Publications by authors named "Zhiya Yu"

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Selective expansion of T-cell receptor engineered T cells with increased stem-like phenotypes using neoantigen stimulation.
Sanghyun P Kim, Noam Levin, Youngseo Jo, Charles Marquardt, Zhiya Yu, Hyunmi Halas

J Immunother Cancer· December 2025

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Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity.
Taisuke Kondo, François X P Bourassa, Sooraj Achar, Justyn DuSold, Pablo F Céspedes, Sanghyun P Kim, Zhiya Yu

Cell· May 2025

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Rapid enrichment of progenitor exhausted neoantigen-specific CD8 T cells from peripheral blood.
Mamduh Khateb, Raina Jung, Stav Leibou, Patrick Hadley, Zhiya Yu, Hyunmi Halas

bioRxiv· May 2025

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Identification and structural characterization of a mutant KRAS-G12V specific TCR restricted by HLA-A3.
Malcolm J W Sim, Ken-Ichi Hanada, Zachary Stotz, Zhiya Yu, Jinghua Lu

Eur J Immunol· September 2024

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Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes.
Noam Levin, Sanghyun P Kim, Charles A Marquardt, Nolan R Vale, Zhiya Yu

J Immunother Cancer· May 2024

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Identification of neoepitope reactive T-cell receptors guided by HLA-A*03:01 and HLA-A*11:01 immunopeptidomics.
Catherine M Ade, Matthew J Sporn, Sudipto Das, Zhiya Yu, Ken-Ichi Hanada, Yue A Qi

J Immunother Cancer· September 2023

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Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells.
S M Rafiqul Islam, Takuya Maeda, Naritaka Tamaoki, Meghan L Good, Rigel J Kishton, Zhiya Yu, Chengyu Liu

Cancer Res Commun· May 2023

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Adoptive Cellular Therapy with Autologous Tumor-Infiltrating Lymphocytes and T-cell Receptor-Engineered T Cells Targeting Common p53 Neoantigens in Human Solid Tumors.
Sanghyun P Kim, Nolan R Vale, Nikolaos Zacharakis, Sri Krishna, Zhiya Yu

Cancer Immunol Res· August 2022

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Cancer genes disfavoring T cell immunity identified via integrated systems approach.
Rigel J Kishton, Shashank J Patel, Amy E Decker, Suman K Vodnala, Maggie Cam, Zhiya Yu

Cell Rep· August 2022

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Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers.
Frank J Lowery, Sri Krishna, Rami Yossef, Neilesh B Parikh, Praveen D Chatani, Zhiya Yu, Sanghyun P Kim

Science· February 2022

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Identification and Validation of T-cell Receptors Targeting Hotspot Mutations in Human Cancers for Use in Cell-based Immunotherapy.
Noam Levin, Biman C Paria, Nolan R Vale, Rami Yossef, Frank J Lowery, Zhiya Yu, Sanghyun P Kim

Clin Cancer Res· September 2021

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An engineered IL-2 partial agonist promotes CD8 T cell stemness.
Fei Mo, Zhiya Yu, Peng Li, Jangsuk Oh, Rosanne Spolski, Yun Chen

Nature· September 2021

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Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer.
Sri Krishna, Frank J Lowery, Amy R Copeland, Erol Bahadiroglu, Ratnadeep Mukherjee, Zhiya Yu

Science· December 2020

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Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies.
Devikala Gurusamy, Amanda N Henning, Tori N Yamamoto, Zhiya Yu, Nikolaos Zacharakis

Cancer Cell· June 2020

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Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens.
Parisa Malekzadeh, Rami Yossef, Gal Cafri, Biman C Paria, Frank J Lowery, Sanghyun P Kim, Zhiya Yu

Clin Cancer Res· March 2020

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Identification of Small Molecule Enhancers of Immunotherapy for Melanoma.
Christopher Dextras, Myagmarjav Dashnyam, Lesley A Mathews Griner, Janani Sundaresan, Bryan Chim, Zhiya Yu

Sci Rep· March 2020

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Enhanced efficacy and limited systemic cytokine exposure with membrane-anchored interleukin-12 T-cell therapy in murine tumor models.
Ling Zhang, John S Davies, Carylinda Serna, Zhiya Yu, Nicholas P Restifo

J Immunother Cancer· January 2020

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Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells.
Ping-Hsien Lee, Tori N Yamamoto, Devikala Gurusamy, Madhusudhanan Sukumar, Zhiya Yu

J Exp Med· November 2019

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Antisense targeting of CD47 enhances human cytotoxic T-cell activity and increases survival of mice bearing B16 melanoma when combined with anti-CTLA4 and tumor irradiation.
Anthony L Schwartz, Pulak R Nath, Michael Allgauer, Elizabeth C Lessey-Morillon, John M Sipes, Zhiya Yu

Cancer Immunol Immunother· November 2019

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An effective mouse model for adoptive cancer immunotherapy targeting neoantigens.
Ken-Ichi Hanada, Zhiya Yu, Gabrielle R Chappell, Adam S Park, Nicholas P Restifo

JCI Insight· May 2019

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Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers.
Parisa Malekzadeh, Anna Pasetto, Paul F Robbins, Maria R Parkhurst, Biman C Paria, Zhiya Yu

J Clin Invest· March 2019

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The transcription factor c-Myb regulates CD8 T cell stemness and antitumor immunity.
Sanjivan Gautam, Jessica Fioravanti, Wei Zhu, John B Le Gall, Philip Brohawn, Zhiya Yu, Yun Ji

Nat Immunol· March 2019

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T cell stemness and dysfunction in tumors are triggered by a common mechanism.
Suman Kumar Vodnala, Robert Eil, Rigel J Kishton, Madhusudhanan Sukumar, Tori N Yamamoto, Zhiya Yu

Science· March 2019

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T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy.
Tori N Yamamoto, Ping-Hsien Lee, Suman K Vodnala, Devikala Gurusamy, Rigel J Kishton, Zhiya Yu

J Clin Invest· February 2019

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Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model.
Benjamin Y Jin, Tracy E Campbell, Lindsey M Draper, Sanja Stevanović, Bianca Weissbrich, Zhiya Yu

JCI Insight· April 2018

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