Publications by authors named "Yuto Unoh"

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Design, synthesis and biological evaluation of novel quinazolinedione derivatives as non-covalent SARS-CoV-2 3CL protease inhibitors.
Yoshiyuki Taoda, Akihiro Hori, Genta Tadano, Shuichi Sugiyama, Sota Masakado, Yuto Unoh

Bioorg Med Chem Lett· December 2025

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Discovery of the Clinical Candidate : A Second-Generation of SARS-CoV-2 3CL Protease Inhibitor for Treating COVID-19.
Yuto Unoh, Keiichiro Hirai, Shota Uehara, Sho Kawashima, Haruaki Nobori

J Med Chem· October 2025

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Development of a Manufacturing Process toward the Convergent Synthesis of the COVID-19 Antiviral Ensitrelvir.
Takahiro Kawajiri, Akihito Kijima, Atsuhiro Iimuro, Eisaku Ohashi, Katsuya Yamakawa, Yuto Unoh

ACS Cent Sci· April 2023

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Structure-activity relationship studies of anti-bunyaviral cap-dependent endonuclease inhibitors.
Yoshiyuki Taoda, Akihiko Sato, Shinsuke Toba, Yuto Unoh, Makoto Kawai

Bioorg Med Chem Lett· March 2023

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Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses.
Shinsuke Toba, Akihiko Sato, Makoto Kawai, Yoshiyuki Taoda, Yuto Unoh

Proc Natl Acad Sci U S A· September 2022

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Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19.
Yuto Unoh, Shota Uehara, Kenji Nakahara, Haruaki Nobori, Yukiko Yamatsu

J Med Chem· May 2022

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Phosphenium-Cation-Mediated Formal Cycloaddition Approach to Benzophospholes.
Kazutoshi Nishimura, Yuto Unoh, Koji Hirano, Masahiro Miura

Chemistry· September 2018

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Metal-Free Electrophilic Phosphination/Cyclization of Alkynes.
Yuto Unoh, Koji Hirano, Masahiro Miura

J Am Chem Soc· May 2017

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Regioselective Synthesis of Benzo[b]phosphole Derivatives via Direct ortho-Alkenylation and Cyclization of Arylthiophosphinamides.
Yuto Unoh, Yuki Yokoyama, Tetsuya Satoh, Koji Hirano, Masahiro Miura

Org Lett· October 2016

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1,2-Thiazines: One-Pot Syntheses Utilizing Mono and Diaza Analogs of Sulfones.
Rebekka Anna Bohmann, Yuto Unoh, Masahiro Miura, Carsten Bolm

Chemistry· May 2016

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Synthesis of Benzo[c]thiophenes by Rhodium(III)-Catalyzed Dehydrogenative Annulation.
Keita Fukuzumi, Yuto Unoh, Yuji Nishii, Tetsuya Satoh, Koji Hirano

J Org Chem· March 2016

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Rhodium(III)-catalyzed oxidative alkenylation of 1,3-dithiane-protected arenecarbaldehydes via regioselective C-H bond cleavage.
Yuto Unoh, Koji Hirano, Tetsuya Satoh, Masahiro Miura

Org Lett· February 2015

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Rhodium(III)-catalyzed regioselective C-H alkenylation of phenylphosphine sulfides.
Yuki Yokoyama, Yuto Unoh, Koji Hirano, Tetsuya Satoh, Masahiro Miura

J Org Chem· August 2014

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An approach to benzophosphole oxides through silver- or manganese-mediated dehydrogenative annulation involving C-C and C-P bond formation.
Yuto Unoh, Koji Hirano, Tetsuya Satoh, Masahiro Miura

Angew Chem Int Ed Engl· December 2013

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Rhodium(III)-catalyzed oxidative coupling through C-H bond cleavage directed by phosphinoxy groups.
Yuto Unoh, Yuto Hashimoto, Daisuke Takeda, Koji Hirano, Tetsuya Satoh

Org Lett· July 2013

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Palladium-catalyzed decarboxylative arylation of benzoylacrylic acids toward the synthesis of chalcones.
Yuto Unoh, Koji Hirano, Tetsuya Satoh, Masahiro Miura

J Org Chem· May 2013

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