Topical L-ascorbic acid: percutaneous absorption studies.

Abstract in brief

• The study focuses on how Lascorbic acid (Vitamin C) can be effectively absorbed through the skin to boost its natural antioxidant defenses, which protect against damage from ultraviolet light.
• It shows that for optimal skin absorption, Lascorbic acid must be formulated at a pH below 3.5, with saturated skin levels reached after three daily applications, and a tissue half-life of about four days.
• The effectiveness of skin absorption depends heavily on formulation, and different derivatives of Lascorbic acid do not improve skin levels compared to pure Lascorbic acid.]