Publications by authors named "Xueling Sim"

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Epigenome-Wide Association Study in Asian Cohort Identifies Novel DNA Methylation Markers for Carotid Intima-Media Thickness.
Konstanze Tan, Sarah E Harris, Jane Maddock, Darwin Tay, Pritesh R Jain, Xueling Sim, Simon R Cox

medRxiv· November 2025

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Association between plasma polyunsaturated fatty acids and metabolic syndrome risk: A prospective and mediation study in a multiethnic Asian population.
Yu Qi Lee, Bee Choo Tai, Xueling Sim, Rob M van Dam, Mary F-F Chong

Clin Nutr ESPEN· October 2025

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Development and Validation of Polygenic Scores for Retinal Vessel Calibers.
Chenglong Yu, Nuwanthi Rupasinghe, Liubov Robman, Lauren A B Hodgson, Thao Pham, Xueling Sim

Invest Ophthalmol Vis Sci· October 2025

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Substituting animal protein foods with plant protein foods influences vitamin B12 and folate statuses in a multiethnic Asian population.
Yu Qi Lee, Airu Chia, Xueling Sim, Rob M van Dam, Mary F-F Chong

Eur J Nutr· October 2025

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Circulating Proteomic Profiles Are Associated With Incident Type 2 Diabetes in Asian Populations.
Yujian Liang, Charlie G Y Lim, Scott C Ritchie, Nicolas Bertin, Jin-Fang Chai, Xueling Sim

J Clin Endocrinol Metab· September 2025

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Impact of polymorphisms on gene expression and splicing in response to exercise and diet-induced weight loss in human skeletal muscle tissues.
Wenjing Wang, Wei Lin Liew, Shiqi Huang, Edmund Chan, Amelia Li Min Tan, Xueling Sim

Cell Genom· September 2025

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Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Roelof A J Smit, Kaitlin H Wade, Qin Hui, Joshua D Arias, Xianyong Yin, Simon J Haworth, Massimo Mangino, Xueling Sim, Simona Vaccargiu, Eleanor M Simonsick, Mario Sims, Themistocles L Assimes

Nat Med· September 2025

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Factors affecting disease progression in early-stage chronic kidney disease in a multi-ethnic, southeast Asian primary care population.
Hui Qi Koh, Xueling Sim, Sky Wei Chee Koh

Front Med (Lausanne)· September 2025

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An empirical dietary inflammatory pattern increases the incidence of the metabolic syndrome in a multi-ethnic Asian population.
Naomi C Stemerdink, Evertine Wesselink, Jun Shi Lai, Jason Loh, Rob M van Dam, Xueling Sim

Eur J Nutr· August 2025

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Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.
Alicia Huerta-Chagoya, Joohyun Kim, Ravi Mandla, Yingchang Lu, Ken Suzuki, Simon Lee, Simin Liu, Xueling Sim

medRxiv· July 2025

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Vision transformer-based stratification of pre/diabetic and pre/hypertensive patients from retinal photographs for 3PM applications.
Krithi Pushpanathan, Yang Bai, Xiaofeng Lei, Jocelyn Hui Lin Goh, Can Can Xue, Xueling Sim

EPMA J· June 2025

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Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.
Amy R Bentley, Michael R Brown, Solomon K Musani, Karen L Schwander, Thomas W Winkler, Mario Sims, Xueling Sim

Transl Psychiatry· June 2025

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Interaction between polygenic risk score and reproductive factors in relation to lung cancer risk among Singaporean Chinese women.
Xin Yin, Jin Fang Chai, Gillianne Geet Yi Lai, Daniel Shao Weng Tan, Darren Wan-Teck Lim, Xueling Sim

Public Health· April 2025

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Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits.
Lauren E Petty, Hung-Hsin Chen, Elizabeth G Frankel, Wanying Zhu, Carolina G Downie, Xueling Sim

Nat Commun· April 2025

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Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline.
Yuqing Chen, Federico Torta, Hiromi W L Koh, Peter I Benke, Resham L Gurung, Xueling Sim

Diabetologia· March 2025

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Plasma Proteomic Signatures of Adiposity Are Associated With Cardiovascular Risk Factors and Type 2 Diabetes Risk in a Multiethnic Asian Population.
Charlie G Y Lim, Bige Ozkan, Yujian Liang, Jingsha Chen, Jiali Yao, Xueling Sim

Diabetes· March 2025

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Nuclear regulatory disturbances precede and predict the development of Type-2 diabetes in Asian populations.
Pritesh R Jain, Hong Kiat Ng, Darwin Tay, Theresia Mina, Dorrain Low, Sim Xueling

medRxiv· February 2025

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A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations.
Songmi Lee, Clint L Miller, Amy R Bentley, Michael R Brown, Pavithra Nagarajan, Simon R Cox, Xueling Sim

Res Sq· February 2025

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Proteomic analysis identifies novel biological pathways that may link dietary quality to type 2 diabetes risk: evidence from African American and Asian cohorts.
Charlie Gy Lim, Vlad Gradinariu, Yujian Liang, Casey M Rebholz, Sameera Talegawkar, Xueling Sim

Am J Clin Nutr· January 2025

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Diet, physical activity, and sleep in relation to postprandial glucose responses under free-living conditions: an intensive longitudinal observational study.
Jiali Yao, Victoria K Brugger, Sarah M Edney, E-Shyong Tai, Xueling Sim

Int J Behav Nutr Phys Act· December 2024

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A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes.
Joanna Hui Juan Tan, Zhihui Li, Mar Gonzalez Porta, Ramesh Rajaby, Weng Khong Lim, Xueling Sim

Nat Commun· November 2024

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Integrated clinical risk prediction of type 2 diabetes with a multifactorial polygenic risk score.
Scott C Ritchie, Henry J Taylor, Yujian Liang, Hasanga D Manikpurage, Lisa Pennells, Xueling Sim

medRxiv· September 2024

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Author Correction: Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes.
Jonathan P Bradfeld, Rachel L Kember, Anna Ulrich, Zhanna Balkhiyarova, Akram Alyass, Xueling Sim

Genome Biol· May 2024

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Characterizing the Relationship between Expression Quantitative Trait Loci (eQTLs), DNA Methylation Quantitative Trait Loci (mQTLs), and Breast Cancer Risk Variants.
Peh Joo Ho, Alexis Khng, Benita Kiat-Tee Tan, Chiea Chuen Khor, Ern Yu Tan, Xueling Sim

Cancers (Basel)· May 2024

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Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization.
Sara M Willems, Natasha H J Ng, Juan Fernandez, Rebecca S Fine, Eleanor Wheeler, Xueling Sim, Jennifer L Asimit

Wellcome Open Res· October 2023

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