Publications by authors named "Zhong-Ning Lin"

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Redox-responsive chitosan hydrogel releases mitochondria-targeted fullerenol to reprogram M1/M2 macrophage balance for diabetic wound healing.
Jia-Shen Wu, Hai-Yan Huang, Lei-Lei Wang, Wei-Jie Chen, Qi Yuan, Ling Xu, Zhong-Ning Lin, Yu-Chun Lin

J Control Release· December 2025

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Hepatocyte-Derived Extracellular Vesicles Deliver miR-328-3p to Trigger PP2A-B56δ-Mediated p-NLRP3-Dependent Metaflammation in Macrophages upon Microcystin-LR Exposure.
Jia-Shen Wu, Xin-Yu Zhang, Xin-Yu Ma, Yue-Yue Wei, Lei-Lei Wang, Lin Che, Yu-Chun Lin, Zhong-Ning Lin

Adv Sci (Weinh)· November 2025

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Hepatic steatosis and pyroptosis are induced by the hepatitis B virus X protein via B56α-METTL3 interaction-mediated m6A modification of the NLRP3 mRNA.
Ze-Bang Du, Tun Han, Yu-Xin Cai, Yu-Shi Shen, Jia-Shen Wu, Zhong-Ning Lin, Yu-Chun Lin

Cell Death Dis· October 2025

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promotes malignancy of HBV-related hepatocellular carcinoma by regulating IGF2BP3-mediated nuclear-cytoplasmic shuttling.
Ze-Bang Du, Xin-Mou Wu, Tun Han, Yu-Xin Cai, Bo Qian, Yu-Chun Lin, Zhong-Ning Lin

Int J Biol Sci· August 2025

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Evaluation of the efficacy of cell-penetrating monoclonal antibodies targeting intracellular p-NLRP3 in alleviating hepatotoxicant-induced NAFLD.
Jia-Shen Wu, Yu-Qiao He, Yue-Yue Wei, Xin-Yu Ma, Xin-Yu Zhang, Zhong-Ning Lin, Yu-Chun Lin

Int J Biol Macromol· May 2025

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Palmitoylated COX-2 reprogrammed mitochondrial metabolism in pyroptotic inflammatory injury in patients with post-acute COVID-19 syndrome.
Jia-Shen Wu, Chi-Yu Xu, Su-Min Mo, Xin-Mou Wu, Ze-Bang Du, Lin Che, Yi-Ling Zhang, Zhong-Ning Lin, Yu-Chun Lin

J Adv Res· May 2025

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The involvement of SigmaR1 degradation mediated by ERAD in neural senescence linked with CdCl exposure.
Bo Qian, Ting-Yu Li, Zhao-Xuan Zheng, Han-Yu Zhang, Wen-Qi Xu, Yu-Chun Lin, Zhong-Ning Lin

J Hazard Mater· July 2024

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Aflatoxin B-exposed hepatocyte-derived extracellular vesicles: Initiating hepatic stellate cell-mediated liver fibrosis through a p53-Parkin-dependent mitophagy pathway.
Lei Yang, Yun-Lu Gao, Shan Jiang, Bo Qian, Lin Che, Yu-Chun Lin, Zhong-Ning Lin

Ecotoxicol Environ Saf· June 2024

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Interventing mitochondrial PD-L1 suppressed IFN-γ-induced cancer stemness in hepatocellular carcinoma by sensitizing sorafenib-induced ferroptosis.
Ting Li, Hai-Yan Huang, Bo Qian, Wei-Hua Wang, Qi Yuan, Jun-Lin He, Ling Xu, Yu-Chun Lin, Zhong-Ning Lin

Free Radic Biol Med· February 2024

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Protein phosphatase 2A-B55β mediated mitochondrial p-GPX4 dephosphorylation promoted sorafenib-induced ferroptosis in hepatocellular carcinoma via regulating p53 retrograde signaling.
Bo Qian, Lin Che, Ze-Bang Du, Ni-Jun Guo, Xin-Mou Wu, Ling Xu, Yu-Chun Lin, Zhong-Ning Lin

Theranostics· August 2023

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Rab7a-mTORC1 signaling-mediated cholesterol trafficking from the lysosome to mitochondria ameliorates hepatic lipotoxicity induced by aflatoxin B1 exposure.
Jin-Xian Lin, Chi-Yu Xu, Xin-Mou Wu, Lin Che, Ting-Yu Li, Zhong-Ning Lin, Yu-Chun Lin

Chemosphere· April 2023

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Aflatoxin B1 exposure triggers hepatic lipotoxicity via p53 and perilipin 2 interaction-mediated mitochondria-lipid droplet contacts: An in vitro and in vivo assessment.
Lin Che, Jing Huang, Jin-Xian Lin, Chi-Yu Xu, Xin-Mou Wu, Zhong-Ning Lin, Yu-Chun Lin

J Hazard Mater· March 2023

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Prenatal exposure to phthalates and polybrominated diphenyl ethers on neonatal health: A birth cohort study in Guangxi, China.
Bo Qian, Zhao-Xuan Zheng, Lei Yang, Cheng-Qiang Wang, Yu-Chun Lin, Zhong-Ning Lin

Environ Res· January 2023

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Intracellular antibody targeting HBx suppresses invasion and metastasis in hepatitis B virus-related hepatocarcinogenesis via protein phosphatase 2A-B56γ-mediated dephosphorylation of protein kinase B.
Lin Che, Ze-Bang Du, Wei-Hua Wang, Jia-Shen Wu, Tun Han, Ling Xu, Xu Lin, Zhong-Ning Lin, Yu-Chun Lin

Cell Prolif· November 2022

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Hepatocyte-Derived Prostaglandin E2-Modulated Macrophage M1-Type Polarization via mTOR-NPC1 Axis-Regulated Cholesterol Transport from Lysosomes to the Endoplasmic Reticulum in Hepatitis B Virus x Protein-Related Nonalcoholic Steatohepatitis.
You Lan, Bo Qian, Hai-Yan Huang, Pan Wang, Ting Li, Yu-Chun Lin, Zhong-Ning Lin

Int J Mol Sci· October 2022

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Protein phosphatase 2A-B56γ-Drp1-Rab7 signaling axis regulates mitochondria-lysosome crosstalk to sensitize the anti-cancer therapy of hepatocellular carcinoma.
Lin Che, Jia-Shen Wu, Chi-Yu Xu, Yu-Xin Cai, Jin-Xian Lin, Yu-Chun Lin, Zhong-Ning Lin

Biochem Pharmacol· August 2022

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Targeting Mitochondrial COX-2 Enhances Chemosensitivity via Drp1-Dependent Remodeling of Mitochondrial Dynamics in Hepatocellular Carcinoma.
Lin Che, Jia-Shen Wu, Ze-Bang Du, Yu-Qiao He, Lei Yang, Jin-Xian Lin, Yu-Chun Lin, Zhong-Ning Lin

Cancers (Basel)· February 2022

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MicroRNA-101 inhibits cadmium-induced angiogenesis by targeting cyclooxygenase-2 in primary human umbilical vein endothelial cells.
Lin Che, Zi-Li Wu, Lian-Yun Huang, Jia-Shen Wu, Ze-Bang Du, Jin-Xian Lin, Zhong-Ning Lin, Yu-Chun Lin

Biochem Pharmacol· July 2021

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Mitochondrial redox-driven mitofusin 2 S-glutathionylation promotes neuronal necroptosis via disrupting ER-mitochondria crosstalk in cadmium-induced neurotoxicity.
Lin Che, Chuan-Li Yang, Yu Chen, Zi-Li Wu, Ze-Bang Du, Cong-Ling Gan, Yu-Chun Lin, Zhong-Ning Lin

Chemosphere· January 2021

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Cyclooxygenase-2 modulates ER-mitochondria crosstalk to mediate superparamagnetic iron oxide nanoparticles induced hepatotoxicity: an and study.
Lin Che, Huan Yao, Chuan-Li Yang, Ni-Jun Guo, Jing Huang, Zhong-Ning Lin, Yu-Chun Lin

Nanotoxicology· March 2020

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BNIP3L-Dependent Mitophagy Promotes HBx-Induced Cancer Stemness of Hepatocellular Carcinoma Cells via Glycolysis Metabolism Reprogramming.
Yuan-Yuan Chen, Wei-Hua Wang, Lin Che, You Lan, Li-Yin Zhang, Deng-Lin Zhan, Zhong-Ning Lin, Yu-Chun Lin

Cancers (Basel)· March 2020

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Chinese herb feed additives improved the growth performance, meat quality, and nutrient digestibility parameters of pigs.
Zhong-Ning Lin, Li Ye, Zhen-Wu Li, Xiu-Sheng Huang, Zheng Lu

Animal Model Exp Med· March 2020

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Aflatoxin B1 enhances pyroptosis of hepatocytes and activation of Kupffer cells to promote liver inflammatory injury via dephosphorylation of cyclooxygenase-2: an in vitro, ex vivo and in vivo study.
Li-Yin Zhang, Deng-Lin Zhan, Yuan-Yuan Chen, Wei-Hua Wang, Cheng-Yong He, Yi Lin, Yu-Chun Lin, Zhong-Ning Lin

Arch Toxicol· November 2019

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HBx combined with AFB1 triggers hepatic steatosis via COX-2-mediated necrosome formation and mitochondrial dynamics disorder.
Yuan-Yuan Chen, Yi Lin, Pei-Yu Han, Shan Jiang, Lin Che, Yu-Chun Lin, Zhong-Ning Lin

J Cell Mol Med· September 2019

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Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related protein 1.
Teng-Jian Zhou, Shi-Li Zhang, Cheng-Yong He, Qun-Ying Zhuang, Pei-Yu Han, Wen-Hua Ling, Yu-Chun Lin, Zhong-Ning Lin

Theranostics· January 2018

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