Publications by authors named "Yongcan Wu"

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Resveratrol attenuates pulmonary fibrosis by inhibiting alveolar epithelial senescence via targeting SASP-related proteins: an integrated bioinformatics-experimental study.
Biao Zuo, Su Yuan, Chen Luo, Xu-Qin Du, Yong-Can Wu

Front Pharmacol· December 2025

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Gan-du-qing attenuates PM-induced Chronic Airway Inflammation via regulating the pulmonary microbiota and metabolic profiles.
Yongcan Wu, Biao Zuo, Xin Zhou, Sijing Zhao, Caixia Pei

Front Med (Lausanne)· September 2025

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Probiotics improve lung function and QOL in participants with exposure to fine particulate matter air pollution: a randomized, double-blind, placebo-controlled clinical trial.
Yongcan Wu, Caixia Pei, Xiaomin Wang, Yilan Wang, Demei Huang

Food Funct· May 2025

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Preconditioning with Ginsenoside Rg3 mitigates cardiac injury induced by high-altitude hypobaric hypoxia exposure in mice by suppressing ferroptosis through inhibition of the RhoA/ROCK signaling pathway.
Junling Liu, Caixia Pei, Nan Jia, Yue Han, Sijing Zhao, Yongcan Wu

J Ethnopharmacol· January 2025

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Eleutheroside B Pretreatment Attenuates Hypobaric Hypoxia-Induced High-Altitude Pulmonary Edema by Regulating Autophagic Flux via the AMPK/mTOR Pathway.
Caixia Pei, Zherui Shen, Yongcan Wu, Sijing Zhao, Yilan Wang

Phytother Res· December 2024

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Notoginsenoside R1 treatment facilitated Nrf2 nuclear translocation to suppress ferroptosis via Keap1/Nrf2 signaling pathway to alleviated high-altitude myocardial injury.
Yilan Wang, Yongjun Yin, Ying Liu, Caixia Pei, Zherui Shen, Yongcan Wu

Biomed Pharmacother· June 2024

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Notoginsenoside R1 protects against hypobaric hypoxia-induced high-altitude pulmonary edema by inhibiting apoptosis via ERK1/2-P90rsk-BAD ignaling pathway.
Caixia Pei, Nan Jia, Yilan Wang, Sijing Zhao, Zherui Shen, Yongcan Wu

Eur J Pharmacol· November 2023

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Protective effects of Eleutheroside E against high-altitude pulmonary edema by inhibiting NLRP3 inflammasome-mediated pyroptosis.
Zherui Shen, Demei Huang, Nan Jia, Sijing Zhao, Caixia Pei, Yongcan Wu

Biomed Pharmacother· November 2023

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Eleutheroside E from pre-treatment of Acanthopanax senticosus (Rupr.etMaxim.) Harms ameliorates high-altitude-induced heart injury by regulating NLRP3 inflammasome-mediated pyroptosis via NLRP3/caspase-1 pathway.
Nan Jia, Zherui Shen, Sijing Zhao, Yilan Wang, Caixia Pei, Yongcan Wu

Int Immunopharmacol· August 2023

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Salidroside pretreatment alleviates PM caused lung injury via inhibition of apoptosis and pyroptosis through regulating NLRP3 Inflammasome.
Shihua Shi, Demei Huang, Yongcan Wu, Caixia Pei, Yilan Wang

Food Chem Toxicol· July 2023

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Rosavidin protects against PM2.5-induced lung toxicity via inhibition of NLRP3 inflammasome-mediated pyroptosis by activating the PI3K/AKT pathway.
Demei Huang, Nan Jia, Caixia Pei, Zherui Shen, Sijing Zhao, Yongcan Wu

Biochem Pharmacol· July 2023

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Sipeimine attenuates PM2.5-induced lung toxicity via suppression of NLRP3 inflammasome-mediated pyroptosis through activation of the PI3K/AKT pathway.
Demei Huang, Zherui Shen, Sijing Zhao, Caixia Pei, Nan Jia, Yongcan Wu

Chem Biol Interact· May 2023

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Pretreatment with rosavin attenuates PM2.5-induced lung injury in rats through antiferroptosis via PI3K/Akt/Nrf2 signaling pathway.
Yilan Wang, Sijing Zhao, Nan Jia, Zherui Shen, Demei Huang, Yongcan Wu

Phytother Res· January 2023

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Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling.
Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Yongcan Wu

Biomed Pharmacother· December 2022

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Astragaloside IV regulates the ferroptosis signaling pathway via the Nrf2/SLC7A11/GPX4 axis to inhibit PM2.5-mediated lung injury in mice.
Xiaoming Wang, Yilan Wang, Demei Huang, Shihua Shi, Caixia Pei, Yongcan Wu

Int Immunopharmacol· November 2022

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Probiotics ameliorates pulmonary inflammation via modulating gut microbiota and rectifying Th17/Treg imbalance in a rat model of PM2.5 induced lung injury.
Yongcan Wu, Caixia Pei, Xiaomin Wang, Yilan Wang, Demei Huang

Ecotoxicol Environ Saf· October 2022

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Efficacy and Safety of Shenfu Injection for Severe Pneumonia in the Elderly: A Systematic Review and Meta-Analysis Based on Western and Eastern Medicine.
Shihua Shi, Fei Wang, Bonan Chen, Jie Pan, Dan Luo, Yongcan Wu

Front Pharmacol· August 2022

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Sipeimine ameliorates PM2.5-induced lung injury by inhibiting ferroptosis via the PI3K/Akt/Nrf2 pathway: A network pharmacology approach.
Yilan Wang, Zherui Shen, Sijing Zhao, Demei Huang, Xiaomin Wang, Yongcan Wu

Ecotoxicol Environ Saf· July 2022

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Astragaloside IV alleviates PM2.5-caused lung toxicity by inhibiting inflammasome-mediated pyroptosis via NLRP3/caspase-1 axis inhibition in mice.
Demei Huang, Shihua Shi, Yilan Wang, Xiaomin Wang, Zherui Shen, Yongcan Wu

Biomed Pharmacother· June 2022

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Epimedium for Osteoporosis Based on Western and Eastern Medicine: An Updated Systematic Review and Meta-Analysis.
Shihua Shi, Fei Wang, Yong Huang, Bonan Chen, Caixia Pei, Yongcan Wu

Front Pharmacol· March 2022

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Astragaloside IV pre-treatment attenuates PM2.5-induced lung injury in rats: Impact on autophagy, apoptosis and inflammation.
Zhenxing Wang, Yongcan Wu, Caixia Pei, Mingjie Wang, Xiaomin Wang

Phytomedicine· February 2022

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Effect of omega-3 fatty acids on TH1/TH2 polarization in individuals with high exposure to particulate matter ≤ 2.5 μm (PM2.5): a randomized, double-blind, placebo-controlled clinical study.
Xiaomin Wang, Shuiqin Li, Yongcan Wu, Demei Huang, Caixia Pei

Trials· February 2022

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Oral Chinese Herbal Medicine on Immune Responses During Coronavirus Disease 2019: A Systematic Review and Meta-Analysis.
Shihua Shi, Fei Wang, Huan Yao, Shuo Kou, Weihao Li, Yongcan Wu

Front Med (Lausanne)· January 2022

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Astragaloside IV Protects from PM2.5-Induced Lung Injury by Regulating Autophagy via Inhibition of PI3K/Akt/mTOR Signaling in vivo and in vitro.
Caixia Pei, Fei Wang, Demei Huang, Shihua Shi, Xiaomin Wang, Yongcan Wu

J Inflamm Res· September 2021

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Suppression of NLRP3 inflammasome by Platycodin D via the TLR4/MyD88/NF-κB pathway contributes to attenuation of lipopolysaccharide induced acute lung injury in rats.
Yongcan Wu, Demei Huang, Xiaomin Wang, Caixia Pei, Wei Xiao

Int Immunopharmacol· July 2021

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