Publications by authors named "Zenjiro Sampei"

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Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement function.
Adrian W S Ho, Taku Fukuzawa, Hikaru Koga, Ken Ohmine, Hiroki Kawauchi, Zenjiro Sampei

EBioMedicine· December 2025

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Beyond Recycling Antibodies: Crovalimab's Molecular Design Enables Four-Weekly Subcutaneous Injections for PNH Treatment.
Zenjiro Sampei, Kenta Haraya, Siok Wan Gan, Masaru Muraoka, Akira Hayasaka

Int J Mol Sci· October 2024

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A bispecific antibody NXT007 exerts a hemostatic activity in hemophilia A monkeys enough to keep a nonhemophilic state.
Yuri Teranishi-Ikawa, Tetsuhiro Soeda, Hikaru Koga, Kazuki Yamaguchi, Kazuki Kato, Zenjiro Sampei

J Thromb Haemost· February 2024

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Monte Carlo Thompson sampling-guided design for antibody engineering.
Taro Kakuzaki, Hikaru Koga, Shuuki Takizawa, Shoichi Metsugi, Hirotake Shiraiwa, Zenjiro Sampei

MAbs· November 2023

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Rapid assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4 T cell interleukin-2 secretion.
Yoshiyuki Arata, Shigeki Motoyama, Mariko Yano, Tatsuya Ikuno, Shunsuke Ito, Zenjiro Sampei

MAbs· November 2023

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Efficient production of bispecific antibody by FAST-Ig and its application to NXT007 for the treatment of hemophilia A.
Hikaru Koga, Takashi Yamano, Juan Betancur, Satoko Nagatomo, Yousuke Ikeda, Zenjiro Sampei

MAbs· June 2023

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Complement Activation by an Anti-Dengue/Zika Antibody with Impaired Fcγ Receptor Binding Provides Strong Efficacy and Abrogates Risk of Antibody-Dependent Enhancement.
Zenjiro Sampei, Christine Xing'er Koo, Frannie Jiuyi Teo, Ying Xiu Toh, Taku Fukuzawa

Antibodies (Basel)· May 2023

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Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering.
Yuji Hori, Ken Ohmine, Hitoshi Katada, Yuki Noguchi, Kazuki Sato, Zenjiro Sampei

MAbs· May 2022

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A Novel Total Drug Assay for Quantification of Anti-C5 Therapeutic Monoclonal Antibody in the Presence of Abundant Target.
Hiroo Watanabe, Mitsuko Shibuya, Norihito Shibahara, Yoshinao Ruike, Zenjiro Sampei

AAPS J· January 2021

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Correction to: A Novel Total Drug Assay for Quantification of Anti-C5 Therapeutic Monoclonal Antibody in the Presence of Abundant Target.
Hiroo Watanabe, Mitsuko Shibuya, Norihito Shibahara, Yoshinao Ruike, Zenjiro Sampei

AAPS J· January 2021

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human helper T-cell assay to screen antibody drug candidates for immunogenicity.
Shunsuke Ito, Tatsuya Ikuno, Masayuki Mishima, Mariko Yano, Toshiko Hara, Zenjiro Sampei

J Immunotoxicol· December 2019

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Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody.
Zenjiro Sampei, Kenta Haraya, Tatsuhiko Tachibana, Taku Fukuzawa, Meiri Shida-Kawazoe

PLoS One· May 2019

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Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases.
Taku Fukuzawa, Zenjiro Sampei, Kenta Haraya, Yoshinao Ruike, Meiri Shida-Kawazoe

Sci Rep· April 2017

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Non-antigen-contacting region of an asymmetric bispecific antibody to factors IXa/X significantly affects factor VIII-mimetic activity.
Zenjiro Sampei, Tomoyuki Igawa, Tetsuhiro Soeda, Miho Funaki, Kazutaka Yoshihashi

MAbs· September 2015

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Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A.
Atsushi Muto, Kazutaka Yoshihashi, Minako Takeda, Takehisa Kitazawa, Tetsuhiro Soeda, Zenjiro Sampei

Blood· November 2014

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Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity.
Zenjiro Sampei, Tomoyuki Igawa, Tetsuhiro Soeda, Yukiko Okuyama-Nishida, Chifumi Moriyama

PLoS One· September 2013

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A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model.
Takehisa Kitazawa, Tomoyuki Igawa, Zenjiro Sampei, Atsushi Muto, Tetsuo Kojima

Nat Med· October 2012

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Engineering the variable region of therapeutic IgG antibodies.
Tomoyuki Igawa, Hiroyuki Tsunoda, Taichi Kuramochi, Zenjiro Sampei, Shinya Ishii

MAbs· December 2011

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Gene cloning and deletion analysis of chitinase J from alkaliphilic Bacillus sp. strain J813.
Zenjiro Sampei, Yuri Nagao, Tetsuya Fukazawa, Satoko Fukagawa, Takatoshi Matsuo

Nucleic Acids Symp Ser (Oxf)· July 2007

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