichen Lin

ACS Med Chem Lett· January 2014

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Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors.
Guanghui Deng, Baowei Zhao, Yingli Ma, Qiongfeng Xu, Hailong Wang, Xichen Lin

Bioorg Med Chem· November 2013

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Identification of benzoxazole analogs as novel, S1P(3) sparing S1P(1) agonists.
Guanghui Deng, Qinghua Meng, Qian Liu, Xuesong Xu, Qiongfeng Xu, Xichen Lin

Bioorg Med Chem Lett· June 2012

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Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)).
Feng Ren, Guanghui Deng, Hailong Wang, Linbo Luan, Qinghua Meng, Xichen Lin

J Med Chem· May 2012

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Discovery of thiadiazole amides as potent, S1P₃-sparing agonists of sphingosine-1-phosphate 1 (S1P₁) receptor.
Heng Xu, Haibo Zhang, Linbo Luan, Yan Xu, Chengyong Li, Matthew Lindon, Xichen Lin

Bioorg Med Chem Lett· April 2012

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Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists.
Qinghua Meng, Baowei Zhao, Qiongfeng Xu, Xuesong Xu, Guanghui Deng, Linbo Luan, Xichen Lin

Bioorg Med Chem Lett· April 2012

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Explorations on the total synthesis of the unusual marine alkaloid chartelline A.
Cuixiang Sun, Xichen Lin, Steven M Weinreb

J Org Chem· April 2006

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