Publications by authors named "Yoshiko Awazu"

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A novel inhibitor of c-Met and VEGF receptor tyrosine kinases with a broad spectrum of in vivo antitumor activities.
Yoshiko Awazu, Kazuhide Nakamura, Akio Mizutani, Yuichi Kakoi, Hidehisa Iwata

Mol Cancer Ther· June 2013

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Anti-angiogenic and anti-tumor effects of TAK-593, a potent and selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinase.
Yoshiko Awazu, Akio Mizutani, Yoshinori Nagase, Shuntarou Tsuchiya, Kazuhide Nakamura

Cancer Sci· April 2013

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Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor.
Naoki Miyamoto, Nozomu Sakai, Takaharu Hirayama, Kazuhiro Miwa, Yuya Oguro, Yoshiko Awazu

Bioorg Med Chem· April 2013

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Structure-based discovery of cellular-active allosteric inhibitors of FAK.
Naoki Tomita, Yoko Hayashi, Shinkichi Suzuki, Yoshimasa Oomori, Yoshio Aramaki, Yoshiko Awazu

Bioorg Med Chem Lett· March 2013

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A novel pyrrolo[3, 2-d]pyrimidine derivative, as a vascular endothelial growth factor receptor and platelet-derived growth factor receptor tyrosine kinase inhibitor, shows potent antitumor activity by suppression of tumor angiogenesis.
Yoshiko Awazu, Akio Mizutani, Yoshinori Nagase, Hidehisa Iwata, Yuya Oguro

Cancer Sci· May 2012

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Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: novel VEGFR2 kinase inhibitors binding to inactive kinase conformation.
Yuya Oguro, Naoki Miyamoto, Kengo Okada, Terufumi Takagi, Hidehisa Iwata, Yoshiko Awazu

Bioorg Med Chem· October 2010

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N-phenyl-N'-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as novel inhibitors of VEGFR and FGFR kinases.
Yuya Oguro, Naoki Miyamoto, Terufumi Takagi, Kengo Okada, Yoshiko Awazu

Bioorg Med Chem· October 2010

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