Publications by authors named "Yipei Gu"

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Discovery of Highly Potent, Selective, and Liver-Targeted THR-β Agonists for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis.
Ju Liang, Yipei Gu, Liuyu Hu, Hui Qu, Nana Li

J Med Chem· August 2025

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A novel TGR5 agonist Sauchinone ameliorates IMQ induced murine psoriasis by regulating macrophage polarization.
Hao-Yu Wang, Su-Ling Huang, Jing Ren, Li-Yan Peng, Lin-Rui Chen, Yi-Pei Gu

J Adv Res· April 2025

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A new mechanism of thyroid hormone receptor β agonists ameliorating nonalcoholic steatohepatitis by inhibiting intestinal lipid absorption via remodeling bile acid profiles.
Kai Sun, Nan-Lin Zhu, Su-Ling Huang, Hui Qu, Yi-Pei Gu

Acta Pharmacol Sin· October 2024

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TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis.
Wen-Ji Yang, Fang-Hui Han, Yi-Pei Gu, Hui Qu, Jia Liu

Acta Pharmacol Sin· August 2023

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Discovery of Highly Potent and Selective Thyroid Hormone Receptor β Agonists for the Treatment of Nonalcoholic Steatohepatitis.
Liuyu Hu, Yipei Gu, Ju Liang, Mengmeng Ning, Junli Yang

J Med Chem· March 2023

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Design and exploration of gut-restricted bifunctional molecule with TGR5 agonistic and DPP4 inhibitory effects for treating ulcerative colitis.
Fanghui Han, Mengmeng Ning, Kai Wang, Yipei Gu, Hui Qu

Eur J Med Chem· November 2022

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Discovery of novel ketoxime ether derivatives with potent FXR agonistic activity, oral effectiveness and high liver/blood ratio.
Xuehang Tang, Mengmeng Ning, Yangliang Ye, Yipei Gu, Hongyi Yan

Bioorg Med Chem· August 2021

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Dipeptidyl peptidase 4 inhibitor sitagliptin protected against dextran sulfate sodium-induced experimental colitis by potentiating the action of GLP-2.
Meng-Meng Ning, Wen-Ji Yang, Wen-Bo Guan, Yi-Pei Gu, Ying Feng

Acta Pharmacol Sin· November 2020

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