Publications by authors named "Ying Chuan Lin"

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Small molecule regulation of protein conformation by binding in the Flap of HIV protease.
Theresa Tiefenbrunn, Stefano Forli, Michael M Baksh, Max W Chang, Meaghan Happer, Ying-Chuan Lin

ACS Chem Biol· August 2014

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Selection of drug-resistant feline immunodeficiency virus (FIV) encoding FIV/HIV chimeric protease in the presence of HIV-specific protease inhibitors.
Ying-Chuan Lin, Meaghan Happer, John H Elder

J Virol· August 2013

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Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease.
Ying Chuan Lin, Alexander L Perryman, Arthur J Olson, Bruce E Torbett, John H Elder

Acta Crystallogr D Biol Crystallogr· June 2011

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Generation of infectious feline immunodeficiency virus (FIV) encoding FIV/human immunodeficiency virus chimeric protease.
Ying-Chuan Lin, Bruce E Torbett, John H Elder

J Virol· July 2010

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Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV.
John H Elder, Ying-Chuan Lin, Elizabeth Fink, Chris K Grant

Curr HIV Res· January 2010

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A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant.
Michael J Giffin, Holly Heaslet, Ashraf Brik, Ying-Chuan Lin, Gabrielle Cauvi

J Med Chem· October 2008

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Molecular mechanisms of FIV infection.
John H Elder, Magnus Sundstrom, Sohela de Rozieres, Aymeric de Parseval, Chris K Grant, Ying-Chuan Lin

Vet Immunol Immunopathol· May 2008

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Conformational flexibility in the flap domains of ligand-free HIV protease.
Holly Heaslet, Robin Rosenfeld, Mike Giffin, Ying Chuan Lin, Karen Tam

Acta Crystallogr D Biol Crystallogr· August 2007

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Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3.
Holly Heaslet, Ying-Chuan Lin, Karen Tam, Bruce E Torbett, John H Elder

Retrovirology· January 2007

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Rapid discovery and structure-activity profiling of novel inhibitors of human immunodeficiency virus type 1 protease enabled by the copper(I)-catalyzed synthesis of 1,2,3-triazoles and their further functionalization.
Matthew Whiting, Jonathan C Tripp, Ying-Chuan Lin, William Lindstrom, Arthur J Olson

J Med Chem· December 2006

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Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system.
Ying-Chuan Lin, Ashraf Brik, Aymeric de Parseval, Karen Tam, Bruce E Torbett

J Virol· August 2006

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Structural insights into the mechanisms of drug resistance in HIV-1 protease NL4-3.
Holly Heaslet, Victoria Kutilek, Garrett M Morris, Ying-Chuan Lin, John H Elder

J Mol Biol· March 2006

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Epoxide opening in water and screening in situ for rapid discovery of enzyme inhibitors in microtiter plates.
Fu-Sen Liang, Ashraf Brik, Ying-Chuan Lin, John H Elder, Chi-Huey Wong

Bioorg Med Chem· February 2006

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Inhibitors of HIV-1 protease by using in situ click chemistry.
Matthew Whiting, John Muldoon, Ying-Chuan Lin, Steven M Silverman, William Lindstrom

Angew Chem Int Ed Engl· February 2006

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1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors.
Ashraf Brik, Jerry Alexandratos, Ying-Chuan Lin, John H Elder, Arthur J Olson

Chembiochem· July 2005

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Assessment of FIV-C infection of cats as a function of treatment with the protease inhibitor, TL-3.
Sohela de Rozières, Christina H Swan, Dennis A Sheeter, Karen J Clingerman, Ying-Chuan Lin

Retrovirology· November 2004

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Resolution and prevention of feline immunodeficiency virus-induced neurological deficits by treatment with the protease inhibitor TL-3.
Salvador Huitron-Resendiz, Sohela De Rozières, Manuel Sanchez-Alavez, Bernd Bühler, Ying-Chuan Lin

J Virol· May 2004

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Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors.
Ashraf Brik, John Muldoon, Ying-Chuan Lin, John H Elder, David S Goodsell

Chembiochem· November 2003

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Structural basis for distinctions between substrate and inhibitor specificities for feline immunodeficiency virus and human immunodeficiency virus proteases.
Ying-Chuan Lin, Zachary Beck, Garrett M Morris, Arthur J Olson, John H Elder

J Virol· June 2003

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Determination of beam intensity in a single step for IMRT inverse planning.
Keh-Shih Chuang, Tzong-Jer Chen, Shan-Chi Kuo, Meei-Ling Jan, Ing-Ming Hwang, Ying-Chuan Lin

Phys Med Biol· February 2003

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A quick diversity-oriented amide-forming reaction to optimize P-subsite residues of HIV protease inhibitors.
Ashraf Brik, Ying-Chuan Lin, John Elder, Chi-Huey Wong

Chem Biol· August 2002

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