Publications by authors named "Yuichi Hashimoto"

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Phthalimide: a potential warhead for switchable and bioorthogonal conjugation.
Kosuke Chiba, Takumi Yoshida, Kana Okada, Minoru Ishikawa, Yuichi Hashimoto

Chem Commun (Camb)· August 2025

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Photo-Enhanced Aqueous Solubilization of Azobenzene-Incorporated Lipids.
Shusuke Tomoshige, Yushi Kawasaki, Junki Morimoto, Naohiro Sato, Yuichi Hashimoto

Chem Pharm Bull (Tokyo)· June 2025

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Development of subtype-selective estrogen receptor modulators using the bis(4-hydroxyphenyl)silanol core as a stable isostere of bis(4-hydroxyphenyl)methanol.
Yuichiro Matsumoto, Yuichi Hashimoto, Shinya Fujii

RSC Adv· September 2023

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Design, synthesis and structure-activity relationship of 4-(1,1,1,3,3,3-hexafluoro-2-hydroxyisoprop-2-yl)phenylsilane derivatives as liver X receptor agonists.
Nao Namba, Tomomi Noguchi-Yachide, Yuichiro Matsumoto, Yuichi Hashimoto, Shinya Fujii

Bioorg Med Chem· July 2022

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Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties.
Keigo Hirai, Hiroko Yamashita, Shusuke Tomoshige, Yugo Mishima, Tatsuya Niwa, Yuichi Hashimoto

ACS Med Chem Lett· March 2022

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CLSPCOL rescues Alzheimer's disease mouse models.
Shinya Kusakari, Mikiro Nawa, Yuichi Hashimoto, Masaaki Matsuoka

Transl Neurosci· January 2022

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Improvement in aqueous solubility of achiral symmetric cyclofenil by modification to a chiral asymmetric analog.
Junki Morimoto, Kazunori Miyamoto, Yuki Ichikawa, Masanobu Uchiyama, Makoto Makishima, Yuichi Hashimoto

Sci Rep· June 2021

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[Development of Biological Response Modifiers Based on Unique Medicinal Chemical Strategy].
Yuichi Hashimoto

Yakugaku Zasshi· February 2021

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Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs.
Ryuta Shioi, Fumika Karaki, Hiromasa Yoshioka, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto

PLoS One· January 2021

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-Non-flat substituents: a novel molecular design to improve aqueous solubility in small molecule drug discovery.
Yuki Ichikawa, Michiaki Hiramatsu, Yusuke Mita, Makoto Makishima, Yotaro Matsumoto, Yuichi Hashimoto

Org Biomol Chem· January 2021

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Restoration of the reduced CLSP activity alleviates memory impairment in Alzheimer disease.
Yuichi Hashimoto, Shinya Kusakari, Mikiro Nawa, Koichi Okamoto, Yuka Toyama

Transl Psychiatry· January 2021

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Bisphosphonate esters interact with HMG-CoA reductase membrane domain to induce its degradation.
Yosuke Toyota, Hiromasa Yoshioka, Ikuya Sagimori, Yuichi Hashimoto, Kenji Ohgane

Bioorg Med Chem· July 2020

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A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate.
Hiromasa Yoshioka, Hudson W Coates, Ngee Kiat Chua, Yuichi Hashimoto, Andrew J Brown

Proc Natl Acad Sci U S A· March 2020

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Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols.
Ikuya Sagimori, Hiromasa Yoshioka, Yuichi Hashimoto, Kenji Ohgane

Bioorg Med Chem· February 2020

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Phosphine boranes as less hydrophobic building blocks than alkanes and silanes: Structure-property relationship and estrogen-receptor-modulating potency of 4-phosphinophenol derivatives.
Hiroki Saito, Yuichiro Matsumoto, Yuichi Hashimoto, Shinya Fujii

Bioorg Med Chem· February 2020

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Application of protein knockdown strategy targeting β-sheet structure to multiple disease-associated polyglutamine proteins.
Hiroko Yamashita, Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto

Bioorg Med Chem· January 2020

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Multiplexing fluorogenic esterase-based viability assay with luciferase assays.
Kenji Ohgane, Hiromasa Yoshioka, Yuichi Hashimoto

MethodsX· September 2019

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Design, Synthesis and Biological Evaluation of Novel Nonsteroidal Progesterone Receptor Antagonists Based on Phenylamino-1,3,5-triazine Scaffold.
Kazuma Kaitoh, Aki Nakatsu, Shuichi Mori, Hiroyuki Kagechika, Yuichi Hashimoto

Chem Pharm Bull (Tokyo)· June 2019

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Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton.
Shun Nanjyo, Kenji Ohgane, Hiromasa Yoshioka, Makoto Makishima, Yuichi Hashimoto

Bioorg Med Chem· May 2019

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Development of novel silanol-based human pregnane X receptor (PXR) agonists with improved receptor selectivity.
Hirozumi Toyama, Hitoshi Shirakawa, Michio Komai, Yuichi Hashimoto, Shinya Fujii

Bioorg Med Chem· August 2018

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Efficient Lead Finding, Activity Enhancement and Preliminary Selectivity Control of Nuclear Receptor Ligands Bearing a Phenanthridinone Skeleton.
Yuko Nishiyama, Shinya Fujii, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa

Int J Mol Sci· July 2018

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Novel Nonsteroidal Progesterone Receptor (PR) Antagonists with a Phenanthridinone Skeleton.
Yuko Nishiyama, Shuichi Mori, Makoto Makishima, Shinya Fujii, Hiroyuki Kagechika, Yuichi Hashimoto

ACS Med Chem Lett· July 2018

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Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole derivative.
Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa

Bioorg Med Chem Lett· February 2018

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Structural development of tetrachlorophthalimides as liver X receptor β (LXRβ)-selective agonists with improved aqueous solubility.
Sayaka Nomura, Kaori Endo-Umeda, Shinya Fujii, Makoto Makishima, Yuichi Hashimoto

Bioorg Med Chem Lett· February 2018

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Affinity Labeling with 4-Azidophthalimide (AzPI): Relation between Labeling Rate and Fluorescence Intensity.
Kosuke Chiba, Yuichi Hashimoto, Takao Yamaguchi

Chem Pharm Bull (Tokyo)· October 2017

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