Publications by authors named "Xinuo Li"

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AI-driven discovery of dual antiaging and anti-AD therapeutics via PROTAC target deconvolution of a super-enhancer-regulated axis.
Yuan Sun, Sai Liu, Long Chen, Zheng Zhou, Xin Yin, Haotian Li, Jinran Li, Anbo Li, Xinuo Li

Sci Adv· November 2025

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Spaceflight redefines ageing-associated microbiota.
Yuan Sun, Sai Liu, Long Chen, Zheng Zhou, Mengyu Ma, Jinran Li, Philip M Williams, Xinuo Li

Imeta· June 2025

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Deep Learning-Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease.
Xinuo Li, Yuan Sun, Zheng Zhou, Jinran Li, Sai Liu

Adv Sci (Weinh)· May 2024

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Assessing Cannabidiol as a Therapeutic Agent for Preventing and Alleviating Alzheimer's Disease Neurodegeneration.
Long Chen, Yuan Sun, Jinran Li, Sai Liu, Hancheng Ding, Xinuo Li

Cells· November 2023

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Hydrocortisone Mitigates Alzheimer's-Related Cognitive Decline through Modulating Oxidative Stress and Neuroinflammation.
Jinran Li, Long Chen, Sai Liu, Yuan Sun, Le Zhen, Xinuo Li

Cells· September 2023

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Dual roles of demethylation in cancer treatment and cardio-function recovery.
Xinuo Li, Dehong Shen, Zheying Zhu, Dayin Lyu, Chang He, Jinran Li

Redox Biol· August 2023

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Asiaticoside Mitigates Alzheimer's Disease Pathology by Attenuating Inflammation and Enhancing Synaptic Function.
Sai Liu, Long Chen, Jinran Li, Yuan Sun, Yue Xu, Zhaoxing Li, Xinuo Li

Int J Mol Sci· July 2023

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Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer's disease.
Yuan Sun, Jinran Li, Nan A, Zhaoxing Li, Wenyi Zhong, Sai Liu, Xinuo Li

Front Immunol· May 2023

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Discovery of novel hybrids containing clioquinol-1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease.
Xinnan Li, Tiantian Li, Pengfei Zhang, Xinuo Li, Li Lu, Lisa White, James Phillips

Eur J Med Chem· December 2022

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Development of p-Tau Differentiated Cell Model of Alzheimer's Disease to Screen Novel Acetylcholinesterase Inhibitors.
Giuseppe Uras, Xinuo Li, Alessia Manca, Antonella Pantaleo, Marco Bo

Int J Mol Sci· November 2022

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New Insights into Neuroinflammation Involved in Pathogenic Mechanism of Alzheimer's Disease and Its Potential for Therapeutic Intervention.
Tiantian Li, Li Lu, Eloise Pember, Xinuo Li, Bocheng Zhang

Cells· June 2022

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Novel inhibitors of AChE and Aβ aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease.
Yulin Liu, Giuseppe Uras, Itse Onuwaje, Wenlong Li, Hong Yao, Xinuo Li, Xinnan Li, James Phillips, Jie Liu

Eur J Med Chem· May 2022

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Development of Alectinib-Based PROTACs as Novel Potent Degraders of Anaplastic Lymphoma Kinase (ALK).
Shaowen Xie, Yuan Sun, Yulin Liu, Xinnan Li, Xinuo Li

J Med Chem· July 2021

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Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease.
Hong Yao, Giuseppe Uras, Pengfei Zhang, Shengtao Xu, Ying Yin, Jie Liu, Xinuo Li

J Med Chem· June 2021

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Is the combinational administration of doxorubicin and glutathione a reasonable proposal?
Bo-Yu Shen, Chong Chen, Yang-Fan Xu, Jia-Jia Shen, Hui-Min Guo, Hao-Feng Li, Xi-Nuo Li, Lin Xie, Yan Liang

Acta Pharmacol Sin· May 2019

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Systematically identifying the hepatoprotective ingredients of schisandra lignan extract from pharmacokinetic and pharmacodynamic perspectives.
Dian Kang, Yuhao Shao, Zhangpei Zhu, Xiaoxi Yin, Boyu Shen, Haofeng Li, Xinuo Li, Lin Xie, Yan Liang

Phytomedicine· February 2019

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Activated charcoal significantly improved the reliability of methods for quantitative analysis of endogenous substances in biological specimens: Glutathione and cysteine as cases.
Boyu Shen, Chong Chen, Kangrui Hu, Xinuo Li, Dian Kang, Haofeng Li, Lin Xie, Yan Liang

J Chromatogr B Analyt Technol Biomed Life Sci· September 2018

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Pharmacokinetic and pharmacodynamic evidence for developing an oral formulation of octreotide against gastric mucosal injury.
Xi-Nuo Li, Tai Rao, Yang-Fan Xu, Kang-Rui Hu, Zhang-Pei Zhu, Hao-Feng Li, Lin Xie, Yan Liang

Acta Pharmacol Sin· August 2018

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[Determination of peptide antibiotics in animal food by capillary electrochromatography coupled with laser induced fluorescence].
Xiaoyun Lei, Yunping Song, Xinuo Li, Bingyu Zhang, Xiaoping Wu

Se Pu· March 2018

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Low Cerebral Exposure Cannot Hinder the Neuroprotective Effects of Panax Notoginsenosides.
Haofeng Li, Jingcheng Xiao, Xinuo Li, Huimin Chen, Dian Kang, Lin Xie, Yan Liang

Drug Metab Dispos· January 2018

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An integrated strategy for the quantitative analysis of endogenous proteins: A case of gender-dependent expression of P450 enzymes in rat liver microsome.
Yuhao Shao, Xiaoxi Yin, Dian Kang, Boyu Shen, Zhangpei Zhu, Xinuo Li, Haofeng Li, Lin Xie, Yan Liang

Talanta· August 2017

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Optimization and evaluation of MALDI TOF mass spectrometric imaging for quantification of orally dosed octreotide in mouse tissues.
Tai Rao, Boyu Shen, Zhangpei Zhu, Yuhao Shao, Dian Kang, Xinuo Li, Haofeng Li, Lin Xie, Yan Liang

Talanta· April 2017

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Pharmacokinetic study based on a matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight imaging mass microscope combined with a novel relative exposure approach: A case of octreotide in mouse target tissues.
Tai Rao, Yuhao Shao, Naoki Hamada, Yanmin Li, Hui Ye, Xinuo Li, Haofeng Li, Lin Xie, Yan Liang

Anal Chim Acta· February 2017

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Qualitatively and quantitatively investigating the regulation of intestinal microbiota on the metabolism of panax notoginseng saponins.
Jingcheng Xiao, Huimin Chen, Dian Kang, Yuhao Shao, Boyu Shen, Xinuo Li, Haofeng Li, Lin Xie, Yan Liang

J Ethnopharmacol· December 2016

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The metabolic and pharmacokinetic studies for HM-3 in rats based on LC-Q-TOF/MS and LC-MS/MS combing a convenient biological sample processing method.
Guangji Wang, Tai Rao, Yuhao Shao, Jingcheng Xiao, Dian Kang, Xinuo Li, Yan Liang

J Chromatogr B Analyt Technol Biomed Life Sci· September 2016

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