Science February 2001 PMID 11181995

The sequence of the human genome.

J C Venter, M D Adams, E W Myers, P W Li, R J Mural, G G Sutton, H O Smith, M Yandell, C A Evans, R A Holt, J D Gocayne, P Amanatides, R M Ballew, D H Huson, J R Wortman

Mentions

154
Peak: 4 in Feb 2025
across 7 sources since Nov 2021

Extended reach

154,544
potential audience

Total likes

171

Video views

1,428

Mentions per month

Nov 2021 – Oct 2025

Where it's discussed

  • News68 articles
  • X / Twitter36 posts
  • Blogs36 articles
  • Facebook8 posts
  • Bluesky2 posts
  • YouTube2 videos
  • Reddit2 posts

AI synopsis

What people are saying

The overall tone reflects high engagement and interest in the scientific, historical, and social aspects of genome sequencing, with examples like mentions of Frederick Sanger’s contributions, debates over proprietary data, and the implications for understanding human diversity, all of which demonstrate that these discussions recognize the profound influence of the Human Genome Project on multiple facets of science and society.

AgreementModerate agreement

Most discussions acknowledge the importance and groundbreaking nature of the human genome sequencing, with some expressing admiration or support for the research, such as referencing its role in advancing medicine.

InterestHigh interest

The discussions demonstrate high curiosity about genetic sequencing, its history, and broader implications, indicating significant interest in the topic.

EngagementModerate engagement

Participants cite specific studies, historical figures, and technical aspects, which shows a moderate level of engagement and familiarity with the subject.

ImpactModerate impact

The conversations highlight the foundational impact of genome sequencing on science, medicine, and societal understanding, emphasizing its significance.

Abstract in brief

  • The human genome's euchromatic (gene-rich) regions were sequenced using the whole-genome shotgun method, resulting in a 3 billion base pair consensus sequence assembled from millions of high-quality reads, with efforts combining data from both Celera and public sources.
  • Two different assembly strategies produced similar results, covering over 90% of the genome in large scaffolds, and effectively reducing gaps, while public data was processed to minimize biases, leading to a more accurate representation of the genome.
  • The analysis identified around 26,588 confirmed protein-coding genes and about 12,000 additional computationally predicted ones, with a large portion of the genome being noncoding, including extensive intergenic regions and segmental duplications that highlight the genome's complex evolution.]

Top posts

Most liked on X and Bluesky
Prof. Nikolai Slavov
@slavov_n · X

Nature editorial making the case against genome sequencing: "As an information resource, the sequence of the human genome is an extremely doubtful asset ..." . https://t.co/x6TKLpbzzC

Feb 1, 2025 · 16 likes · 1 share · 21,631 followers View post →
SnO₂WMaN
@SnO2WMaN · X

ヒトゲノムの完全な解析の論文らしいが著者が多すぎる https://t.co/bYxz8ekEeg https://t.co/BlthliowQ2

Jun 15, 2024 · 16 likes · 1 share · 3,511 followers View post →
Gaurav Sharma, Ph.D.
@sharmaG30 · X

Today while @official_ibab MSc students were presenting these papers in my class, a question came into my mind, "Who would have reviewed these cult papers?" Most of the sequencing folks at that time would be involved in one of them. https://t.co/SG71o8Wiw5 https://t.co/PhP2ZuoDbz

Nov 22, 2021 · 7 likes · 3,436 followers View post →
Nikolai Slavov
@slavov-n.bsky.social · Bluesky

This Nature editorial argued against genome sequencing: "As an information resource, the sequence of the human genome is an extremely doubtful asset ..."

Feb 1, 2025 · 7 likes · 2 shares View post →
Héctor Candela
@candela_lab · X

#TalDiaComoHoy #OTD, 16 de febrero, se publicaban en 2001 los resultados de la secuenciación del genoma humano ("working draft") en la revista Science, un día después que en Nature. https://t.co/OYo2EqOhC4

Feb 16, 2022 · 6 likes · 3 shares · 1,524 followers View post →
(((Dan Graur))) ダン דן גראור
@DanGraur · X

The 2001 human genome article by @JCVenter should be retracted. The statement “DNA from 5 subjects was selected for sequencing: 2 males and 3 females—1 African-American, 1 Asian-Chinese, 1 Hispanic-Mexican, and 2 Caucasians" was a lie. @RetractionWatch https://t.co/c5DnnLkBjy

Apr 17, 2022 · 5 likes · 3,350 followers View post →

All mentions

non
@cassoseduk · X

@aliteyaah @Stephan80327996 @BC5515122765322 Bac+8 -> ingénieur civil à Genève (mon métier) + 2 licences en lettres et histoire + 1 doctorat en théologie Tout ca à 30 ans. Et toi Aletheia ? Rien. -> RSA ? Tu as lu "The sequence of the human genome." Science, 291(5507), 1304-1351 ? Lis. Ensuite on discutera entre adultes

Oct 17, 2025 · 7 followers View post →
Devorah Fune
@DevorahFun5508 · X

"The fact is that proprietary databases don't work for such basic and broadly needed information as the sequence of the human genome." – John Sulston https://t.co/bqAFyzEMuF

Oct 9, 2025 · 4 followers View post →
Luciana Knockaert
@LKnockaert87031 · X

The fact is that proprietary databases don't work for such basic and broadly needed information as the sequence of the human genome. – John Sulston

Sep 26, 2025 · 3 followers View post →
Mike Hirsh
@mph54.bsky.social · Bluesky

pbs.twimg.com/media/FaC1R6... Remembering the 1918 bday of British Chemist Frederick Sanger, one of only 5 people in history to receive 2 Nobel prizes- one for looking at the ultrastructure of the insulin molecule & the other for looking at the sequence of the human genome

Aug 13, 2025 View post →
(((Dan Graur))) ダン דן גראור
@DanGraur · X

15 years later, Science retracts ‘arsenic life’ paper. Interestingly, the 2001 human genome paper by Craig Venter et al. has not been retracted, despite containing mostly Public Consortium data and keeping its own data secret. https://t.co/c5DnnLkBjy https://t.co/Wk6GF5ZvvM

Jul 25, 2025 · 1 like · 3,350 followers View post →
Donating stolen car to NPR member station
@FoucaltFrenulum · X

@DouglasYaoDY We didn't know the sequence of the human genome 25 years ago. Current sequencing technology allows us to capture gene expression and chromatin accessibility in tens of thousands of single nuclei at the same time.

Mar 19, 2025 · 1 like · 119 followers View post →
Kyowon Jeong
@JeongKyowon · X

RT @slavov_n: Nature editorial making the case against genome sequencing: "As an information resource, the sequence of the human genome is…

Feb 1, 2025 · 1 share · 399 followers View post →
Nikolai Slavov
@slavov-n.bsky.social · Bluesky

This Nature editorial argued against genome sequencing: "As an information resource, the sequence of the human genome is an extremely doubtful asset ..."

Feb 1, 2025 · 7 likes · 2 shares View post →
Prof. Nikolai Slavov
@slavov_n · X

Nature editorial making the case against genome sequencing: "As an information resource, the sequence of the human genome is an extremely doubtful asset ..." . https://t.co/x6TKLpbzzC

Feb 1, 2025 · 16 likes · 1 share · 21,631 followers View post →
Dirk Lammerts - myNEXT
@myNEXT_Venture · X

Hey genomics data companies! DON'T try to become a drug development company. That did not work out for Celera despite having developed the most unique genomics dataset of its time - after all, Celera was the private company that first completed the sequence of the human genome in

Nov 13, 2024 · 1 like · 89 followers View post →
Make Lying Wrong Again
@LyingWrongAgain · X

@logistrix Good question. I am not a theist, but I might offer a few examples that could count as evidence, if demonstrated: - The efficacy of intercessory prayer - Precise and accurate prophesy - Ancient knowledge that can’t be accounted for (like the sequence of the human genome)

Aug 25, 2024 · 1 like · 2,582 followers View post →
Misha Teplitskiy | Science of Science
@MishaTeplitskiy · X

RT @timisstuck: Sunday philosophy read by me: An Object-oriented ontology approach to the human genome. From my truest love (the humanitie…

Jul 28, 2024 · 1 share · 8,880 followers View post →
timisstuck
@timisstuck · X

Sunday philosophy read by me: An Object-oriented ontology approach to the human genome. From my truest love (the humanities), I consider the birth and some features of a unique object: the sequence of the human genome. https://t.co/xziVvlsc2K

Jul 28, 2024 · 4 likes · 1 share · 1,544 followers View post →
Biongevity Inc
@Bgvity · X

RT @AnmolMD: In humans, genes vary in size from a few hundred DNA bases to more than 2 million bases. Human Genome Project determined the s…

Jul 3, 2024 · 11 shares · 1 followers View post →
Hytus
@Hytusx · X

RT @SnO2WMaN: ヒトゲノムの完全な解析の論文らしいが著者が多すぎる https://t.co/bYxz8ekEeg https://t.co/BlthliowQ2

Jun 15, 2024 · 1 share · 1,306 followers View post →
SnO₂WMaN
@SnO2WMaN · X

ヒトゲノムの完全な解析の論文らしいが著者が多すぎる https://t.co/bYxz8ekEeg https://t.co/BlthliowQ2

Jun 15, 2024 · 16 likes · 1 share · 3,511 followers View post →
Joseph
@AutumnalisVelum · X

@GatoRoj22857705 @Josefina_28 A qué especie pertenecen (ese cigoto, embrion, feto, etc)? Es un perro, es un gato o pertenece a la especie humana?

Apr 30, 2024 · 822 followers View post →
FRAUD ACCOUNT
@lisamparker71 · X

RT @lisamparker71: Krause & Trappe 6... one of Germany's biggest newspapers cleared its features section to print the sequence of the human…

Apr 14, 2024 · 2 shares · 9 followers View post →
VK Ulaganathan
@VK_Ulaganathan · X

The sequence of the human genome generated by the Human Genome Project (HGP) was not from a single person, rather a patchwork from multiple people. Can you guess from how many people's DNA was the human genome sequenced in the HGP?

Apr 8, 2024 · 940 followers View post →
FRAUD ACCOUNT
@lisamparker71 · X

RT @lisamparker71: Krause & Trappe 6... one of Germany's biggest newspapers cleared its features section to print the sequence of the human…

Mar 27, 2024 · 2 shares · 9 followers View post →
FRAUD ACCOUNT
@lisamparker71 · X

Krause & Trappe 6... one of Germany's biggest newspapers cleared its features section to print the sequence of the human genome... believing DNA would allow them to read human beings like a blueprint. https://t.co/MUPmc88jZZ

Mar 27, 2024 · 2 shares · 9 followers View post →
ACIDTA
@AcidtaBa · X

It wasn't until 2022 that mapping 100% was achieved. Knowing the sequence of the human genome allows for researching diseases, creating new drugs, and improving diagnosis.

Mar 12, 2024 · 209 followers View post →
Raelyn Serenity
@SerenityRaelyn · X

@jerecarrier4 @cafreeland , and the Guide RNA that can recognize the sequence DNA to be edited. So first the scientists need to identify the sequence of the human Genome that is causing the health problem Then they create a specific guide RNA to recognize that particular stretch of A's T's G's and C's

Feb 18, 2024 · 6 followers View post →
Enrique castrillo
@Enriquecas007 · X

@ForevrFree1776 Since the sequence of the human genome was completed and fully verified,it has been very very clear that there are ONE human race only.Therefore, there is no races among humans, there can not be racisms, ethnicities yes. Those that do not know or ignore this fact are ignorants !

Feb 12, 2024 · 88 followers View post →
mental
@sticky_tr · X

HGP (Human Genome Project) was an international effort to determine the sequence of the human genome and identify all the genes it contains. This project began in 1990 by James Watson, and it was a 15-year plan that had a 3B$ budget. Prior to this project, it was estimated + https://t.co/8uHAE2T7NE

Jan 6, 2024 · 1 like · 882 followers View post →
Michæl IHNC OLIDR, Buskerud's biscuit bearing bard
@Ulf_Othvegin · X

@HakunaMateria @Lauren_Beleaver @RedJohn50 @LondongirlSJ @bigtoekne Here is the sequence of the human genome. Perhaps you could find for me the genes that insist that England is the best place for warm beer and cold tea. https://t.co/MqBtsYNJ0F

Dec 18, 2023 · 395 followers View post →
Facts Interesting
@factresting · X

All humans share 99.9% of their DNA with one another. [Source: Venter et al., "The Sequence of the Human Genome," 2015] https://t.co/S3y2GVhOCg

Oct 28, 2023 · 7 followers View post →
Dr Danny Kingsley (she/her)
@dannykay68 · X

@DanGraur @ScienceMagazine Hi - can I get clarification of this please? When I open the paper https://t.co/kaoJKYom4p which is paywalled (so I can't open the full paper) the supplementary figures on that page appear to be available to me. Are you referring to other supplementary material?

Jun 20, 2023 · 3,530 followers View post →
La Science, CQFD
@ScienceCQFD · X

2001 > La séquence du génome humain https://t.co/0qfymDoYkE via @ScienceMagazine (en anglais) #ScienceCQFD

May 9, 2023 · 57,556 followers View post →
Héctor Candela
@candela_lab · X

RT @candela_lab: #TalDiaComoHoy #OTD, 16 de febrero, se publicaban en 2001 los resultados de la secuenciación del genoma humano ("working d…

Feb 15, 2023 · 3 shares · 1,524 followers View post →
Stefano Nichele
@stenichele · X

@pmddomingos https://t.co/N35EBCKAeA

Jan 24, 2023 · 1,923 followers View post →
د. عبدالمجيد الرفاعيAbdulmajeed Alrefaei
@DrAbdulmajeedFR · X

لاحظوا هنا عدد العلماء المشاركين ورقة #الجينوم_البشري عام ٢٠٠١ https://t.co/72uTJ9wI8B https://t.co/WRZpNYF8b1

Jan 5, 2023 · 1 like · 19,613 followers View post →
(((Dan Graur))) ダン דן גראור
@DanGraur · X

The 2001 human genome article by @JCVenter should be retracted. The statement “DNA from 5 subjects was selected for sequencing: 2 males and 3 females—1 African-American, 1 Asian-Chinese, 1 Hispanic-Mexican, and 2 Caucasians" was a lie. @RetractionWatch https://t.co/c5DnnLkBjy

Apr 17, 2022 · 5 likes · 3,350 followers View post →
Aurelio Gómez
@agomezcadenas · X

RT @candela_lab: #TalDiaComoHoy #OTD, 16 de febrero, se publicaban en 2001 los resultados de la secuenciación del genoma humano ("working d…

Feb 16, 2022 · 3 shares · 1,270 followers View post →
Instituto de Bioingeniería
@IB_UMH · X

RT @candela_lab: #TalDiaComoHoy #OTD, 16 de febrero, se publicaban en 2001 los resultados de la secuenciación del genoma humano ("working d…

Feb 16, 2022 · 3 shares · 956 followers View post →
Héctor Candela
@candela_lab · X

#TalDiaComoHoy #OTD, 16 de febrero, se publicaban en 2001 los resultados de la secuenciación del genoma humano ("working draft") en la revista Science, un día después que en Nature. https://t.co/OYo2EqOhC4

Feb 16, 2022 · 6 likes · 3 shares · 1,524 followers View post →
Pepe Jiménez Heffernan
@pepeheffernan · X

@shoba82 Lander ES et al. Initial sequencing and analysis of the human genome. Nature. 2001 Feb 15;409(6822):860-921. doi: 10.1038/35057062. Venter JC et al. The sequence of the human genome. Science. 2001 Feb 16;291(5507):1304-51. doi: 10.1126/science.1058040.

Nov 28, 2021 · 11,559 followers View post →
Gaurav Sharma, Ph.D.
@sharmaG30 · X

Today while @official_ibab MSc students were presenting these papers in my class, a question came into my mind, "Who would have reviewed these cult papers?" Most of the sequencing folks at that time would be involved in one of them. https://t.co/SG71o8Wiw5 https://t.co/PhP2ZuoDbz

Nov 22, 2021 · 7 likes · 3,436 followers View post →