Publications by authors named "Zhexing Wen"

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Non-Catalytic Inhibitors of the p38/MK2 Interface: Repurposing Approved Drugs to Target Neuroinflammation in Alzheimer's Disease.
Maylynn Hu, Andrew Li, Payton Fleming, Julia Gralla, Kristos Negrón Terón, Zhexing Wen

J Med Chem· December 2025

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scCotag: Diagonal integration of single-cell multi-omics data via prior-informed co-optimal transport and regularized barycentric mapping.
Yang Li, Yuting Tan, Rui Chen, Xin Maizie Zhou, You Chen, Zhexing Wen

bioRxiv· December 2025

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A non-coding RNA risk pathway in schizophrenia: miR-137 enhances the lncRNA GOMAFU through a pathological transcription network.
Peng Teng, Ying Zhou, Xingyu Ji, Yangping Li, Li Ku, Zhexing Wen

Transl Psychiatry· November 2025

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Integrative transcriptomics and network analysis reveals core genes driving meningioma pathogenesis and clinical outcomes.
Youssef M Zohdy, Ali M Alawieh, Arman Jahangiri, Benjamin Siciliano, Leonardo Tariciotti, Zhexing Wen

Sci Rep· November 2025

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Analyses of GWAS and Sub-Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk.
Rui Chen, Benjamin Siciliano, Quan Wang, Chongchong Xu, Qiang Wei, Zhexing Wen

Adv Sci (Weinh)· October 2025

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Proinflammatory transcriptomic and kinomic alterations in astrocytes derived from patients with familial Alzheimer's disease.
Benjamin Siciliano, Nicholas D Henkel, William G Ryan V, Ali Sajid Imami, John M Vergis, Zhexing Wen

Brain Behav Immun Health· August 2025

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Tensor decomposition of multi-dimensional splicing events across multiple tissues to identify splicing-mediated risk genes associated with complex traits.
Yan Yan, Rui Chen, Hakmook Kang, Yuting Tan, Anshul Tiwari, Zhexing Wen

PLoS Comput Biol· July 2025

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Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer's disease-associated proteopathology.
Ling Xie, Ryan N Sheehy, Adil Muneer, Yan Xiong, John A Wrobel, Zhexing Wen

Nat Commun· May 2025

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Multi-omics analysis reveals aspirin is associated with reduced risk of Alzheimer's disease.
Monika E Grabowska, Avi U Vaidya, Xue Zhong, Chris Guardo, Alyson L Dickson, Zhexing Wen

medRxiv· April 2025

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Patient-Derived Meningioma Organoids: A Reliable Model for Studying Human Tumor Pathophysiology.
Youssef M Zohdy, Arman Jahangiri, Fadi Jacob, Aliaksandr Aksionau, Ali M Alawieh, Zhexing Wen

Cancers (Basel)· February 2025

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Non-Invasive Quality Control of Organoid Cultures Using Mesofluidic CSTR Bioreactors and High-Content Imaging.
Seleipiri Charles, Emily Jackson-Holmes, Gongchen Sun, Ying Zhou, Benjamin Siciliano, Zhexing Wen

Adv Mater Technol· February 2025

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Longitudinal multi-omics reveals pathogenic variants disrupt developmental trajectories of human cortical organoids derived from Tuberous Sclerosis Complex.
Weibo Niu, Shaojun Yu, Xiangru Li, Zhen Wang, Rui Chen, Zhexing Wen

bioRxiv· October 2024

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Deep5hmC: predicting genome-wide 5-hydroxymethylcytosine landscape via a multimodal deep learning model.
Xin Ma, Sai Ritesh Thela, Fengdi Zhao, Bing Yao, Zhexing Wen

Bioinformatics· September 2024

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Non-invasive label-free imaging analysis pipeline for in situ characterization of 3D brain organoids.
Caroline E Serafini, Seleipiri Charles, Paloma Casteleiro Costa, Weibo Niu, Brian Cheng, Zhexing Wen

Sci Rep· September 2024

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GABAergic neuron dysregulation in a human neurodevelopmental model for major psychiatric disorders.
Ziyuan Guo, Yijing Su, Wei-Kai Huang, Xiang Sean Yao, Yan Hong, Zhexing Wen

bioRxiv· September 2024

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Neuronal-enriched small extracellular vesicles trigger a PD-L1-mediated broad suppression of T cells in Parkinson's disease.
Zhichun Chen, Wenming Li, Bo Meng, Chongchong Xu, Yiqi Huang, Zhexing Wen

iScience· July 2024

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Non-Invasive Quality Control of Organoid Cultures Using Mesofluidic CSTR Bioreactors and High-Content Imaging.
Seleipiri Charles, Emily Jackson-Holmes, Gongchen Sun, Ying Zhou, Benjamin Siciliano, Zhexing Wen

bioRxiv· July 2024

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Non-Invasive Label-free Analysis Pipeline for In Situ Characterization of Differentiation in 3D Brain Organoid Models.
Caroline Filan, Seleipiri Charles, Paloma Casteleiro Costa, Weibo Niu, Brian F Cheng, Zhexing Wen

Res Sq· April 2024

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Deep5hmC: Predicting genome-wide 5-Hydroxymethylcytosine landscape via a multimodal deep learning model.
Xin Ma, Sai Ritesh Thela, Fengdi Zhao, Bing Yao, Zhexing Wen

bioRxiv· March 2024

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Leveraging generative AI to prioritize drug repurposing candidates for Alzheimer's disease with real-world clinical validation.
Chao Yan, Monika E Grabowska, Alyson L Dickson, Bingshan Li, Zhexing Wen

NPJ Digit Med· February 2024

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FMRP phosphorylation modulates neuronal translation through YTHDF1.
Zhongyu Zou, Jiangbo Wei, Yantao Chen, Yunhee Kang, Hailing Shi, Zhexing Wen

Mol Cell· December 2023

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Leveraging iPSC technology to assess neuro-immune interactions in neurological and psychiatric disorders.
Christina Michalski, Zhexing Wen

Front Psychiatry· November 2023

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Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer's disease proteopathology for precision medication.
Xian Chen, Ling Xie, Ryan Sheehy, Yan Xiong, Adil Muneer, Zhexing Wen

Res Sq· November 2023

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Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer's disease proteopathology for precision medication.
Ling Xie, Ryan N Sheehy, Yan Xiong, Adil Muneer, John A Wrobel, Zhexing Wen

medRxiv· October 2023

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Drug repurposing for Alzheimer's disease from 2012-2022-a 10-year literature review.
Monika E Grabowska, Annabelle Huang, Zhexing Wen, Bingshan Li, Wei-Qi Wei

Front Pharmacol· September 2023

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