Publications by authors named "Yew-Min Tzeng"

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Erratum: Ovatodiolide triggers ferroptosis in high-grade serous ovarian cancer through HMOX1 upregulation.
Yew-Min Tzeng, Aye Aye Khine, Hsuan-Shun Huang, Tang-Yuan Chu

Mol Ther Oncol· December 2025

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Antrocinol-mediated downregulation of ATG5 induces autophagy-dependent cell death and activates the unfolded protein response through PERK/CHOP signaling in lenvatinib-resistant hepatocellular carcinoma cells.
Shiue-Wei Lai, Yi-Chiao Cheng, Ming-Shou Hsieh, Kuang-Tai Kuo, Vijesh Kumar Yadav, Yew-Min Tzeng

Eur J Pharmacol· November 2025

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Ovatodiolide triggers ferroptosis in high-grade serous ovarian cancer through HMOX1 upregulation.
Yew-Min Tzeng, Aye Aye Khine, Hsuan-Shun Huang, Tang-Yuan Chu

Mol Ther Oncol· September 2025

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Ovatodiolide inhibits endometrial cancer stemness via reactive oxygen species-mediated DNA damage and cell cycle arrest.
Chun-Yu Chen, Yu-Zhen Ye, Yu-Hao Huang, Yew-Min Tzeng, Ranal Gurbanov

Chem Biol Interact· November 2024

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Targeting the Neuropilin-1 receptor with Ovatodiolide and progress in using periodontal ligament organoids for COVID-19 research and therapy.
Ming-Shou Hsieh, Ming-Yao Chen, Yu-Sheng Chang, Chin-Sheng Huang, Tung-Nien Hsu, Yew-Min Tzeng

Life Sci· August 2024

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Anti-Oxidant, Anti-Mutagenic Activity and Safety Evaluation of Antrocin.
Yi-Hui Su, Jia-Shuan Wu, Yan-Zhen Dai, Yng-Tay Chen, Yan-Xiu Lin, Yew-Min Tzeng

Toxics· June 2023

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Ovatodiolide and antrocin synergistically inhibit the stemness and metastatic potential of hepatocellular carcinoma via impairing ribosome biogenesis and modulating ERK/Akt-mTOR signaling axis.
Ming-Yao Chen, Chia-Hung Hsu, Syahru Agung Setiawan, David T W Tzeng, Hon-Ping Ma, Yew-Min Tzeng

Phytomedicine· January 2023

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Therapeutic targeting of hepatocellular carcinoma cells with antrocinol, a novel, dual-specificity, small-molecule inhibitor of the KRAS and ERK oncogenic signaling pathways.
Chia-Hung Hsu, Pei-Wei Weng, Ming-Yao Chen, Chi-Tai Yeh, Syahru Agung Setiawan, David T W Tzeng, Yew-Min Tzeng

Chem Biol Interact· January 2023

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Identification and semisynthesis of (-)-anisomelic acid as oral agent against SARS-CoV-2 in mice.
Hai-Xin Yu, Nan Zheng, Chi-Tai Yeh, Chien-Ming Lee, Qi Zhang, Yew-Min Tzeng

Natl Sci Rev· November 2022

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Application of Multiple Strategies to Improve the Production of the Potential Cancer Drug 4-Acetylantroquinonol B (4-AAQB) by the Rare Fungus Antrodia cinnamomea.
Huan Liu, Hao Xing, Yuhan Jin, Jie Liu, Yew-Min Tzeng

Appl Biochem Biotechnol· June 2022

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Urokinase plasminogen activator induces epithelial-mesenchymal and metastasis of pancreatic cancer through plasmin/MMP14/TGF-β axis, which is inhibited by 4-acetyl-antroquinonol B treatment.
Chung-Ze Wu, Yi Cheng Chu, Shiue-Wei Lai, Ming-Shou Hsieh, Vijesh Kumar Yadav, Yew-Min Tzeng

Phytomedicine· June 2022

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Identification of a Novel Theranostic Signature of Metabolic and Immune-Inflammatory Dysregulation in Myocardial Infarction, and the Potential Therapeutic Properties of Ovatodiolide, a Diterpenoid Derivative.
Alexander T H Wu, Bashir Lawal, Yew-Min Tzeng, Chun-Che Shih, Chun-Ming Shih

Int J Mol Sci· January 2022

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Genotoxicity and 28-day repeated dose oral toxicity study of ovatodiolide in rats.
Jing-Chun Chen, Yan-Zhen Dai, Yew-Min Tzeng, Jiunn-Wang Liao

Toxicol Rep· October 2021

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4-Acetylantroquinonol B induced DNA damage response signaling and apoptosis via suppressing CDK2/CDK4 expression in triple negative breast cancer cells.
Pamungkas Bagus Satriyo, Chih Ming Su, Jiann Ruey Ong, Wen-Chien Huang, Iat-Hang Fong, Yew-Min Tzeng

Toxicol Appl Pharmacol· July 2021

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4-Acetyl-Antroquinonol B Improves the Sensitization of Cetuximab on Both Kras Mutant and Wild Type Colorectal Cancer by Modulating the Expression of Ras/Raf/miR-193a-3p Signaling Axis.
Yi Cheng Chu, Tung-Yao Tsai, Vijesh Kumar Yadav, Li Deng, Chun-Chih Huang, Yew-Min Tzeng

Int J Mol Sci· July 2021

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Ovatodiolide Suppresses Oral Cancer Malignancy by Down-Regulating Exosomal Mir-21/STAT3/β-Catenin Cargo and Preventing Oncogenic Transformation of Normal Gingival Fibroblasts.
Jia-Hong Chen, Alexander T H Wu, Oluwaseun Adebayo Bamodu, Vijesh Kumar Yadav, Tsu-Yi Chao, Yew-Min Tzeng

Cancers (Basel)· December 2019

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Ovatodiolide inhibits the oncogenicity and cancer stem cell-like phenotype of glioblastoma cells, as well as potentiate the anticancer effect of temozolomide.
Yu-Kai Su, Oluwaseun Adebayo Bamodu, Yew-Min Tzeng, Michael Hsiao, Chi-Tai Yeh

Phytomedicine· August 2019

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Ovatodiolide suppresses nasopharyngeal cancer by targeting stem cell-like population, inducing apoptosis, inhibiting EMT and dysregulating JAK/STAT signaling pathway.
Shao-Cheng Liu, Chih-Ming Huang, Oluwaseun Adebayo Bamodu, Chun-Shu Lin, Bing-Lan Liu, Yew-Min Tzeng

Phytomedicine· March 2019

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Antrocin, a bioactive component from Antrodia cinnamomea, suppresses breast carcinogenesis and stemness via downregulation of β-catenin/Notch1/Akt signaling.
Jia-Hong Chen, Alexander T H Wu, David T W Tzeng, Chi-Cheng Huang, Yew-Min Tzeng

Phytomedicine· January 2019

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Downregulation of Cancer Stemness by Novel Diterpenoid Ovatodiolide Inhibits Hepatic Cancer Stem Cell-Like Traits by Repressing Wnt/[Formula: see text]-Catenin Signaling.
Mingche Liu, Oluwaseun Adebayo Bamodu, Kuang-Tai Kuo, Wei-Hwa Lee, Yen-Kuang Lin, Yew-Min Tzeng

Am J Chin Med· October 2018

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Ovatodiolide suppresses yes-associated protein 1-modulated cancer stem cell phenotypes in highly malignant hepatocellular carcinoma and sensitizes cancer cells to chemotherapy in vitro.
Hang-Lung Chang, Hsin-An Chen, Oluwaseun Adebayo Bamodu, Kwai-Fong Lee, Yew-Min Tzeng

Toxicol In Vitro· September 2018

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Destruxin B Suppresses Drug-Resistant Colon Tumorigenesis and Stemness Is Associated with the Upregulation of miR-214 and Downregulation of mTOR/β-Catenin Pathway.
Szu-Yuan Wu, Yan-Jiun Huang, Yew-Min Tzeng, Chi-Ying F Huang, Michael Hsiao

Cancers (Basel)· September 2018

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Investigation of ovatodiolide, a macrocyclic diterpenoid, as a potential inhibitor of oral cancer stem-like cells properties via the inhibition of the JAK2/STAT3/JARID1B signal circuit.
Chun-Shu Lin, Oluwaseun Adebayo Bamodu, Kuang-Tai Kuo, Chih-Ming Huang, Shao-Cheng Liu, Yew-Min Tzeng

Phytomedicine· July 2018

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A comparative proteomic study of secretomes in kaempferitrin-treated CTX TNA2 astrocytic cells.
Wei-Chi Ku, Yi-Ling Chang, Sheng-Fa Wu, Hui-Nung Shih, Yew-Min Tzeng

Phytomedicine· December 2017

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Antcin-H Isolated from Inhibits Renal Cancer Cell Invasion Partly through Inactivation of FAK-ERK-C/EBP-/c-Fos-MMP-7 Pathways.
Kun-Yuan Chiu, Tzu-Hsiu Chen, Chi-Luan Wen, Jin-Mei Lai, Chi-Chih Cheng, Yew-Min Tzeng

Evid Based Complement Alternat Med· November 2017

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