Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA.

A E Pasquinelli, B J Reinhart, F Slack, M Q Martindale, M I Kuroda, B Maller, D C Hayward, E E Ball, B Degnan, P Müller, J Spring, A Srinivasan, M Fishman, J Finnerty, J Corbo

November 2000 Nature

Synopsis of Social media discussions

The overall tone reflects curiosity and appreciation, with posts describing the article as revealing key roles of conserved RNA molecules like let-7 in development. Words such as 'fundamental,' 'conserved,' and 'universal' highlight the perceived importance, though the conversations mostly focus on general interest rather than detailed critique or implications.

A
Agreement
 Moderate agreement

Most discussions acknowledge the importance of the research, with some expressing appreciation for the foundational insights into evolutionarily conserved RNAs.

I
Interest
 High level of interest

Posts demonstrate high curiosity about the implications of let-7 RNA across species, indicating strong interest in developmental biology and evolutionary conservation.

E
Engagement
 Neutral engagement

While some comments reference specific findings and authors, many discussions remain surface-level, showing moderate engagement rather than deep technical analysis.

I
Impact
 Moderate level of impact

The discussions hint at the broad significance of these RNAs in developmental regulation, but few comments explicitly emphasize widespread scientific or medical impact.

Social Mentions

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2 Videos

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5 Posts

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8 Articles

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35 Articles

Metrics

Video Views

66,147

Total Likes

4,141

Extended Reach

80,965

Social Features

50

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

MicroRNA Discovery and its Impact on Nobel Medicine Award 2024

MicroRNA Discovery and its Impact on Nobel Medicine Award 2024

This video discusses how small RNA molecules, lin4 and let7, regulate developmental stages in C. elegans, highlighting the universal role of conserved let7 RNAs in animal development and their implications for medicine.

Anton Petrov

October 19, 2024

66,095 views

MicroRNA Discovery and Its Significance in Modern Biology

MicroRNA Discovery and Its Significance in Modern Biology

This video discusses how small RNAs like lin4 and let7 regulate developmental stages in C. elegans, highlighting the evolutionary conservation of let7 and its essential role in controlling developmental timing across animals.

Biology

October 7, 2024

53 views

  • Dr. Jason Begalke
    @DrJasonBegalke (Twitter)

    Reading: https://t.co/tbowvUZ2q6 https://t.co/0YxCCA7Wew https://t.co/AopRVKLysN #Medicine #STEAM #NLM #NIH
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  • Shigeru Flower-Field
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    RT @souyakuchan: 主たる成果論文。いわゆる back-to-back 掲載というやつ。Cell 誌。 Cell, 75(5), pp. 843–854. Victor Ambros et al. https://t.co/PLw57884Cy Cell, 75…
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    @howling18 (Twitter)

    RT @souyakuchan: 主たる成果論文。いわゆる back-to-back 掲載というやつ。Cell 誌。 Cell, 75(5), pp. 843–854. Victor Ambros et al. https://t.co/PLw57884Cy Cell, 75…
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  • 藪出毬
    @M_Banba_ (Twitter)

    RT @souyakuchan: 主たる成果論文。いわゆる back-to-back 掲載というやつ。Cell 誌。 Cell, 75(5), pp. 843–854. Victor Ambros et al. https://t.co/PLw57884Cy Cell, 75…
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    October 7, 2024

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  • 叢雲くすり (創薬ちゃん)
    @souyakuchan (Twitter)

    主たる成果論文。いわゆる back-to-back 掲載というやつ。Cell 誌。 Cell, 75(5), pp. 843–854. Victor Ambros et al. https://t.co/PLw57884Cy Cell, 75(5), pp. 855–862. Gary Ruvkun et al. https://t.co/dJkXOApB2B Nature, 408(6808), pp. 86–89. Gary Ruvkun et al. https://t.co/j1B5DmNHad
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    October 7, 2024

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Abstract Synopsis

  • The study discusses how two small RNA molecules, lin4 and let7, regulate key developmental stages in the nematode C. elegans, with lin4 acting during early larval stages and let7 during later stages.
  • let7 RNA is evolutionarily conserved and found in various animal species, including vertebrates and invertebrates, indicating its fundamental role in developmental timing, while lin4 is not detected outside nematodes.
  • The findings suggest that let7 RNAs may play a universal role across animals in controlling late-stage developmental transitions, given their conserved expression patterns at specific developmental stages across diverse species.]