Publications by authors named "Yorgo Modis"

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Protocol for the expression, purification, and biochemical characterization of the innate immune sensor MDA5.
Joe D Joiner, Alba Herrero Del Valle, Rahul Singh, Yorgo Modis

STAR Protoc· November 2025

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Molecular basis of autoimmune disease protection by MDA5 variants.
Rahul Singh, Joe D Joiner, Alba Herrero Del Valle, Marleen Zwaagstra, Ida Jobe, Yorgo Modis

Cell Rep· June 2025

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MDA5 variants trade antiviral activity for protection from autoimmune disease.
Chris Wallace, Rahul Singh, Yorgo Modis

BMC Med Genomics· June 2025

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Structure and Methyl-lysine Binding Selectivity of the HUSH Complex Subunit MPP8.
Nikos Nikolopoulos, Shun-Ichiro Oda, Daniil M Prigozhin, Yorgo Modis

J Mol Biol· January 2025

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Contrasting functions of ATP hydrolysis by MDA5 and LGP2 in viral RNA sensing.
Rahul Singh, Yuan Wu, Alba Herrero Del Valle, Kendra E Leigh, Sai Mong, Yorgo Modis

J Biol Chem· March 2024

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The vaccinia chondroitin sulfate binding protein drives host membrane curvature to facilitate fusion.
Laura Pokorny, Jemima J Burden, David Albrecht, Rebecca Bamford, Kendra E Leigh, Yorgo Modis

EMBO Rep· March 2024

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Crystal structure and biochemical activity of the macrodomain from rubella virus p150.
Guido A Stoll, Nikos Nikolopoulos, Haoming Zhai, Liao Zhang, Christopher H Douse, Yorgo Modis

J Virol· February 2024

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Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization.
Yangci Liu, Haoming Zhai, Helen Alemayehu, Jérôme Boulanger, Lee J Hopkins, Yorgo Modis

Nat Commun· November 2023

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Structure and functional mapping of the KRAB-KAP1 repressor complex.
Guido A Stoll, Ninoslav Pandiloski, Christopher H Douse, Yorgo Modis

EMBO J· December 2022

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Author Correction: SARS-CoV-2 evolution during treatment of chronic infection.
Steven A Kemp, Dami A Collier, Rawlings P Datir, Isabella A T M Ferreira, Salma Gayed, Yorgo Modis

Nature· August 2022

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A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus.
Monique Merchant, Carlos P Mata, Yangci Liu, Haoming Zhai, Anna V Protasio, Yorgo Modis

Sci Adv· May 2022

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Imaging and visualizing SARS-CoV-2 in a new era for structural biology.
Kendra E Leigh, Yorgo Modis

Interface Focus· December 2021

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MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Qin Yu, Alba Herrero Del Valle, Rahul Singh, Yorgo Modis

Nat Commun· November 2021

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SARS-CoV-2 evolution during treatment of chronic infection.
Steven A Kemp, Dami A Collier, Rawlings P Datir, Isabella A T M Ferreira, Salma Gayed, Yorgo Modis

Nature· April 2021

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Equilibrium Binding Model for CpG DNA-Dependent Dimerization of Toll-like Receptor 9 Ectodomain.
Stephanie Reikine, Stephen H McLaughlin, Yorgo Modis

Biochemistry· November 2020

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Periphilin self-association underpins epigenetic silencing by the HUSH complex.
Daniil M Prigozhin, Christopher H Douse, Laura E Farleigh, Anna Albecka, Iva A Tchasovnikarova, Yorgo Modis

Nucleic Acids Res· October 2020

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TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.
Christopher H Douse, Iva A Tchasovnikarova, Richard T Timms, Anna V Protasio, Marta Seczynska, Yorgo Modis

Nat Commun· October 2020

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FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle.
M Zaeem Cader, Rodrigo Pereira de Almeida Rodrigues, James A West, Gavin W Sewell, Muhammad N Md-Ibrahim, Yorgo Modis

Cell· February 2020

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FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle.
M Zaeem Cader, Rodrigo Pereira de Almeida Rodrigues, James A West, Gavin W Sewell, Muhammad N Md-Ibrahim, Yorgo Modis

Cell· January 2020

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Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing.
Guido A Stoll, Shun-Ichiro Oda, Zheng-Shan Chong, Minmin Yu, Stephen H McLaughlin, Yorgo Modis

Proc Natl Acad Sci U S A· July 2019

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Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.
Zinan Zhang, Florian Gothe, Perrine Pennamen, John R James, David McDonald, Yorgo Modis

J Exp Med· June 2019

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MAVS polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling.
Ming-Shih Hwang, Jérôme Boulanger, Jonathan D Howe, Anna Albecka, Mathias Pasche, Yorgo Modis

FEBS J· April 2019

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Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Qin Yu, Kun Qu, Yorgo Modis

Mol Cell· December 2018

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A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway.
Christopher C T Sng, Sorcha O'Byrne, Daniil M Prigozhin, Matthias R Bauer, Jennifer C Harvey, Yorgo Modis

J Allergy Clin Immunol· July 2018

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Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.
Christopher H Douse, Stuart Bloor, Yangci Liu, Maria Shamin, Iva A Tchasovnikarova, Yorgo Modis

Nat Commun· February 2018

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