Publications by authors named "Yu Togashi"

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Enhancing clinical reasoning skills in medical students through team-based learning: a mixed-methods study.
Kosuke Ishizuka, Kiyoshi Shikino, Naoko Takada, Yohei Sakai, Yasushi Ototake, Yu Togashi

BMC Med Educ· February 2025

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The matricellular protein Fibulin-5 regulates β-cell proliferation in an autocrine/paracrine manner.
Tomoko Okuyama, Takahiro Tsuno, Ryota Inoue, Setsuko Fukushima, Mayu Kyohara, Yu Togashi

iScience· February 2025

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Protective Effects of Imeglimin and Metformin Combination Therapy on β-Cells in db/db Male Mice.
Kuniyuki Nishiyama, Masato Ono, Takahiro Tsuno, Ryota Inoue, Ayako Fukunaka, Yu Togashi

Endocrinology· June 2023

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Protective effects of S100A8 on sepsis mortality: Links to sepsis risk in obesity and diabetes.
Daisuke Miyashita, Ryota Inoue, Takahiro Tsuno, Tomoko Okuyama, Mayu Kyohara, Yu Togashi

iScience· December 2022

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Abdominal aortic calcification is associated with Fibrosis-4 index and low body mass index in type 2 diabetes patients: A retrospective cross-sectional study.
Yu Togashi, Daisuke Miyashita, Takahiro Tsuno, Ryota Inoue, Tomoko Okuyama

J Diabetes Investig· November 2022

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Association between circulating SerpinB1 levels and insulin sensitivity in Japanese with type 2 diabetes: A single-center, cross-sectional, observational study.
Mayu Kyohara, Daisuke Miyashita, Ryota Inoue, Kuniyuki Nishiyama, Takahiro Tsuno, Yu Togashi

PLoS One· November 2022

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E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance.
Jun Shirakawa, Yu Togashi, Giorgio Basile, Tomoko Okuyama, Ryota Inoue

Cell Rep· October 2022

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Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca release from the ER.
Ryota Inoue, Takahiro Tsuno, Yu Togashi, Tomoko Okuyama, Aoi Sato

iScience· July 2022

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Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway.
Jinghe Li, Ryota Inoue, Yu Togashi, Tomoko Okuyama, Aoi Satoh

Diabetes· March 2022

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Effects of Canagliflozin on Hepatic Steatosis, Visceral Fat and Skeletal Muscle among Patients with Type 2 Diabetes and Non-alcoholic Fatty Liver Disease.
Noriko Nishimiya, Kazuki Tajima, Kento Imajo, Akiko Kameda, Eiko Yoshida, Yu Togashi

Intern Med· November 2021

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Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study.
Sakiko Terui, Ryoichi Akamatsu, Masanori Arai, Ryota Inoue, Tomoko Okuyama, Yu Togashi

Diabetes Ther· November 2021

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Asymptomatic meningitis diagnosed by positron emission tomography in a patient with syndrome of inappropriate antidiuretic hormone secretion: a case report.
Masanori Hasebe, Jun Shirakawa, Daisuke Miyashita, Rieko Kunishita, Mayu Kyohara, Yu Togashi

J Med Case Rep· July 2021

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Autosomal dominant diabetes associated with a novel ZYG11A mutation resulting in cell cycle arrest in beta-cells.
Chutima Charoensuk, Prapaporn Jungtrakoon Thamtarana, Chutima Chanprasert, Watip Tangjittipokin, Jun Shirakawa, Yu Togashi

Mol Cell Endocrinol· February 2021

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Association of the plasma xanthine oxidoreductase activity with the metabolic parameters and vascular complications in patients with type 2 diabetes.
Tomoko Okuyama, Jun Shirakawa, Takashi Nakamura, Takayo Murase, Daisuke Miyashita, Yu Togashi

Sci Rep· February 2021

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Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor.
Tomoko Okuyama, Jun Shirakawa, Kazuki Tajima, Yoko Ino, Heidrun Vethe, Yu Togashi

Int J Mol Sci· October 2020

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Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects.
Mayu Kyohara, Jun Shirakawa, Tomoko Okuyama, Yu Togashi, Ryota Inoue

Diabetol Metab Syndr· September 2020

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Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway.
Jun Shirakawa, Kazuki Tajima, Tomoko Okuyama, Mayu Kyohara, Yu Togashi

Diabetologia· March 2020

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Influence of Timing of Insulin Initiation on Long-term Glycemic Control in Japanese Patients with Type 2 Diabetes: A Retrospective Cohort Study.
Takashi Miyazaki, Jun Shirakawa, Jo Nagakura, Makoto Shibuya, Mayu Kyohara, Yu Togashi

Intern Med· December 2019

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Signaling between pancreatic β cells and macrophages via S100 calcium-binding protein A8 exacerbates β-cell apoptosis and islet inflammation.
Hideaki Inoue, Jun Shirakawa, Yu Togashi, Kazuki Tajima, Tomoko Okuyama

J Biol Chem· April 2018

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Serum Quantitative Proteomic Analysis Reveals Soluble EGFR To Be a Marker of Insulin Resistance in Male Mice and Humans.
Mayu Kyohara, Jun Shirakawa, Tomoko Okuyama, Ayuko Kimura, Yu Togashi

Endocrinology· December 2017

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Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet.
Kazuki Tajima, Jun Shirakawa, Tomoko Okuyama, Mayu Kyohara, Shunsuke Yamazaki, Yu Togashi

Am J Physiol Endocrinol Metab· September 2017

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Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906.
Kazuki Tajima, Jun Shirakawa, Yu Togashi, Shunsuke Yamazaki, Tomoko Okuyama

Sci Rep· June 2017

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Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.
Tomoko Okuyama, Jun Shirakawa, Hiromi Yanagisawa, Mayu Kyohara, Shunsuke Yamazaki, Yu Togashi

Sci Rep· May 2017

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Evaluation of the appropriateness of using glucometers for measuring the blood glucose levels in mice.
Yu Togashi, Jun Shirakawa, Tomoko Okuyama, Shunsuke Yamazaki, Mayu Kyohara

Sci Rep· May 2016

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DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid.
Jun Shirakawa, Tomoko Okuyama, Mayu Kyohara, Eiko Yoshida, Yu Togashi

Diabetol Metab Syndr· March 2016

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