Publications by authors named "Yasuhiro Uno"

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Novel cytochrome P450 2J isoforms in tree shrews are functional drug-metabolising enzymes involved in ebastine and astemizole oxidation.
Yasuhiro Uno, Miu Kamizono, Genki Ushirozako, Kyoko Tsukiyama-Kohara, Norie Murayama

Xenobiotica· January 2026

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Genetic variants of cytochrome P450 2C21 identified by screening 6344 dogs influenced oxidations of the probe drug omeprazole.
Yasuhiro Uno, Koya Fukunaga, Genki Ushirozako, Norie Murayama, Keijiro Mizukami

Biochem Pharmacol· December 2025

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Genetic variants in dog cytochrome P450 2B6 and their relevance to interindividual variability of oxidations of probe drug propofol.
Yasuhiro Uno, Koya Fukunaga, Genki Ushirozako, Norie Murayama, Keijiro Mizukami

Drug Metab Dispos· December 2025

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Triethylamine N-oxygenation mediated by liver and kidney microsomes and recombinant flavin-containing monooxygenase 3 (FMO3) and FMO1 proteins from humans, monkeys, pigs, and dogs.
Makiko Shimizu, Anna Nii, Yasuhiro Uno, Hiroshi Yamazaki

Drug Metab Dispos· September 2025

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Investigation of genetic polymorphisms in pig cytochromes P450 1A2, 2A19, 2C33, 2D25, and 3A22 to elucidate inter-individual variability of hepatic drug oxidations.
Yasuhiro Uno, Genki Ushirozako, Norie Murayama, Hiroshi Yamazaki

Biochem Pharmacol· August 2025

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Exploration of functional cytochrome P450 4F enzymes in liver, intestine, and kidney from dogs, cats, pigs, and tree shrews and comparison of their metabolic capacities with human P450 4F2 and 4F12.
Yasuhiro Uno, Izumi Kawabata, Genki Ushirozako, Kyoko Tsukiyama-Kohara, Mayumi Ishizuka

Biochem Pharmacol· June 2025

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Novel dog hepatic cytochrome P450 3A293 oxidizes endogenous testosterone and estradiol.
Yasuhiro Uno, Genki Ushirozako, Norie Murayama, Hiroshi Yamazaki

Biochem Pharmacol· May 2025

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Identification of cytochrome P450 2C18 and 2C76 in tree shrews: P450 2C18 effectively oxidizes typical human P450 2C9/2C19 chiral substrates warfarin and omeprazole with less stereoselectivity.
Yasuhiro Uno, Yuhki Minami, Kyoko Tsukiyama-Kohara, Norie Murayama, Hiroshi Yamazaki

Biochem Pharmacol· October 2024

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A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models.
Yasuhiro Uno, Makiko Shimizu, Hiroshi Yamazaki

Biochem Pharmacol· October 2024

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Investigation of Functional Cytochrome P450 4A Enzymes in Liver and Kidney of Pigs, Cats, Tree Shrews, and Dogs in Comparison with the Metabolic Capacity of Human P450 4A11.
Yasuhiro Uno, Kyoko Tsukiyama-Kohara, Mayumi Ishizuka, Hazuki Mizukawa, Norie Murayama

Drug Metab Dispos· August 2024

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Quinuclidine -Oxygenation Mediated by Flavin-Containing Monooxygenases 1 and 3 in Kidney and Liver Microsomes from Humans, Monkeys, Dogs, and Pigs.
Makiko Shimizu, Miaki Makiguchi, Yasuhiro Uno, Hiroshi Yamazaki

Drug Metab Dispos· July 2024

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Transcript abundance of hepatic drug-metabolizing enzymes in two dog breeds compared with 14 species including humans.
Yasuhiro Uno, Osamu Yamato, Hiroshi Yamazaki

Drug Metab Pharmacokinet· April 2024

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Molecular and functional characterization of flavin-containing monooxygenases (FMO1-6) in tree shrews.
Yasuhiro Uno, Miaki Makiguchi, Genki Ushirozako, Kyoko Tsukiyama-Kohara, Makiko Shimizu

Comp Biochem Physiol C Toxicol Pharmacol· March 2024

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Novel Tree Shrew Cytochrome P450 2Ds (CYP2D8a and CYP2D8b) Are Functional Drug-Metabolizing Enzymes that Metabolize Bufuralol and Dextromethorphan.
Genki Ushirozako, Norie Murayama, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki, Yasuhiro Uno

Drug Metab Dispos· March 2024

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Habu snakes (Protobothrops flavoviridis) show variation in thoracic aortic vasoreactivity between adjacent Japanese islands.
Tomoki Ootawa, Siyuan Wu, Ryoya Sekio, Henry Smith, Md Zahorul Islam, Yasuhiro Uno

J Vet Med Sci· February 2024

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Novel Cytochrome P450 2C119 Enzymes in Cynomolgus and Rhesus Macaques Metabolize Progesterone, Diclofenac, and Omeprazole.
Yasuhiro Uno, Norie Murayama, Hiroshi Yamazaki

Drug Metab Dispos· February 2024

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Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation.
Yasuhiro Uno, Shotaro Uehara, Genki Ushirozako, Norie Murayama, Hiroshi Suemizu

Xenobiotica· December 2023

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Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and -nitrophenol.
Genki Ushirozako, Norie Murayama, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki, Yasuhiro Uno

Xenobiotica· December 2023

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Chronic infection affects gene expression of drug-metabolizing enzymes in mouse liver.
Yasuhiro Uno, Shotaro Uehara, Genki Ushirozako, Tatsunori Masatani, Hiroshi Yamazaki

Xenobiotica· December 2023

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Characterization of Vasoreactivity in a Semi-Arboreal Snake, the Tokara Habu ().
Tomoki Ootawa, Siyuan Wu, Ryoya Sekio, Henry Smith, Md Zahorul Islam, Yasuhiro Uno

Animals (Basel)· November 2023

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Reduced Nitric Oxide Synthase Involvement in Aigamo Duck Basilar Arterial Relaxation.
Siyuan Wu, Tomoki Ootawa, Ryoya Sekio, Henry Smith, Md Zahorul Islam, Yasuhiro Uno

Animals (Basel)· August 2023

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Involvement of beta-adrenergic receptors in relaxation mediated by nitric oxide in chicken basilar artery.
Siyuan Wu, Tomoki Ootawa, Ryoya Sekio, Henry Smith, Md Zahorul Islam, Yasuhiro Uno

Poult Sci· June 2023

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Newly identified cytochrome P450 3A genes of tree shrews and pigs are expressed and encode functional enzymes.
Yasuhiro Uno, Shiori Jikuya, Yutaro Noda, Asuka Oguchi, Norie Murayama

Comp Biochem Physiol C Toxicol Pharmacol· May 2023

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Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs.
Yasuhiro Uno, Yutaro Noda, Saho Morikuni, Norie Murayama, Hiroshi Yamazaki

Xenobiotica· March 2023

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2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A22.
Yasuhiro Uno, Saho Morikuni, Norie Murayama, Hiroshi Yamazaki

Xenobiotica· January 2023

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