Publications by authors named "Xuben Hou"

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Discovery of benzimidazole-based Mcl-1 inhibitors via AlphaShape-enabled virtual screening.
Yiming Nie, Jintong Du, Xin Yan, Haihan Liu, Jiaqi Liu, Xuben Hou

Eur J Med Chem· January 2026

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Preclinical Characterization of SDFZ-8, a Highly Potent HDAC1 Inhibitor, for Cancer Immunotherapy.
Yi Zhou, Jintong Du, Xue Li, Huajun Zhao, Junxin Xue, Xuben Hou

MedComm (2020)· December 2025

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A novel ionizable lipid with comprehensive improvements in transfection potency, immune profile and safety of lipid nanoparticle.
Kun Guo, Lingling Bu, Jintong Du, Wei Zhang, Jiayuan Xia, Xuben Hou

J Control Release· October 2025

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Design, synthesis and evaluation of structural optimization derived HDAC6 isoform-selective inhibitor.
Chen Chen, Xiaochun Ma, Yichao Wan, Yidong Zhong, Xuben Hou

Bioorg Chem· July 2025

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Design and synthesis of novel benzoic acid derivatives as striatal-enriched protein tyrosine phosphatase (STEP) inhibitors with neuroprotective properties.
Chunxue Jiang, Renshuai Liu, Yong Chang, Shiji Zhang, Xue Li, Hengxing Zhou, Xuben Hou

Eur J Med Chem· February 2025

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Simultaneous inhibition of FLT3 and HDAC by novel 6-ethylpyrazine-2-Carboxamide derivatives provides therapeutic advantages in acute myelocytic leukemia.
Yingjie Chang, Xue Li, Yue Zhou, Xinying Yang, Wei Zhao, Xuben Hou

Eur J Med Chem· December 2024

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Discovery of a Novel Benzimidazole Derivative Targeting Histone Deacetylase to Induce Ferroptosis and Trigger Immunogenic Cell Death.
Meng Liu, Shan Gao, Yong Wang, Xinying Yang, Hao Fang, Xuben Hou

J Med Chem· September 2024

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Development of a First-in-Class DNMT1/HDAC Inhibitor with Improved Therapeutic Potential and Potentiated Antitumor Immunity.
Yingjie Chang, Huahui Guo, Xue Li, Liangyi Zong, Jiale Wei, Xuben Hou

J Med Chem· September 2024

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An in-line method for high-throughput screening of protein tyrosine phosphatase receptor type O inhibitors by capillary electrophoresis based on electrophoretically mediated microanalysis.
Xueting Qiu, Xuben Hou, Yue Yang, Hao Fang, Fei Cui

J Chromatogr A· January 2024

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Structural insight into TIPE1 functioning as a lipid transfer protein.
Sujian Cao, Ye Zhang, Haoqian Jiang, Xuben Hou, Wei Wang

J Biomol Struct Dyn· December 2023

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Discovery of benzofuran-2-carboxylic acid derivatives as lymphoid tyrosine phosphatase (LYP) inhibitors for cancer immunotherapy.
Xiao Liang, Huajun Zhao, Jintong Du, Xue Li, Kangshuai Li, Xuben Hou

Eur J Med Chem· October 2023

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Deciphering the Allosteric Activation Mechanism of SIRT6 Using Molecular Dynamics Simulations.
Zhiyuan Zhao, Jintong Du, Yu Du, Yuan Gao, Mingxuan Yu, Xuben Hou

J Chem Inf Model· September 2023

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Targeting histone deacetylases for cancer therapy: Trends and challenges.
Tao Liang, Fengli Wang, Reham M Elhassan, Yongmei Cheng, Xiaolei Tang, Xuben Hou

Acta Pharm Sin B· June 2023

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Design, synthesis and bioactivity evaluations of 8-substituted-quinoline-2-carboxamide derivatives as novel histone deacetylase (HDAC) inhibitors.
Yunpeng Zhao, Zefu Yao, Wandi Ren, Xinying Yang, Xuben Hou

Bioorg Med Chem· May 2023

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Characterization of an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase to treat Candida albicans infections.
Xueyang Jin, Xuben Hou, Xue Wang, Ming Zhang, Jinyao Chen

Cell Chem Biol· May 2023

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Interaction of PKR with STCS1: an indispensable step in the biosynthesis of lunularic acid in Marchantia polymorpha.
Ting-Ting Zhu, Chun-Jing Sun, Xin-Yan Liu, Jiao-Zhen Zhang, Xu-Ben Hou

New Phytol· January 2023

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Inhibition of fungal pathogenicity by targeting the HS-synthesizing enzyme cystathionine β-synthase.
Wenqiang Chang, Ming Zhang, Xueyang Jin, Haijuan Zhang, Hongbo Zheng, Xuben Hou

Sci Adv· December 2022

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Design, synthesis and biological evaluations of novel farnesoid X receptor (FXR) agonists.
Yuanju Zhu, Jay Zhang, Feng Min, Xinying Yang, Li Li, Xuben Hou

Bioorg Med Chem Lett· November 2022

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Structural basis of human SNAPc recognizing proximal sequence element of snRNA promoter.
Jianfeng Sun, Xue Li, Xuben Hou, Sujian Cao, Wenjin Cao

Nat Commun· November 2022

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Development of QSRR model for hydroxamic acids using PCA-GA-BP algorithm incorporated with molecular interaction-based features.
Yiming Nie, Jia Li, Xinying Yang, Xuben Hou, Hao Fang

Front Chem· November 2022

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Discovery of Novel Src Homology-2 Domain-Containing Phosphatase 2 and Histone Deacetylase Dual Inhibitors with Potent Antitumor Efficacy and Enhanced Antitumor Immunity.
Meng Liu, Shan Gao, Tao Liang, Xueting Qiu, Xinying Yang, Xuben Hou

J Med Chem· September 2022

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Structure-Based Design of 2-Aminopurine Derivatives as CDK2 Inhibitors for Triple-Negative Breast Cancer.
Hanzhi Liang, Yue Zhu, Zhiyuan Zhao, Jintong Du, Xinying Yang, Xuben Hou

Front Pharmacol· May 2022

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Design, synthesis and biological evaluation of hydantoin derivatives as Mcl-1 selective inhibitors.
Xiao Liang, Xue Li, Zhiyuan Zhao, Yiming Nie, Zefu Yao, Xuben Hou

Bioorg Chem· April 2022

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Palmarumycin P3 Reverses Mrr1-Mediated Azole Resistance by Blocking the Efflux Pump Mdr1.
Minghui Song, Ming Zhang, Jinghui Lu, Fei Xie, Jintong Song, Xuben Hou

Antimicrob Agents Chemother· March 2022

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Discovery of DNA-Targeting HDAC Inhibitors with Potent Antitumor Efficacy In Vivo That Trigger Antitumor Immunity.
Chen Chen, Xue Li, Huajun Zhao, Meng Liu, Jintong Du, Xuben Hou

J Med Chem· February 2022

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