Publications by authors named "Yu Hirota"

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Biomarker-related phospho-tau217 appears in synapses around Aβ plaques prior to tau tangle in cerebral cortex of preclinical Alzheimer's disease.
Yu Hirota, Yasufumi Sakakibara, Maho Morishima, Terunori Sano, Manato Hara

Cell Rep· September 2025

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Decreased plasma nicotinamide and altered NAD metabolism in glial cells surrounding Aβ plaques in a mouse model of Alzheimer's disease.
Michiko Sekiya, Yasufumi Sakakibara, Yu Hirota, Naoki Ito, Sachie Chikamatsu

Neurobiol Dis· November 2024

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Alzheimer's Disease-Related Phospho-Tau181 Signals Are Localized to Demyelinated Axons of Parvalbumin-Positive GABAergic Interneurons in an App Knock-In Mouse Model of Amyloid-β Pathology.
Yu Hirota, Yasufumi Sakakibara, Kimi Takei, Risa Nishijima, Michiko Sekiya

J Alzheimers Dis· June 2023

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is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration.
Yasufumi Sakakibara, Risa Yamashiro, Sachie Chikamatsu, Yu Hirota, Yoko Tsubokawa

iScience· February 2023

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Distinct brain pathologies associated with Alzheimer's disease biomarker-related phospho-tau 181 and phospho-tau 217 in knock-in mouse models of amyloid-β amyloidosis.
Yu Hirota, Yasufumi Sakakibara, Kyoko Ibaraki, Kimi Takei, Koichi M Iijima

Brain Commun· November 2022

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Intracerebral Delivery of an OTR Antagonist and Subsequent Behavioral Testing in Prairie Voles.
Yu Hirota, Chisato Otsuki, Erika Kamura, Shinichi Mitsui

Methods Mol Biol· January 2022

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Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis.
Yasufumi Sakakibara, Yu Hirota, Kyoko Ibaraki, Kimi Takei, Sachie Chikamatsu

J Alzheimers Dis· November 2021

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Oxytocin receptor antagonist reverses the blunting effect of pair bonding on fear learning in monogamous prairie voles.
Yu Hirota, Aki Arai, Larry J Young, Yoji Osako, Kazunari Yuri

Horm Behav· April 2020

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A single prolonged stress paradigm produces enduring impairments in social bonding in monogamous prairie voles.
Aki Arai, Yu Hirota, Naoki Miyase, Shiori Miyata, Larry J Young

Behav Brain Res· December 2016

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