PubHawk
Am J Psychiatry October 2000 PMID 11007705

Genetic epidemiology of major depression: review and meta-analysis.

P F Sullivan, M C Neale, K S Kendler

Full text PDF Download social card

Mentions

41
Peak: 5 in Sep 2019
across 4 sources since Aug 2019

Extended reach

105,394
potential audience

Total likes

38

Video views

443

Mentions per month

Aug 2019 – Jun 2025

Where it's discussed

  • News18 articles
  • X / Twitter15 posts
  • Blogs5 articles
  • YouTube3 videos

AI synopsis

What people are saying

The discussions collectively affirm the importance of genetics in depression, with examples like references to heritability estimates (around 37%), and discussions of twin studies, emphasizing the significance of genetic influences. The tone is scholarly yet accessible, reflecting both respect for the research and curiosity about its implications.

AgreementStrong agreement

Many posts explicitly acknowledge the genetic role in major depression, citing heritability estimates and twin studies, showing strong consensus.

InterestHigh interest

The discussions reveal high curiosity about the genetic aspects, with references to specific studies and data, indicating active interest.

EngagementModerate engagement

While some comments dive into detailed interpretations, others simply support the findings, showing moderate engagement depth.

ImpactHigh impact

The frequent mentions of the publication’s findings and their significance highlight that users perceive this research as impactful in understanding depression.

Abstract in brief

  • The meta-analysis reviewed family, adoption, and twin studies to understand the genetic factors contributing to major depression, finding strong evidence that genetics play a significant role.
  • Family and twin studies showed that major depression tends to run in families mainly due to additive genetic effects, with heritability estimates around 37%.
  • While genetics are important, individual environmental factors also contribute significantly, making major depression a complex disorder caused by an interplay of genetic and environmental influences.]
Read the full abstract

Top posts

Most liked on X and Bluesky
PGC Consortium
@PGCgenetics · X

Does depression have a genetic component? Yes! From twin studies, major depressive disorder has a heritability of 37%. Moderate, but much lower than for schizophrenia or bipolar disorder https://t.co/wNoKUEZfts https://t.co/heczJbO19j

Sep 3, 2019 · 12 likes · 5 shares · 5,652 followers View post →
Kyō
@KyosanAU · X

@sneako You're wrong champ sorry 10.1176/appi.ajp.157.10.1552 https://t.co/bvu0h98d7b

Jan 11, 2023 · 12 likes · 760 followers View post →
นิรนาม: Winter Heptagon
@Ahgasup · X

@uavs_g @Xx_sh0o @callmexmimi @sridi_15 https://t.co/14FiZCfUIK (สิ่งนี้) เป็นงายวิจัยที่ทางนี้ยังไม่ได้ไปอ่านว่าน่าเชื่อถือหรือไม่ แต่ได้นำงานวิจัยสมัย 19xx มารวมแล้วสรุปว่า อย่างไรโรคนี้ก็มีปัจจัยพันธุกรรมเกี่ยวข้องนั่นเอง แต่เวลาแยะนำแก่ประชากรทั่วไป อย่างไรก็ควรเป็นการบอกว่าจากหลายสาเหตุร่วมกัน มิใชทางใด (+)

Oct 3, 2024 · 2 likes · 57 followers View post →
いっちー@バーチャル精神科医
@ichiipsy · X

@saori__________ あくまで遺伝率なので、遺伝的にうつ病の家系では、うつ病になりやすいという話です。 https://t.co/YuT0ozykzF

Aug 19, 2019 · 1 like · 78,973 followers View post →
jacob
@fortune259 · X

@MistersHomeRoom @char5191 @Lucifer_mortala @BarbB2013 @thepeacepoet99 https://t.co/Gp2I54XdTl https://t.co/UKQsuXIFOh https://t.co/oUhWnQNyx6 https://t.co/7PrhK7o6NF

Dec 27, 2024 · 1 like · 437 followers View post →
Cynthia Bulik
@cbulik · X

RT @PGCgenetics: Does depression have a genetic component? Yes! From twin studies, major depressive disorder has a heritability of 37%.…

Sep 3, 2019 · 5 shares · 8,385 followers View post →

All mentions

こころと生きる
@kokoro_to_ikiru · X

Jun 1, 2025 · 1 share · 46 followers View post →
Ineffable Stuff
@ineffable_stuff · X

@malemovich @madeinbajor tô chocada que tem gente de fato pedindo essas referências, seria difícil achar o oposto. Depressão: https://t.co/drS64kVhNp Bipolaridade: https://t.co/XStoIj4q2M TOC https://t.co/LWMkvqwoPx TDAH https://t.co/elPK7igxBk E muita gente aí já mandou de esquizofrenia

Feb 1, 2025 · 168 followers View post →
jacob
@fortune259 · X

@MistersHomeRoom @char5191 @Lucifer_mortala @BarbB2013 @thepeacepoet99 https://t.co/Gp2I54XdTl https://t.co/UKQsuXIFOh https://t.co/oUhWnQNyx6 https://t.co/7PrhK7o6NF

Dec 27, 2024 · 1 like · 437 followers View post →
นิรนาม: Winter Heptagon
@Ahgasup · X

@uavs_g @Xx_sh0o @callmexmimi @sridi_15 https://t.co/14FiZCfUIK (สิ่งนี้) เป็นงายวิจัยที่ทางนี้ยังไม่ได้ไปอ่านว่าน่าเชื่อถือหรือไม่ แต่ได้นำงานวิจัยสมัย 19xx มารวมแล้วสรุปว่า อย่างไรโรคนี้ก็มีปัจจัยพันธุกรรมเกี่ยวข้องนั่นเอง แต่เวลาแยะนำแก่ประชากรทั่วไป อย่างไรก็ควรเป็นการบอกว่าจากหลายสาเหตุร่วมกัน มิใชทางใด (+)

Oct 3, 2024 · 2 likes · 57 followers View post →
sam
@e_libertas · X

@anthonyzenkus This is not accurate. https://t.co/ZYiCA4pefm

Jun 20, 2024 · 488 followers View post →
Remi | Speech & Debate Guy
@Remithedebater · X

@cadams_creative @CopywritingAG Sullivan PF, Neale MC, Kendler KS. Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry. 2000;157(10):1552-1562. doi:10.1176/appi.ajp.157.10.1552

Jan 7, 2024 · 174 followers View post →
Kyō
@KyosanAU · X

@sneako You're wrong champ sorry 10.1176/appi.ajp.157.10.1552 https://t.co/bvu0h98d7b

Jan 11, 2023 · 12 likes · 760 followers View post →
Karl C. Mayer
@Neuro24de · X

@Martin_Ploederl @mellemrum @HengartnerMP @wolicyponk Major depression is a familial disorder, and its familiality mostly or entirely results from genetic influences. https://t.co/DOjJQQKJvY Heritability was high in childhood and decreased to 30-40% during adulthood. https://t.co/Ol18Qxy4Aa

May 20, 2020 · 1,321 followers View post →
Karl C. Mayer
@Neuro24de · X

@Martin_Ploederl @mellemrum @HengartnerMP @wolicyponk Major depression is a familial disorder, and its familiality mostly or entirely results from genetic influences. https://t.co/DOjJQQKJvY Heritability was high in childhood and decreased to 30-40% during adulthood. https://t.co/Ol18Qxy4Aa

May 20, 2020 · 1,321 followers View post →
Samuele Cortese
@CorteseSamuele · X

RT @PGCgenetics: Does depression have a genetic component? Yes! From twin studies, major depressive disorder has a heritability of 37%.…

Sep 4, 2019 · 5 shares · 3,957 followers View post →
Cynthia Bulik
@cbulik · X

RT @PGCgenetics: Does depression have a genetic component? Yes! From twin studies, major depressive disorder has a heritability of 37%.…

Sep 3, 2019 · 5 shares · 8,385 followers View post →
Anna Docherty
@bunsenmercury · X

RT @PGCgenetics: Does depression have a genetic component? Yes! From twin studies, major depressive disorder has a heritability of 37%.…

Sep 3, 2019 · 5 shares · 613 followers View post →
S Meltzer-Brody
@smeltzerb · X

RT @PGCgenetics: Does depression have a genetic component? Yes! From twin studies, major depressive disorder has a heritability of 37%.…

Sep 3, 2019 · 5 shares · 2,548 followers View post →
PGC Consortium
@PGCgenetics · X

Does depression have a genetic component? Yes! From twin studies, major depressive disorder has a heritability of 37%. Moderate, but much lower than for schizophrenia or bipolar disorder https://t.co/wNoKUEZfts https://t.co/heczJbO19j

Sep 3, 2019 · 12 likes · 5 shares · 5,652 followers View post →
いっちー@バーチャル精神科医
@ichiipsy · X

@saori__________ あくまで遺伝率なので、遺伝的にうつ病の家系では、うつ病になりやすいという話です。 https://t.co/YuT0ozykzF

Aug 19, 2019 · 1 like · 78,973 followers View post →