Publications by authors named "Yuji Mano"

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Comprehensive assessments of pharmacokinetics and immunogenicity of farletuzumab ecteribulin, a novel antibody-drug conjugate against tumors expressing folate receptor α, in monkeys.
Shawn Fernando, Yuji Mano

J Pharm Biomed Anal· December 2025

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An LC-MS/MS Assay of Irsenontrine, a Novel Phosphodiesterase‑9 Inhibitor, in Human Plasma, Urine and Cerebrospinal Fluid for Application to Clinical Pharmacokinetic Studies.
Koichiro Hotta, Karolina Doda, Jagadeesh Aluri, Yuji Mano

ACS Omega· September 2025

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A novel selective phosphodiesterase 9 inhibitor, irsenontrine (E2027), enhances GluA1 phosphorylation in neurons and improves learning and memory via cyclic GMP elevation.
Yasuharu Ishihara, Mai Ando, Yasuaki Goto, Sadaharu Kotani, Naoto Watanabe, Yuji Mano

Neuropharmacology· August 2025

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A Simultaneous Semiquantification of Eight Immunoglobulin Isotypes in Mouse Serum by LC-MS/MS for Application of Immunogenicity Assessment of Therapeutic Antibodies.
Kiyomi Kikuchi, Muneo Aoyama, Yuji Mano

ACS Omega· June 2025

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Species-specific gene expression manipulation in humanized livers of chimeric mice via siRNA-encapsulated lipid nanoparticle treatment.
Kazuto Yamazaki, Kenji Kubara, Go Sugahara, Hiroki Muto, Masae Yamamoto, Yuji Mano

Mol Ther Methods Clin Dev· June 2025

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A simple LC-MS/MS assay for the quantification of E6011, a novel anti-fractalkine monoclonal antibody, in cynomolgus monkey serum - comparison with ligand binding assay.
Kenji Kita, Haruna Ono, Tomoko Kojima, Yuji Mano

J Pharm Biomed Anal· March 2025

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Nonclinical immunogenicity assessment of E3112, a recombinant human hepatocyte growth factor, and its impact on pharmacokinetics in rats and monkeys.
Muneo Aoyama, Yuji Mano

J Pharm Biomed Anal· January 2025

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Significant increases in detection capability for assessment of organic anion transporting polypeptide-mediated drug-drug interaction in cynomolgus monkeys by modifying pretreatment of Coproporphyrin I and III, and glycochenodeoxycholate-3-sulfate in plasma.
Takuho Ishii, Yuji Mano

Anal Chim Acta· September 2024

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Pharmacokinetic profiles of methylcobalamin in rats after multiple administration routes by a simple LC-MS/MS assay with a small volume of plasma.
Koichiro Hotta, Yuji Mano

J Pharmacol Toxicol Methods· September 2024

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Nonclinical pharmacokinetics of E3112, a recombinant human hepatocyte growth factor, in rats and monkeys by a simple ELISA kit assay.
Muneo Aoyama, Yuji Mano

J Pharmacol Toxicol Methods· July 2024

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Generic UPLC-MS/MS and Gyrolab assays with blood microsampling for pharmacokinetic assessments of therapeutic antibodies in mice.
Yuji Mano, Kenji Kita, Marina Tsugaru, Koichiro Hotta, Tomoko Kojima

J Pharm Biomed Anal· April 2024

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Development of the Complement C5 Assay by LC-MS/MS in Monkey Serum and Comparison with Enzyme-Linked Immunosorbent Assay.
Kiyomi Kikuchi, Yoko Ida, Tomohiro Yamada, Yuji Mano

ACS Omega· February 2024

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A sensitive assay for the determination of E7090, a novel selective inhibitor of fibroblast growth factor receptors, and its metabolite in human plasma by UPLC-MS/MS with at-column dilution.
Yuji Mano, Ikumi Nitanai, Koichiro Hotta

J Pharm Biomed Anal· January 2024

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Quantification of anti-drug antibodies against E6011, an anti-fractalkine monoclonal antibody, in monkey and human serum, by an electrochemiluminescence assay.
Muneo Aoyama, Yuji Mano

J Pharmacol Toxicol Methods· December 2023

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A Simple UPLC-MS/MS Assay of Rifampin in a Small Volume of Human Plasma.
Takuya Sano, Takuho Ishii, Koichiro Hotta, Yuji Mano

ACS Omega· October 2023

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Cross-species comparison in nonclinical pharmacokinetics of lenvatinib by a simple HPLC with ultraviolet detection.
Hitoshi Mizuo, Yuji Mano

Sci Rep· May 2023

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Liposome-Encapsulated Eribulin Shows Enhanced Antitumor Activity over Eribulin for Combination Therapy with Anti-PD-1 Antibody.
Yuki Niwa, Keito Adachi, Kimiyo Tabata, Ryoga Ishida, Koichiro Hotta, Yuji Mano

Mol Cancer Ther· April 2023

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A validated UPLC-MS/MS assay of E7090, a novel selective inhibitor of fibroblast growth factor receptors, in human plasma and urine.
Yoshiki Asakawa, Takuya Sano, Koichiro Hotta, Yukiko Miyajima, Yuji Mano

J Pharm Biomed Anal· February 2023

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An electrochemiluminescence assay for quantification of Denileukin Diftitox and its anti-drug antibodies in rat serum.
Yuji Mano

J Pharmacol Toxicol Methods· January 2023

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A simple UPLC-MS/MS assay with a core-shell column for the determination of exemestane in human plasma for clinical application.
Takuho Ishii, Nana Nojiri, Yuji Mano

Eur J Mass Spectrom (Chichester)· June 2022

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A separate assay of released and liposomal encapsulated eribulin in dog plasma by liquid chromatography with tandem mass spectrometry for its application to a pharmacokinetic study.
Yuji Mano

J Sep Sci· May 2022

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Quantitative and qualitative application of a novel capillary microsampling device, Microsampling Wing™ (MSW), using antiepileptic drugs in rats.
Koichiro Hotta, Tomomi Ishida, Ken-Ichi Noritake, Kenji Kita, Yuji Mano

J Pharm Biomed Anal· February 2021

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A sensitive bioanalytical assay for methylcobalamin, an endogenous and light-labile substance, in human plasma by liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study.
Koichiro Hotta, Yue Wang, Yuji Mano

J Pharm Biomed Anal· November 2020

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Establishment of a simultaneous assay for lemborexant, a novel dual orexin receptor antagonist, and its three metabolites, and its application to a clinical protein binding study.
Yuji Mano, Takashi Ueno, Koichiro Hotta

J Pharm Biomed Anal· August 2020

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Minimal impact of hepatic and renal impairment on plasma protein binding of lenvatinib, and identification of its major plasma binding protein.
Yuji Mano, Hitoshi Mizuo

Biopharm Drug Dispos· September 2019

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