Publications by authors named "Yuichiro Higuchi"

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In Vitro Assessment of Drug-Induced Liver Injury Using Three-Dimensional Cultured HepaSH Cells Derived From Chimeric Mouse Model With Humanized Liver.
Xingming Liu, Yuichiro Higuchi, Yuta Sakamoto, Shota Yanagida, Shotaro Uehara

J Appl Toxicol· December 2025

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Derivation of embryonic stem cells from cloned blastocysts using improved somatic cell nuclear transfer in common marmosets.
Shogo Matoba, Yoko Kurotaki, Satoshi Funaya, Yuko Yamada, Narumi Ogonuki, Yuichiro Higuchi

Stem Cell Reports· December 2025

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Netrin-1 inhibits the attachment and internalization of Hepatitis B virus for hepatocyte infection.
Ying Wang, Kazuhisa Murai, Atsuya Ishida, Narumi Kawasaki, Kazuyuki Kuroki, Yuichiro Higuchi

PLoS Pathog· December 2025

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Alcohol dehydrogenase 4 and aldo-keto reductase 1A1 catalyze the oxidation of 4-hydroxytolbutamide, a metabolite of tolbutamide, in the human liver.
Kazuya Shimomura, Rei Sato, Miyu Watanabe, Yuichiro Higuchi, Shotaro Uehara

Drug Metab Dispos· November 2025

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Prediction of human hepatic clearance with HepaSH monolayers for low-turnover compounds.
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki, Hiroshi Suemizu

Drug Metab Dispos· November 2025

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Chromatin remodeler BRD9 represses transcription of PPARα target genes, including CPT1A to suppress lipid metabolism.
Itsuki Yokoseki, Masataka Nakano, Kiamu Kurosawa, Yuichiro Higuchi, Shotaro Uehara

J Lipid Res· September 2025

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Human aldo-keto reductase (AKR) 1C1 and 1C2 act as coactivators of pregnane X receptor, a master regulator of drug-metabolizing and gluconeogenesis enzymes.
Rei Mitamura, Seiya Takemoto, Yuka Aoyama, Koki Morita, Yuichiro Higuchi

Drug Metab Pharmacokinet· June 2025

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Investigation of pilocarpine oxidative and hydrolytic metabolism in chimeric mice with humanized liver.
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki, Hiroshi Suemizu

Drug Metab Pharmacokinet· June 2025

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Switch/sucrose non-fermentable complex interacts with constitutive androstane receptor to regulate drug-metabolizing enzymes and transporters in the liver.
Kiamu Kurosawa, Masataka Nakano, Itsuki Yokoseki, Mei Tomii, Yuichiro Higuchi

Drug Metab Dispos· April 2025

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Induction of drug metabolizing enzyme and drug transporter expression by antifungal triazole pesticides in human HepaSH hepatocytes.
Anna Zerdoug, Marc Le Vée, Hélène Le Mentec, Jennifer Carteret, Elodie Jouan, Yuichiro Higuchi

Chemosphere· October 2024

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Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation.
Yoshiyuki Sakai, Tatsuki Fukami, Shinsaku Tokumitsu, Masataka Nakano, Shimon Nakashima, Yuichiro Higuchi

Drug Metab Pharmacokinet· June 2024

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and Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells.
Shotaro Uehara, Norie Murayama, Yuichiro Higuchi, Makiko Shimizu, Hiroshi Suemizu

Chem Res Toxicol· May 2024

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SGX523 causes renal toxicity through aldehyde oxidase-mediated less-soluble metabolite formation in chimeric mice with humanized livers.
Shotaro Uehara, Masahiko Yasuda, Yuichiro Higuchi, Nao Yoneda, Kenji Kawai

Toxicol Lett· October 2023

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Drug transporter expression and activity in cryopreserved human hepatocytes isolated from chimeric TK-NOG mice with humanized livers.
Anna Zerdoug, Marc Le Vée, Shotaro Uehara, Agnès Jamin, Yuichiro Higuchi

Toxicol In Vitro· August 2023

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HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes.
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Ryoji Ito, Takeshi Takahashi

Biochem Biophys Res Commun· June 2023

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The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers.
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroaki Kato, Hiroshi Yamazaki

Drug Metab Dispos· April 2023

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Inhibition of nonhomologous end joining-mediated DNA repair enhances anti-HBV CRISPR therapy.
Kazuhiro Murai, Takahiro Kodama, Hayato Hikita, Akiyoshi Shimoda, Makoto Fukuoka, Yuichiro Higuchi

Hepatol Commun· September 2022

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Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism.
Shotaro Uehara, Yuichi Iida, Miyuki Ida-Tanaka, Motohito Goto, Kenji Kawai, Yuichiro Higuchi

Sci Rep· September 2022

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Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers.
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki, Hiroshi Suemizu

Drug Metab Pharmacokinet· June 2022

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Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo.
Shotaro Uehara, Makiko Shimizu, Karen Plé, Sylvain Routier, Nao Yoneda, Yuichiro Higuchi

Drug Metab Pharmacokinet· June 2022

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Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes.
Shotaro Uehara, Norie Murayama, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki

Xenobiotica· March 2022

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Capsid Allosteric Modulators Enhance the Innate Immune Response in Hepatitis B Virus-Infected Hepatocytes During Interferon Administration.
Keisuke Fukutomi, Hayato Hikita, Kazuhiro Murai, Tasuku Nakabori, Akiyoshi Shimoda, Yuichiro Higuchi

Hepatol Commun· February 2022

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An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals.
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Kenji Kawai, Masafumi Yamamoto

Drug Metab Pharmacokinet· February 2022

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Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes.
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki, Hiroshi Suemizu

Drug Metab Pharmacokinet· December 2021

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Generation of functional ciliated cholangiocytes from human pluripotent stem cells.
Mina Ogawa, Jia-Xin Jiang, Sunny Xia, Donghe Yang, Avrilynn Ding, Yuichiro Higuchi

Nat Commun· November 2021

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