Publications by authors named "Yoshiaki Isobe"

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Discovery of N-(6-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridazin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)methanesulfonamide as a brain-permeable and metabolically stable kynurenine monooxygenase inhibitor.
Katsunori Tsuboi, Hidenori Kimura, Yoshie Nakatsuji, Momoe Kassai, Yoko Deai, Yoshiaki Isobe

Bioorg Med Chem Lett· July 2021

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Identification of 2-fluoro-8-methyl-11-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepine with clozapine-like mixed activities at muscarinic acetylcholine, dopamine, and serotonin receptors.
Hitoshi Watanabe, Kyoji Ishida, Masanori Yamamoto, Tomokazu Nakako, Masakuni Horiguchi, Yoshiaki Isobe

Bioorg Med Chem Lett· May 2021

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N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors.
Hidenori Kimura, Hitoshi Suda, Momoe Kassai, Mika Endo, Yoko Deai, Yoshiaki Isobe

Bioorg Med Chem Lett· February 2021

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Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepines with clozapine-like receptor occupancy at dopamine D/D receptor.
Hitoshi Watanabe, Kyoji Ishida, Masanori Yamamoto, Masakuni Horiguchi, Yoshiaki Isobe

Bioorg Med Chem Lett· November 2020

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Structural analysis reveals TLR7 dynamics underlying antagonism.
Shingo Tojo, Zhikuan Zhang, Hiroyuki Matsui, Masahiro Tahara, Mitsunori Ikeguchi, Yoshiaki Isobe

Nat Commun· October 2020

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Synthesis and biological evaluation of novel orally available 1-phenyl-6-aminouracils containing dimethyldihydrobenzofuranol structure for the treatment of allergic skin diseases.
Masanori Tobe, Katsunori Tsuboi, Futoshi Hasegawa, Norio Fujiwara, Yoshifumi Inoue, Masakazu Isobe, Yoshiaki Isobe

Bioorg Med Chem Lett· February 2016

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Dihydropyrrolo[2,3-d]pyrimidines: Selective Toll-Like Receptor 9 Antagonists from Scaffold Morphing Efforts.
Manabu Watanabe, Mai Kasai, Hideyuki Tomizawa, Masamitsu Aoki, Kazuo Eiho, Yoshiaki Isobe

ACS Med Chem Lett· November 2014

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Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors.
Shingo Tojo, Tetsuya Kohno, Tomoyuki Tanaka, Seiji Kamioka, Yosuke Ota, Yoshiaki Isobe

ACS Med Chem Lett· October 2014

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Synthesis of novel benzo-fused heteroaryl derivatives as Ca²⁺/calmodulin-dependent protein kinase II inhibitors.
Masafumi Komiya, Shigehiro Asano, Nobuyuki Koike, Erina Koga, Junetsu Igarashi, Yoshiaki Isobe

Chem Pharm Bull (Tokyo)· May 2014

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Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility.
Tomoaki Nakamura, Hiroki Wada, Hirotaka Kurebayashi, Tom McInally, Roger Bonnert, Yoshiaki Isobe

Bioorg Med Chem Lett· February 2013

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Synthesis and structure based optimization of 2-(4-phenoxybenzoyl)-5-hydroxyindole as a novel CaMKII inhibitor.
Masafumi Komiya, Shigehiro Asano, Nobuyuki Koike, Erina Koga, Junetsu Igarashi, Yoshiaki Isobe

Bioorg Med Chem· December 2012

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Circadian rhythm of metabolic oscillation in suprachiasmatic nucleus depends on the mitochondrial oxidation state, reflected by cytochrome C oxidase and lactate dehydrogenase.
Yoshiaki Isobe, Hideki Hida, Hitoo Nishino

J Neurosci Res· June 2011

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Circadian rhythm of enolase in suprachiasmatic nucleus depends on mitochondrial function.
Yoshiaki Isobe, Hideki Hida, Hitoo Nishino

J Neurosci Res· June 2011

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Synthesis and structure-activity relationship of tricyclic carboxylic acids as novel anti-histamines.
Katsumi Kubota, Hirotaka Kurebayashi, Hirotaka Miyachi, Masanori Tobe, Masako Onishi, Yoshiaki Isobe

Bioorg Med Chem· May 2011

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Structure and activity relationship of 2-(substituted benzoyl)-hydroxyindoles as novel CaMKII inhibitors.
Masafumi Komiya, Shigehiro Asano, Nobuyuki Koike, Erina Koga, Junetsu Igarashi, Yoshiaki Isobe

Bioorg Med Chem Lett· March 2011

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5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors.
Shigehiro Asano, Masafumi Komiya, Nobuyuki Koike, Erina Koga, Shogo Nakatani, Yoshiaki Isobe

Bioorg Med Chem Lett· November 2010

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Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept.
Ayumu Kurimoto, Kazuki Hashimoto, Tomoaki Nakamura, Kei Norimura, Haruhisa Ogita, Yoshiaki Isobe

J Med Chem· April 2010

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Diethylnitrosamine-induced hepatic lesions are greater in rats maintained under a light-dark cycle than under constant light, related to the locomotor activity rhythm.
Yoshiaki Isobe, Katsumi Fukamachi, Hideki Hida, Hiroyuki Tsuda, Hitoo Nishino

Asian Pac J Cancer Prev· May 2009

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Synthesis and structure-activity relationships of phenothiazine carboxylic acids having pyrimidine-dione as novel histamine H(1) antagonists.
Katsumi Kubota, Hirotaka Kurebayashi, Hirotaka Miyachi, Masanori Tobe, Masako Onishi, Yoshiaki Isobe

Bioorg Med Chem Lett· May 2009

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Enhanced neurogenesis from neural progenitor cells with G1/S-phase cell cycle arrest is mediated by transforming growth factor beta1.
Sachiyo Misumi, Tae-Sun Kim, Cha-Gyun Jung, Tadashi Masuda, Susumu Urakawa, Yoshiaki Isobe

Eur J Neurosci· September 2008

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Increase in dopaminergic neurons from mouse embryonic stem cell-derived neural progenitor/stem cells is mediated by hypoxia inducible factor-1alpha.
Tae-Sun Kim, Sachiyo Misumi, Cha-Gyun Jung, Tadashi Masuda, Yoshiaki Isobe

J Neurosci Res· August 2008

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Increase in neurogenesis and neuroblast migration after a small intracerebral hemorrhage in rats.
Tadashi Masuda, Yoshiaki Isobe, Noritaka Aihara, Fujiya Furuyama, Sachiyo Misumi

Neurosci Lett· September 2007

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Synthesis and biological evaluation of novel 9-substituted-8-hydroxyadenine derivatives as potent interferon inducers.
Yoshiaki Isobe, Ayumu Kurimoto, Masanori Tobe, Kazuki Hashimoto, Tomoaki Nakamura

J Med Chem· March 2006

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Dexamethasone induces different wheel running activity than corticosterone through vasopressin release from the suprachiasmatic nucleus.
Yoshiaki Isobe, Takako Torii, Takatsune Kawaguchi, Hitoo Nishino

Brain Res· December 2004

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Signal transmission from the suprachiasmatic nucleus to the pineal gland via the paraventricular nucleus: analysed from arg-vasopressin peptide, rPer2 mRNA and AVP mRNA changes and pineal AA-NAT mRNA after the melatonin injection during light and dark periods.
Yoshiaki Isobe, Hitoo Nishino

Brain Res· July 2004

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