Publications by authors named "Zhuchi Tu"

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Alleviation of mutant TDP-43-mediated neuropathology by inducible stem cells in monkeys.
Xichen Song, Caijuan Li, Yang Yang, Chunhui Huang, Min Chen, Zhuchi Tu

Int J Biol Sci· December 2025

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Primate ASPM knockout causes severe microcephaly and oligodendrocyte loss in the brain.
Dajian He, Mingtian Pan, Fengwei Sun, Liang Jiang, Qintian Guo, Zhuchi Tu

Protein Cell· November 2025

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A Novel Genetic TDP-43 Pig Model Mimics Multiple Key ALS-Like Features.
Chunhui Huang, Xiao Zheng, Jiaxi Wu, Jiawei Li, Yingqi Lin, Zhuchi Tu

MedComm (2020)· September 2025

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RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington's disease models.
Yingqi Lin, Caijuan Li, Yizhi Chen, Jiale Gao, Jiawei Li, Zhuchi Tu

Mol Neurodegener· January 2025

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Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models.
Rui Han, Qi Wang, Xin Xiong, Xiusheng Chen, Zhuchi Tu

J Clin Invest· October 2024

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Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta.
Chen Zhang, Qingqing Jia, Longhong Zhu, Junqi Hou, Xiang Wang, Zhuchi Tu

Alzheimers Dement· September 2024

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Large animal models for Huntington's disease research.
Bofeng Han, Weien Liang, Xiao-Jiang Li, Shihua Li, Sen Yan, Zhuchi Tu

Zool Res· March 2024

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A Specific Mini-Intrabody Mediates Lysosome Degradation of Mutant Huntingtin.
Caijuan Li, Yingqi Lin, Yizhi Chen, Xichen Song, Xiao Zheng, Zhuchi Tu

Adv Sci (Weinh)· November 2023

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Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing.
Xiao Zheng, Chunhui Huang, Yingqi Lin, Bofeng Han, Yizhi Chen, Zhuchi Tu

Signal Transduct Target Ther· September 2023

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Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys.
Zhuchi Tu, Sen Yan, Bofeng Han, Caijuan Li, Weien Liang

Signal Transduct Target Ther· September 2023

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Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington's disease.
Sen Yan, Xiao Zheng, Yingqi Lin, Caijuan Li, Zhaoming Liu, Zhuchi Tu

Nat Biomed Eng· May 2023

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CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate.
Bang Li, Hui Zhao, Zhuchi Tu, Weili Yang, Rui Han

Cell Discov· March 2023

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Intravenous AAV9 administration results in safe and widespread distribution of transgene in the brain of mini-pig.
Yingqi Lin, Caijuan Li, Wei Wang, Jiawei Li, Chunhui Huang, Zhuchi Tu

Front Cell Dev Biol· January 2023

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Application of CRISPR/Cas9 System in Establishing Large Animal Models.
Yingqi Lin, Jun Li, Caijuan Li, Zhuchi Tu, Shihua Li

Front Cell Dev Biol· May 2022

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PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis.
Weili Yang, Xiangyu Guo, Zhuchi Tu, Xiusheng Chen, Rui Han

Protein Cell· January 2022

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Differential development and electrophysiological activity in cultured cortical neurons from the mouse and cynomolgus monkey.
Xue-Yan Zhang, Jun Li, Cai-Juan Li, Ying-Qi Lin, Chun-Hui Huang, Zhu-Chi Tu

Neural Regen Res· December 2021

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TBN improves motor function and prolongs survival in a TDP-43M337V mouse model of ALS.
Chunhui Huang, Jun Li, Guiliang Zhang, Yingqi Lin, Caijuan Li, Zhuchi Tu

Hum Mol Genet· July 2021

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Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates.
Hui Zhao, Qiqi Wang, Ting Yan, Yu Zhang, Hui-Juan Xu, Zhuchi Tu

Transl Psychiatry· October 2019

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CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys.
Weili Yang, Yunbo Liu, Zhuchi Tu, Chong Xiao, Sen Yan

Cell Res· April 2019

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CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms.
Zhuchi Tu, Hui Zhao, Bang Li, Sen Yan, Lu Wang

Hum Mol Genet· February 2019

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A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington's Disease.
Sen Yan, Zhuchi Tu, Zhaoming Liu, Nana Fan, Huiming Yang

Cell· May 2018

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Use of CRISPR/Cas9 to model brain diseases.
Sen Yan, Zhuchi Tu, Shihua Li, Xiao-Jiang Li

Prog Neuropsychopharmacol Biol Psychiatry· February 2018

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Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3-deficient non-human primate.
Hui Zhao, Zhuchi Tu, Huijuan Xu, Sen Yan, Huanhuan Yan

Cell Res· October 2017

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CRISPR: Established Editor of Human Embryos?
Xiao-Jiang Li, Zhuchi Tu, Weili Yang, Shihua Li

Cell Stem Cell· September 2017

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Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos.
Zhuchi Tu, Weili Yang, Sen Yan, An Yin, Jinquan Gao

Sci Rep· February 2017

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