PubHawk
Nature November 2000 PMID 11081512

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA.

A E Pasquinelli, B J Reinhart, F Slack, M Q Martindale, M I Kuroda, B Maller, D C Hayward, E E Ball, B Degnan, P Müller, J Spring, A Srinivasan, M Fishman, J Finnerty, J Corbo

Full text PDF Download social card

Mentions

50
Peak: 7 in Oct 2024
across 4 sources since Oct 2024

Extended reach

80,965
potential audience

Total likes

4,141

Video views

66,147

Mentions per month

Oct 2024

All 7 dated mentions so far are from Oct 2024.

Where it's discussed

  • News35 articles
  • Blogs8 articles
  • X / Twitter5 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone reflects curiosity and appreciation, with posts describing the article as revealing key roles of conserved RNA molecules like let-7 in development. Words such as 'fundamental,' 'conserved,' and 'universal' highlight the perceived importance, though the conversations mostly focus on general interest rather than detailed critique or implications.

AgreementModerate agreement

Most discussions acknowledge the importance of the research, with some expressing appreciation for the foundational insights into evolutionarily conserved RNAs.

InterestHigh interest

Posts demonstrate high curiosity about the implications of let-7 RNA across species, indicating strong interest in developmental biology and evolutionary conservation.

EngagementNeutral engagement

While some comments reference specific findings and authors, many discussions remain surface-level, showing moderate engagement rather than deep technical analysis.

ImpactModerate impact

The discussions hint at the broad significance of these RNAs in developmental regulation, but few comments explicitly emphasize widespread scientific or medical impact.

Abstract in brief

  • The study discusses how two small RNA molecules, lin4 and let7, regulate key developmental stages in the nematode C. elegans, with lin4 acting during early larval stages and let7 during later stages.
  • let7 RNA is evolutionarily conserved and found in various animal species, including vertebrates and invertebrates, indicating its fundamental role in developmental timing, while lin4 is not detected outside nematodes.
  • The findings suggest that let7 RNAs may play a universal role across animals in controlling late-stage developmental transitions, given their conserved expression patterns at specific developmental stages across diverse species.]
Read the full abstract

Top posts

Most liked on X and Bluesky
叢雲くすり (創薬ちゃん)
@souyakuchan · X

主たる成果論文。いわゆる back-to-back 掲載というやつ。Cell 誌。 Cell, 75(5), pp. 843–854. Victor Ambros et al. https://t.co/PLw57884Cy Cell, 75(5), pp. 855–862. Gary Ruvkun et al. https://t.co/dJkXOApB2B Nature, 408(6808), pp. 86–89. Gary Ruvkun et al. https://t.co/j1B5DmNHad

Oct 7, 2024 · 8 likes · 3 shares · 10,232 followers View post →
Dr. Jason Begalke
@DrJasonBegalke · X

Reading: https://t.co/tbowvUZ2q6 https://t.co/0YxCCA7Wew https://t.co/AopRVKLysN #Medicine #STEAM #NLM #NIH

Oct 8, 2024 · 2,306 followers View post →
藪出毬
@M_Banba_ · X

RT @souyakuchan: 主たる成果論文。いわゆる back-to-back 掲載というやつ。Cell 誌。 Cell, 75(5), pp. 843–854. Victor Ambros et al. https://t.co/PLw57884Cy Cell, 75…

Oct 7, 2024 · 3 shares · 1,581 followers View post →
Shigeru Flower-Field
@shigeruflowerFi · X

RT @souyakuchan: 主たる成果論文。いわゆる back-to-back 掲載というやつ。Cell 誌。 Cell, 75(5), pp. 843–854. Victor Ambros et al. https://t.co/PLw57884Cy Cell, 75…

Oct 7, 2024 · 3 shares · 446 followers View post →

All mentions

Dr. Jason Begalke
@DrJasonBegalke · X

Reading: https://t.co/tbowvUZ2q6 https://t.co/0YxCCA7Wew https://t.co/AopRVKLysN #Medicine #STEAM #NLM #NIH

Oct 8, 2024 · 2,306 followers View post →
Shigeru Flower-Field
@shigeruflowerFi · X

RT @souyakuchan: 主たる成果論文。いわゆる back-to-back 掲載というやつ。Cell 誌。 Cell, 75(5), pp. 843–854. Victor Ambros et al. https://t.co/PLw57884Cy Cell, 75…

Oct 7, 2024 · 3 shares · 446 followers View post →
18
@howling18 · X

RT @souyakuchan: 主たる成果論文。いわゆる back-to-back 掲載というやつ。Cell 誌。 Cell, 75(5), pp. 843–854. Victor Ambros et al. https://t.co/PLw57884Cy Cell, 75…

Oct 7, 2024 · 3 shares · 230 followers View post →
藪出毬
@M_Banba_ · X

RT @souyakuchan: 主たる成果論文。いわゆる back-to-back 掲載というやつ。Cell 誌。 Cell, 75(5), pp. 843–854. Victor Ambros et al. https://t.co/PLw57884Cy Cell, 75…

Oct 7, 2024 · 3 shares · 1,581 followers View post →
叢雲くすり (創薬ちゃん)
@souyakuchan · X

主たる成果論文。いわゆる back-to-back 掲載というやつ。Cell 誌。 Cell, 75(5), pp. 843–854. Victor Ambros et al. https://t.co/PLw57884Cy Cell, 75(5), pp. 855–862. Gary Ruvkun et al. https://t.co/dJkXOApB2B Nature, 408(6808), pp. 86–89. Gary Ruvkun et al. https://t.co/j1B5DmNHad

Oct 7, 2024 · 8 likes · 3 shares · 10,232 followers View post →