Publications by authors named "Ya-Jen Chiu"

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Intrathecal STAT3 inhibitor Bt354 ameliorates chronic constriction injury-induced nociceptive sensitization by modulating neuroinflammation.
Hao-Jung Cheng, Nan-Fu Chen, Yueh-Chiao Tang, Po-Chang Shih, Wu-Fu Chen, Ya-Jen Chiu

Neurotherapeutics· October 2025

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The Neuroprotective Effects of the Crinoid Natural Compound Rhodoptilometrin in Parkinson's Disease Experimental Models: Implications for ER Stress and Autophagy Modulation.
Zhi-Hong Wen, Ya-Jen Chiu, San-Nan Yang, Bo-Lin Guo, Chien-Wei Feng

ACS Chem Neurosci· July 2025

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Indole and Coumarin Derivatives Targeting EEF2K in Aβ Folding Reporter Cells.
Shun-Tzu Chi, Pei-Cih Wei, Ya-Jen Chiu, Te-Hsien Lin, Chih-Hsin Lin, Chiung-Mei Chen

J Neurochem· January 2025

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Coumarin-chalcone derivatives as dual NLRP1 and NLRP3 inflammasome inhibitors targeting oxidative stress and inflammation in neurotoxin-induced HMC3 and BE(2)-M17 cell models of Parkinson's disease.
Te-Hsien Lin, Ya-Jen Chiu, Chih-Hsin Lin, Yi-Ru Chen, Wenwei Lin, Chiung-Mei Chen

Front Aging Neurosci· October 2024

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Soft Corals-derived Dihydrosinularin Attenuates Neuronal Apoptosis in 6-hydroxydopamine-induced Cell Model of Parkinson's Disease by Regulating the PI3K Pathway.
Zhi-Hong Wen, Ya-Jen Chiu, San-Nan Yang, Tzu-Yi Huang, Chien-Wei Feng

Curr Med Chem· September 2024

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A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment.
Ya-Jen Chiu, Yu-Shan Teng, Chiung-Mei Chen, Ying-Chieh Sun, Hsiu Mei Hsieh-Li

Biomol Ther (Seoul)· May 2023

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Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson's Disease.
Ya-Jen Chiu, Chih-Hsin Lin, Chung-Yin Lin, Pei-Ning Yang, Yen-Shi Lo, Chiung-Mei Chen

Int J Mol Sci· January 2023

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Using ΔK280 Tau Folding Reporter Cells to Screen TRKB Agonists as Alzheimer's Disease Treatment Strategy.
Zheng-Kui Weng, Te-Hsien Lin, Kuo-Hsuan Chang, Ya-Jen Chiu, Chih-Hsin Lin, Chiung-Mei Chen

Biomolecules· January 2023

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Neuroprotective Action of Coumarin Derivatives through Activation of TRKB-CREB-BDNF Pathway and Reduction of Caspase Activity in Neuronal Cells Expressing Pro-Aggregated Tau Protein.
Te-Hsien Lin, Kuo-Hsuan Chang, Ya-Jen Chiu, Zheng-Kui Weng, Ying-Chieh Sun, Chiung-Mei Chen

Int J Mol Sci· October 2022

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Novel TRKB agonists activate TRKB and downstream ERK and AKT signaling to protect Aβ-GFP SH-SY5Y cells against Aβ toxicity.
Ya-Jen Chiu, Te-Hsien Lin, Kuo-Hsuan Chang, Wenwei Lin, Hsiu Mei Hsieh-Li, Chiung-Mei Chen

Aging (Albany NY)· September 2022

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Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4-(Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2-Chromen-2-One Activates CREB-Mediated Neuroprotection in A and Tau Cell Models of Alzheimer's Disease.
Ya-Jen Chiu, Te-Hsien Lin, Chiung-Mei Chen, Chih-Hsin Lin, Yu-Shan Teng

Oxid Med Cell Longev· February 2022

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Multi-Target Effects of Novel Synthetic Coumarin Derivatives Protecting Aβ-GFP SH-SY5Y Cells against Aβ Toxicity.
Ching-Chia Huang, Kuo-Hsuan Chang, Ya-Jen Chiu, Yi-Ru Chen, Tsai-Hui Lung, Chiung-Mei Chen

Cells· November 2021

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Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement.
Ya-Jen Chiu, Chih-Hsin Lin, Ming-Chung Lee, Hsiu Mei Hsieh-Li, Chiung-Mei Chen

Aging (Albany NY)· June 2021

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Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation.
Ya-Jen Chiu, Shu-An Lin, Wan-Ling Chen, Te-Hsien Lin, Chih-Hsin Lin, Chiung-Mei Chen

Aging (Albany NY)· November 2020

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Exploration of multi-target effects of 3-benzoyl-5-hydroxychromen-2-one in Alzheimer's disease cell and mouse models.
Te-Hsien Lin, Ya-Jen Chiu, Chih-Hsin Lin, Chung-Yin Lin, Chih-Ying Chao, Chiung-Mei Chen

Aging Cell· July 2020

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Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer's Disease Cell and Mouse Models for Neuroprotection and Cognitive Improvement.
Yi-Chun Chen, Ya-Jen Chiu, Chih-Hsin Lin, Wen-Chuin Hsu, Jia-Lu Wu, Chiung-Mei Chen

J Alzheimers Dis· March 2020

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Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease.
Ya-Jen Chiu, Yu-Hsuan Hsieh, Te-Hsien Lin, Guan-Chiun Lee, Hsiu Mei Hsieh-Li, Chiung-Mei Chen

Neurochem Int· May 2019

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Novel synthetic chalcone-coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection.
Shin-Ying Lee, Ya-Jen Chiu, Shu-Mei Yang, Chiung-Mei Chen, Chin-Chang Huang

CNS Neurosci Ther· December 2018

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Chinese Herbal Medicine Glycyrrhiza inflataReduces Aβ Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.
Ya-Jen Chiu, Chi-Mei Lee, Te-Hsien Lin, Hsuan-Yuan Lin, Shin-Ying Lee, Chiung-Mei Chen

Am J Chin Med· October 2018

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The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity.
Kuo-Hsuan Chang, Ya-Jen Chiu, Shu-Ling Chen, Chen-Hsiang Huang, Chih-Hsin Lin

Neuropharmacology· February 2016

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