PubHawk
Ann N Y Acad Sci June 2000 PMID 10911963

Inflamm-aging. An evolutionary perspective on immunosenescence.

C Franceschi, M Bonafè, S Valensin, F Olivieri, M De Luca, E Ottaviani, G De Benedictis

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Mentions

95
Peak: 2 in Aug 2022
across 5 sources since Aug 2022

Extended reach

125,550
potential audience

Total likes

79

Video views

779

Mentions per month

Aug 2022 – Oct 2025

Where it's discussed

  • News74 articles
  • Blogs9 articles
  • X / Twitter7 posts
  • Facebook3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The comments indicate a shared understanding of inflammaging as a chronic, low-grade inflammation linked to aging and stress, supported by references to the publication and related concepts like geroscience. The tone remains professional and academic, with some posts highlighting the importance of the research, but there are few detailed critiques or new insights, reflecting moderate engagement and interest.

AgreementModerate agreement

Most discussions recognize the significance of inflammaging and its role in aging, showing general support for the publication's ideas.

InterestModerate interest

Participants seem moderately interested, as evident from the focus on core concepts like inflammaging and references to fundamental authors.

EngagementNeutral engagement

The level of engagement appears to be moderate, with some mentions of the terminology and basic explanations, but limited deep analysis.

ImpactModerate impact

The discussions suggest that the publication has a meaningful influence within the academic and scientific communities interested in aging and immunology.

Abstract in brief

  • The paper extends the network theory of aging, suggesting that aging involves a decline in the body's ability to handle stress and a rise in inflammation, called inflammaging, driven by continuous exposure to antigens and stressors.
  • It argues that immune responses and stress responses are similar, with macrophages playing a key role in both inflammation and stress management, and that genetic factors influence how quickly inflammaging progresses and its impact on age-related diseases.
  • The concept explains why, in older age, inflammation—initially protective—becomes harmful, contributing to diseases like Alzheimer’s and diabetes, with the persistence of inflammatory stimuli over time increasing vulnerability, aligning with the antagonistic pleiotropy theory of aging.]
Read the full abstract

Top posts

Most liked on X and Bluesky
La Jefita
@soylajefita · X

No es una inflamación aguda y “útil”, como la que aparece cuando te cortas o tienes una infección en la garganta. Es una inflamación crónica, estéril y de bajo grado. https://t.co/BU1xAgatrd

Sep 27, 2025 · 47 likes · 2 shares · 78,690 followers View post →
Agingdoc
@agingdoc1 · X

Inflamm-aging. An evolutionary perspective on immunosenescence https://t.co/evwdDZbYqs With the @agingdoc1 theme today focusing on geroscience via the lens of immunity, this classic by Claudio Franceschi & colleagues is apropos conceptualizing & coining the term

Aug 14, 2022 · 1 like · 43,826 followers View post →
La Piel de Zapa
@lamemur · X

RT @soylajefita: No es una inflamación aguda y “útil”, como la que aparece cuando te cortas o tienes una infección en la garganta. Es una i…

Oct 18, 2025 · 2 shares · 1,471 followers View post →
AAPMD
@AAPMDorg · X

INFLAMMAGING! https://t.co/DEBnx91jOV

Jan 20, 2023 · 362 followers View post →
AAPMD
@AAPMDorg · X

INFLAMMAGING https://t.co/zC5ivGbYVh

Aug 5, 2022 · 362 followers View post →
Ezequiel M. Fuentes Pananá
@FuentesPanana · X

Fuentes https://t.co/7DEHhw1app https://t.co/Ub9TPitDxL https://t.co/Xe0SzRcKJn https://t.co/ziDJCiJiWT https://t.co/aVfJVzEu06

Jan 24, 2025 · 37 followers View post →

All mentions

La Piel de Zapa
@lamemur · X

RT @soylajefita: No es una inflamación aguda y “útil”, como la que aparece cuando te cortas o tienes una infección en la garganta. Es una i…

Oct 18, 2025 · 2 shares · 1,471 followers View post →
La Jefita
@soylajefita · X

No es una inflamación aguda y “útil”, como la que aparece cuando te cortas o tienes una infección en la garganta. Es una inflamación crónica, estéril y de bajo grado. https://t.co/BU1xAgatrd

Sep 27, 2025 · 47 likes · 2 shares · 78,690 followers View post →
Ezequiel M. Fuentes Pananá
@FuentesPanana · X

Fuentes https://t.co/7DEHhw1app https://t.co/Ub9TPitDxL https://t.co/Xe0SzRcKJn https://t.co/ziDJCiJiWT https://t.co/aVfJVzEu06

Jan 24, 2025 · 37 followers View post →
R.KSingh
@RKSingh18587012 · X

Inflamm-aging. An evolutionary perspective on immunosenescence - PubMed https://t.co/3QNmBd1spc

Mar 2, 2023 · 16 followers View post →
AAPMD
@AAPMDorg · X

INFLAMMAGING! https://t.co/DEBnx91jOV

Jan 20, 2023 · 362 followers View post →
Agingdoc
@agingdoc1 · X

Inflamm-aging. An evolutionary perspective on immunosenescence https://t.co/evwdDZbYqs With the @agingdoc1 theme today focusing on geroscience via the lens of immunity, this classic by Claudio Franceschi & colleagues is apropos conceptualizing & coining the term

Aug 14, 2022 · 1 like · 43,826 followers View post →
AAPMD
@AAPMDorg · X

INFLAMMAGING https://t.co/zC5ivGbYVh

Aug 5, 2022 · 362 followers View post →