Publications by authors named "Yakov Koen"

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Comparative Toxicity and Metabolism of N-Acyl Homologues of Acetaminophen and Its Isomer 3'-Hydroxyacetanilide.
Yakov M Koen, Ke Liu, Heather Shinogle, Todd D Williams, Robert P Hanzlik

Chem Res Toxicol· November 2016

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Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes.
Jennifer L Goldman, Yakov M Koen, Steven A Rogers, Kelin Li, James S Leeder

Drug Metab Dispos· October 2016

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Protein Targets of Isoniazid-Reactive Metabolites in Mouse Liver in Vivo.
Yakov M Koen, Nadezhda A Galeva, Imir G Metushi, Jack Uetrecht, Robert P Hanzlik

Chem Res Toxicol· June 2016

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Bioinformatic analysis of 302 reactive metabolite target proteins. Which ones are important for cell death?
Robert P Hanzlik, Yakov M Koen, Jianwen Fang

Toxicol Sci· October 2013

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Protein targets of thioacetamide metabolites in rat hepatocytes.
Yakov M Koen, Diganta Sarma, Heather Hajovsky, Nadezhda A Galeva, Todd D Williams

Chem Res Toxicol· April 2013

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Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites.
Diganta Sarma, Heather Hajovsky, Yakov M Koen, Nadezhda A Galeva, Todd D Williams

Chem Res Toxicol· September 2012

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Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes.
Heather Hajovsky, Gang Hu, Yakov Koen, Diganta Sarma, Wenqi Cui

Chem Res Toxicol· September 2012

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Liver protein targets of hepatotoxic 4-bromophenol metabolites.
Yakov M Koen, Heather Hajovsky, Ke Liu, Todd D Williams, Nadezhda A Galeva

Chem Res Toxicol· August 2012

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Identification of protein targets of reactive metabolites of tienilic acid in human hepatocytes.
Yakov M Koen, Diganta Sarma, Todd D Williams, Nadezhda A Galeva, R Scott Obach

Chem Res Toxicol· May 2012

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Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners.
Jianwen Fang, Yakov M Koen, Robert P Hanzlik

BMC Chem Biol· June 2009

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Filling and mining the reactive metabolite target protein database.
Robert P Hanzlik, Jianwen Fang, Yakov M Koen

Chem Biol Interact· April 2009

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Protein targets of reactive metabolites of thiobenzamide in rat liver in vivo.
Keisuke Ikehata, Tatyana G Duzhak, Nadezhda A Galeva, Tao Ji, Yakov M Koen

Chem Res Toxicol· July 2008

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Covalent modification of microsomal lipids by thiobenzamide metabolites in vivo.
Tao Ji, Keisuke Ikehata, Yakov M Koen, Steven W Esch, Todd D Williams

Chem Res Toxicol· April 2007

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A proteomic analysis of bromobenzene reactive metabolite targets in rat liver cytosol in vivo.
Yakov M Koen, Natalia V Gogichaeva, Michail A Alterman, Robert P Hanzlik

Chem Res Toxicol· March 2007

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The reactive metabolite target protein database (TPDB)--a web-accessible resource.
Robert P Hanzlik, Yakov M Koen, Bhargav Theertham, Yinghua Dong, Jianwen Fang

BMC Bioinformatics· March 2007

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Site-specific arylation of rat glutathione s-transferase A1 and A2 by bromobenzene metabolites in vivo.
Yakov M Koen, Weimin Yue, Nadezhda A Galeva, Todd D Williams, Robert P Hanzlik

Chem Res Toxicol· November 2006

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Use of isotopic signatures for mass spectral detection of protein adduction by chemically reactive metabolites of bromobenzene: studies with model proteins.
Weimin Yue, Yakov M Koen, Todd D Williams, Robert P Hanzlik

Chem Res Toxicol· November 2005

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1H high-resolution magic-angle spinning (HR-MAS) NMR analysis of ligand density on resins using a resin internal standard.
Laura H Lucas, Matthew A Cerny, Yakov M Koen, Robert P Hanzlik, Cynthia K Larive

Anal Bioanal Chem· October 2004

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Synthesis of N tau-arylhistidine derivatives via direct N-arylation.
Weimin Yue, Stefanie I Lewis, Yakov M Koen, Robert P Hanzlik

Bioorg Med Chem Lett· April 2004

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Direct identification of cytochrome P450 isozymes by matrix-assisted laser desorption/ionization time of flight-based proteomic approach.
Nadezhda Galeva, Dmitry Yakovlev, Yakov Koen, Tatyana Duzhak, Michail Alterman

Drug Metab Dispos· April 2003

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Formation of cyclopropanone during cytochrome P450-catalyzed N-dealkylation of a cyclopropylamine.
Christopher L Shaffer, Shawn Harriman, Yakov M Koen, Robert P Hanzlik

J Am Chem Soc· July 2002

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Identification of seven proteins in the endoplasmic reticulum as targets for reactive metabolites of bromobenzene.
Yakov M Koen, Robert P Hanzlik

Chem Res Toxicol· May 2002

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