Publications by authors named "Yukio Tada"

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A SARS-CoV-2 recombinant spike protein vaccine (S-268019-b) for COVID-19 prevention during the Omicron-dominant period: A phase 3, randomised, placebo-controlled clinical trial.
Vu Dinh Thiem, Pham Thi Van Anh, Chu Van Men, Do Thai Hung, Andrew J Pollard, Yukio Tada

Vaccine· June 2024

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A bias-reduced generalized estimating equation approach for proportional odds models with small-sample longitudinal ordinal data.
Yukio Tada, Tosiya Sato

BMC Med Res Methodol· June 2024

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A phase 3 randomized controlled trial of a COVID-19 recombinant vaccine S-268019-b versus ChAdOx1 nCoV-19 in Japanese adults.
Satoshi Iwata, Andrew J Pollard, Yukio Tada, Shinya Omoto, Risa Y Shibata

Sci Rep· April 2024

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Results from a preclinical study in rodents and a Phase 1/2, randomized, double-blind, placebo-controlled, parallel-group study of COVID-19 vaccine S-268019-a in Japanese adults.
Takuhiro Sonoyama, Satoshi Iwata, Masaharu Shinkai, Naoko Iwata-Yoshikawa, Nozomi Shiwa-Sudo, Yukio Tada, Tadaki Suzuki

Vaccine· March 2023

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Synthesis and Evaluation of in Vivo Anti-hypothermic Effect of the N- and C-Terminus Modified Thyrotropin-Releasing Hormone Mimetic: [(4S,5S)-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-[3-(thiazol-4-yl)-L-alanyl]-L-prolinamide.
Naotake Kobayashi, Norihito Sato, Katsuji Sugita, Tsuyoshi Kihara, Katsumi Koike, Yukio Tada

Chem Pharm Bull (Tokyo)· July 2021

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Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives.
Hiroyuki Tobinaga, Takayuki Kameyama, Kentarou Asahi, Tohru Horiguchi, Miho Oohara, Yukio Tada

Bioorg Med Chem Lett· December 2020

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Clinical Drug-Drug Interaction Studies to Evaluate the Effects of a P-Glycoprotein Inhibitor, CYP3A Inhibitors, and a CYP3A Inducer on the Pharmacokinetics of Naldemedine in Healthy Subjects.
Kazuya Fukumura, Nao Kawaguchi, Toru Ishibashi, Ryuji Kubota, Yukio Tada

Clin Drug Investig· June 2020

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Synthesis and evaluation of in vivo anti-hypothermic effect of all stereoisomers of the thyrotropin-releasing hormone mimetic: Rovatirelin Hydrate.
Naotake Kobayashi, Norihito Sato, Katsuji Sugita, Kouji Takahashi, Tamio Sugawara, Yukio Tada

J Pept Sci· December 2019

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Safety and efficacy of naldemedine in cancer patients with opioid-induced constipation: a pooled, subgroup analysis of two randomised controlled studies.
Iwao Osaka, Hiroto Ishiki, Takaaki Yokota, Yukio Tada, Hiroki Sato

ESMO Open· July 2019

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Correction to Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1-{-[(4,5)-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)-l-alanyl}-(2)-2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate).
Naotake Kobayashi, Norihito Sato, Yuko Fujimura, Tsuyoshi Kihara, Katsuji Sugita, Yukio Tada

ACS Omega· April 2019

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Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds.
Hiroyuki Tobinaga, Takayuki Kameyama, Kentarou Asahi, Tohru Horiguchi, Miho Oohara, Yukio Tada

Bioorg Med Chem Lett· March 2019

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Naldemedine in Japanese patients with opioid-induced constipation and chronic noncancer pain: open-label Phase III studies.
Yoji Saito, Takaaki Yokota, Masatsugu Arai, Yukio Tada, Masahiko Sumitani

J Pain Res· December 2018

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Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1-{-[(4,5)-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)-l-alanyl}-(2)-2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate).
Naotake Kobayashi, Norihito Sato, Yuko Fujimura, Tsuyoshi Kihara, Katsuji Sugita, Yukio Tada

ACS Omega· October 2018

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Reply to Y. Yagi et al.
Nobuyuki Katakami, Takaaki Yokota, Yukio Tada

J Clin Oncol· April 2018

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Impaired central coherence in patients with anorexia nervosa.
Sayo Hamatani, Masahito Tomotake, Tomoya Takeda, Naomi Kameoka, Masashi Kawabata, Yukio Tada

Psychiatry Res· January 2018

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Randomized Phase III and Extension Studies of Naldemedine in Patients With Opioid-Induced Constipation and Cancer.
Nobuyuki Katakami, Toshiyuki Harada, Toru Murata, Katsunori Shinozaki, Masakazu Tsutsumi, Yukio Tada

J Clin Oncol· December 2017

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Influence of cognitive function on quality of life in anorexia nervosa patients.
Sayo Hamatani, Masahito Tomotake, Tomoya Takeda, Naomi Kameoka, Masashi Kawabata, Yukio Tada

Psychiatry Clin Neurosci· May 2017

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CT-based automated planning of acetabular cup for total hip arthroplasty (THA) based on hybrid use of two statistical atlases.
Yoshiyuki Kagiyama, Itaru Otomaru, Masaki Takao, Nobuhiko Sugano, Masahiko Nakamoto, Yukio Tada

Int J Comput Assist Radiol Surg· December 2016

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Impaired social cognition in anorexia nervosa patients.
Sayo Hamatani, Masahito Tomotake, Tomoya Takeda, Naomi Kameoka, Masashi Kawabata, Yukio Tada

Neuropsychiatr Dis Treat· October 2016

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p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.
Tetsuya Saito, Yoshinobu Ichimura, Keiko Taguchi, Takafumi Suzuki, Tsunehiro Mizushima, Yukio Tada, Tadahiko Mashino

Nat Commun· June 2016

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Fluorometric assay of integrin activity with a small-molecular probe that senses the binding site microenvironment.
Toru Komatsu, Aoi Takeda, Kenjiro Hanaoka, Takuya Terai, Tasuku Ueno, Yukio Tada

Chem Commun (Camb)· December 2014

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Automated CT segmentation of diseased hip using hierarchical and conditional statistical shape models.
Futoshi Yokota, Toshiyuki Okada, Masaki Takao, Nobuhiko Sugano, Yukio Tada

Med Image Comput Comput Assist Interv· April 2014

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Selective CB2 agonists with anti-pruritic activity: discovery of potent and orally available bicyclic 2-pyridones.
Ken-ichi Kusakabe, Yasuyoshi Iso, Yukio Tada, Masahiro Sakagami, Yasuhide Morioka

Bioorg Med Chem· June 2013

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Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists.
Ken-ichi Kusakabe, Yukio Tada, Yasuyoshi Iso, Masahiro Sakagami, Yasuhide Morioka

Bioorg Med Chem· April 2013

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Rational design and development of near-infrared-emitting firefly luciferins available in vivo.
Ryosuke Kojima, Hideo Takakura, Takeaki Ozawa, Yukio Tada, Tetsuo Nagano

Angew Chem Int Ed Engl· January 2013

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