Publications by authors named "Zoltan Ivics"

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Generation and GMP scale-up of human CAR-T cells using non-viral transposons for B cell malignances.
Begoña Diez, Cristina Calviño, María Fernández-García, Paula Rodríguez-Márquez, Saray Rodríguez-Díaz, Zoltán Ivics

Mol Ther Methods Clin Dev· March 2025

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DNA binding and transposition activity of the Sleeping Beauty transposase: role of structural stability of the primary DNA-binding domain.
Venkatesh V Ranjan, Gage O Leighton, Chenbo Yan, Maria Arango, Janna Lustig, Zoltán Ivics

Nucleic Acids Res· January 2025

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A novel hyperactive variant of the transposase facilitates non-viral genome engineering.
Matthias Thomas Ochmann, Csaba Miskey, Lacramioara Botezatu, Nicolás Sandoval-Villegas, Tanja Diem, Zoltán Ivics

Mol Ther Nucleic Acids· December 2024

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The best of both worlds: AAV-mediated gene transfer empowered by LNP delivery of Sleeping Beauty transposase for durable transgene expression in vivo.
Nicolás Sandoval-Villegas, Zoltán Ivics

Mol Ther· October 2024

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An LNP-CRISPR gene editing drug demonstrates efficacy and safety in patients with hereditary angioedema following in vivo administration.
Norbert Pardi, Zoltán Ivics

J Allergy Clin Immunol· August 2024

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Engineering of potent CAR NK cells using non-viral Sleeping Beauty transposition from minimalistic DNA vectors.
Tobias Bexte, Lacramioara Botezatu, Csaba Miskey, Fenja Gierschek, Alina Moter, Zoltán Ivics

Mol Ther· July 2024

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Spatiotemporal analysis of SARS-CoV-2 infection reveals an expansive wave of monocyte-derived macrophages associated with vascular damage and virus clearance in hamster lungs.
Ola Bagato, Anne Balkema-Buschmann, Daniel Todt, Saskia Weber, André Gömer, Zoltan Ivics

Microbiol Spectr· January 2024

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Generation of four gene-edited human induced pluripotent stem cell lines with mutations in the ATM gene to model Ataxia-Telangiectasia.
Wasifa Nurieva, Elena Ivanova, Sanabel Chehab, Parth Singh, Marina Reichlmeir, Zoltán Ivics

Stem Cell Res· December 2023

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Accelerating development of engineered T cell therapies in the EU: current regulatory framework for studying multiple product versions and T2EVOLVE recommendations.
Delphine Ammar, Inga Schapitz, Maik Luu, Michael Hudecek, Miriam Meyer, Zoltán Ivics

Front Immunol· December 2023

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In Cerebellar Atrophy of 12-Month-Old ATM-Null Mice, Transcriptome Upregulations Concern Most Neurotransmission and Neuropeptide Pathways, While Downregulations Affect Prominently Itpr1, Usp2 and Non-Coding RNA.
Marina Reichlmeir, Júlia Canet-Pons, Gabriele Koepf, Wasifa Nurieva, Ruth Pia Duecker, Zoltán Ivics

Cells· October 2023

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Transposon Insertions into Nucleolar DNA by an Engineered Transposase Localized in the Nucleolus.
Adrian Kovač, Csaba Miskey, Zoltán Ivics

Int J Mol Sci· October 2023

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Anti-CD117 CAR T cells incorporating a safety switch eradicate human acute myeloid leukemia and hematopoietic stem cells.
Chiara F Magnani, Renier Myburgh, Silvan Brunn, Morgane Chambovey, Marianna Ponzo, Zoltán Ivics

Mol Ther Oncolytics· September 2023

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Erratum: Anti-CD117 CAR T cells incorporating a safety switch eradicate human acute myeloid leukemia and hematopoietic stem cells.
Chiara F Magnani, Renier Myburgh, Silvan Brunn, Morgane Chambovey, Marianna Ponzo, Zoltán Ivics

Mol Ther Oncolytics· September 2023

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Downregulation of transposable elements extends lifespan in Caenorhabditis elegans.
Ádám Sturm, Éva Saskői, Bernadette Hotzi, Anna Tarnóci, János Barna, Zoltán Ivics

Nat Commun· August 2023

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HMGXB4 Targets Transposition to Germinal Stem Cells.
Anantharam Devaraj, Manvendra Singh, Suneel A Narayanavari, Guo Yong, Jiaxuan Chen, Zoltán Ivics

Int J Mol Sci· April 2023

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Enhanced Biosafety of the Transposon System by Using mRNA as Source of Transposase to Efficiently and Stably Transfect Retinal Pigment Epithelial Cells.
Nina Harmening, Sandra Johnen, Zsuzsanna Izsvák, Zoltan Ivics, Martina Kropp

Biomolecules· April 2023

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Second hepatitis C virus transmission by blood components since introduction of mandatory NAT screening in Germany.
Kiyoshi Himmelsbach, Susanne Mueller, Julia Kress, Sarah A Fiedler, Csaba Miskey, Zoltan Ivics

Transfusion· February 2023

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Passer, a highly active transposon from a fish genome, as a potential new robust genetic manipulation tool.
Saisai Wang, Bo Gao, Csaba Miskey, Zhongxia Guan, Yatong Sang, Zoltán Ivics

Nucleic Acids Res· February 2023

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GMP-Grade Manufacturing and Quality Control of a Non-Virally Engineered Advanced Therapy Medicinal Product for Personalized Treatment of Age-Related Macular Degeneration.
Martina Kropp, Nina Harmening, Thais Bascuas, Sandra Johnen, Eline De Clerck, Zoltan Ivics

Biomedicines· November 2022

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Horizontal Transfer and Evolutionary Profiles of Two DD34E Transposons ( and ) in Vertebrates.
Wenzhu Jia, Emmanuel Asare, Tao Liu, Pingjing Zhang, Yali Wang, Zoltán Ivics

Genes (Basel)· November 2022

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Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output.
Marcel G E Rommel, Lisa Walz, Foteini Fotopoulou, Saskia Kohlscheen, Franziska Schenk, Zoltán Ivics

Cell Rep· October 2022

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Molecular and Functional Characterization of BDNF-Overexpressing Human Retinal Pigment Epithelial Cells Established by Transposon-Mediated Gene Transfer.
Larissa Mattern, Katrin Otten, Csaba Miskey, Matthias Fuest, Zsuzsanna Izsvák, Zoltán Ivics

Int J Mol Sci· October 2022

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Functional Characterization of the N-Terminal Disordered Region of the Transposase.
Gerda Wachtl, Éva Schád, Krisztina Huszár, Antonio Palazzo, Zoltán Ivics

Int J Mol Sci· September 2022

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Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after T2-biased immunization.
Aileen Ebenig, Samada Muraleedharan, Julia Kazmierski, Daniel Todt, Arne Auste, Zoltan Ivics

Cell Rep· August 2022

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