Publications by authors named "Yushe Yang"

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A practical synthesis of YZD-7082B, a novel orally bioavailable selective estrogen receptor degrader (SERD) for the treatment of ER+ breast cancer.
Yongqi He, Xin-Yu Leng, Runying Wang, Lulu Sun, Dan Zhang, Yushe Yang

Mol Divers· December 2025

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Discovery of novel Bis-amide analogue ST12 for the treatment of inflammatory bowel diseases (IBD) by inhibiting NLRP3 inflammasome activation.
Zhiqiang Sun, Qinru Zang, Chenglong Xu, Xuewen Zhang, Zhenghui Kang, Yushe Yang

Bioorg Chem· June 2025

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Discovery and optimization of novel indolecarboxylic acid derivative as potent glucagon-like peptide‑1 receptor agonists.
Wanting Zhao, Yuqian Yin, Zhuo Shi, Ke Yang, Xinglin Li, Yushe Yang

Mol Divers· May 2025

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Discovery of Thiochroman Derivatives as Potent, Oral Selective Estrogen Receptor Degraders and Antagonists for the Treatment of Endocrine-Resistant Breast Cancer.
Dan Zhang, Zhengyu Lu, Yongqi He, Xin-Yu Leng, Xin Meng, Yushe Yang

J Med Chem· December 2024

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Discovery of YFJ-36: Design, Synthesis, and Antibacterial Activities of Catechol-Conjugated β-Lactams against Gram-Negative Bacteria.
Fangjun Liu, Qunhuan Kou, Hongyuan Li, Yangzhi Cao, Meng Chen, Yushe Yang

J Med Chem· April 2024

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Design, Synthesis, and Biological Evaluation of Novel Arylomycins against Multidrug-Resistant Gram-Negative Bacteria.
Yinyong Zhang, Dan Zhang, Wenhao Zhao, Hongyuan Li, Zhengyu Lu, Yushe Yang

J Med Chem· April 2024

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Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer.
Ao Wang, Xianggang Luo, Xin Meng, Zhengyu Lu, Kaixian Chen, Yushe Yang

J Med Chem· July 2023

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Design, Synthesis, and Biological Evaluation of Androgen Receptor Degrading and Antagonizing Bifunctional Steroidal Analogs for the Treatment of Advanced Prostate Cancer.
Ao Wang, Xianggang Luo, Yawan Wang, Xin Meng, Zhengyu Lu, Yushe Yang

J Med Chem· September 2022

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Design, Synthesis, and Structure-Activity Relationship Studies of Bisamide Derivatives of Amphotericin B with Potent Efficacy and Low Toxicity.
Huijun Ma, Anran Qian, Yazhou Zheng, Xin Meng, Ting Wang, Yushe Yang

J Med Chem· July 2022

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Discovery of Thieno[2,3-]indazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability.
Zhengyu Lu, Yangzhi Cao, Dan Zhang, Xin Meng, Bin Guo, Yushe Yang

J Med Chem· April 2022

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Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens.
Qidi Kong, Wei Pan, Heng Xu, Yaru Xue, Bin Guo, Yushe Yang

J Med Chem· June 2021

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Recent advances in antibacterial agents.
Qidi Kong, Yushe Yang

Bioorg Med Chem Lett· March 2021

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Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer.
Ao Wang, Yawan Wang, Xin Meng, Yushe Yang

Bioorg Med Chem· February 2021

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Exploration of the structure-activity relationship and druggability of novel oxazolidinone-based compounds as Gram-negative antibacterial agents.
Shi Ding, Jing-Chao Ji, Ming-Juan Zhang, Yu-She Yang, Rui Wang

Arch Pharm (Weinheim)· November 2019

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Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine.
Deyu Kong, Shimeng Guo, Yushe Yang, Bin Guo, Xin Xie

Bioorg Med Chem Lett· March 2019

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Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria.
Chenghui Shi, Yinyong Zhang, Ting Wang, Wenchao Lu, Shuhua Zhang, Yushe Yang

J Med Chem· March 2019

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Optimization of P2Y Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties.
Deyu Kong, Tao Xue, Bin Guo, Jianjun Cheng, Shunyin Liu, Yushe Yang

J Med Chem· March 2019

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Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles.
Bin Guo, Shimeng Guo, Jing Huang, Jingya Li, Jia Li, Yushe Yang

Bioorg Med Chem· December 2018

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Design, synthesis and biological evaluation of C(4) substituted monobactams as antibacterial agents against multidrug-resistant Gram-negative bacteria.
Qunhuan Kou, Ting Wang, Feng Zou, Shuhua Zhang, Qian Chen, Yushe Yang

Eur J Med Chem· May 2018

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Design, synthesis, and structure-activity relationship studies of novel tetrazole antifungal agents with potent activity, broad antifungal spectrum and high selectivity.
Anran Qian, Yazhou Zheng, Ruilian Wang, Jianhai Wei, Yongmei Cui, Yushe Yang

Bioorg Med Chem Lett· February 2018

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Design, synthesis and structure-activity relationship evaluation of novel LpxC inhibitors as Gram-negative antibacterial agents.
Shi Ding, Rui-Yang Dai, Wen-Ke Wang, Qiao Cao, Le-Fu Lan, Yu-She Yang

Bioorg Med Chem Lett· January 2018

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Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
Liang Tan, Yunliang Tao, Ting Wang, Feng Zou, Shuhua Zhang, Yushe Yang

J Med Chem· April 2017

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Synthesis and structure-activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents.
Tao Xue, Shi Ding, Bin Guo, Wenjing Chu, Hui Wang, Yushe Yang

Bioorg Med Chem Lett· February 2016

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Design, synthesis, and structure-activity relationship studies of novel thienopyrrolidone derivatives with strong antifungal activity against Aspergillus fumigates.
Xufeng Cao, Yuanyuan Xu, Yongbing Cao, Ruilian Wang, Ran Zhou, Yushe Yang

Eur J Med Chem· September 2015

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Design, synthesis, and structure-activity and structure-pharmacokinetic relationship studies of novel [6,6,5] tricyclic fused oxazolidinones leading to the discovery of a potent, selective, and orally bioavailable FXa inhibitor.
Tao Xue, Shi Ding, Bin Guo, Yuren Zhou, Peng Sun, Yushe Yang

J Med Chem· September 2014

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