J R Soc Med May 2002 PMID 11983761

The hypocretin/orexin system.

I O Ebrahim, R S Howard, M D Kopelman, M K Sharief, A J Williams

Mentions

33
Peak: 3 in Nov 2021
across 5 sources since Mar 2020

Extended reach

50,296
potential audience

Total likes

50

Video views

1,278

Mentions per month

Mar 2020 – Apr 2025

Where it's discussed

  • X / Twitter12 posts
  • News10 articles
  • Blogs6 articles
  • Facebook3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions highlight the importance of the hypocretin/orexin system in sleep and neurological functions, with mentions of new research perspectives, animal models, and potential therapies. The tone ranges from technical references to praise for engaging lectures, illustrating a mix of scientific curiosity and recognition of its research significance.

AgreementModerate agreement

Most discussions recognize the significance of the hypocretin/orexin system, especially in sleep regulation and narcolepsy research, showing general support for the publication’s importance.

InterestHigh interest

Participants demonstrate high interest by engaging with multiple aspects such as animal models, neural circuitry, and new perspectives, indicating a keen curiosity.

EngagementHigh engagement

Many posts go beyond surface mentions, referencing specific research contexts, biological examples, and expressing admiration, reflecting deep engagement.

ImpactModerate impact

The discussions suggest that understanding this system could influence future research directions and treatments, though explicit claims of revolutionary impact are moderate.

Abstract in brief

  • The hypocretinorexin system is a network of neurons in the brain that produce chemicals called hypocretins or orexins, which play a key role in regulating sleep, wakefulness, and arousal.
  • This system is linked to conditions like narcolepsy, where the production of hypocretins is reduced, leading to excessive daytime sleepiness and disrupted sleep patterns.
  • Research on this system helps us understand how the brain controls alertness and how disturbances can lead to sleep disorders, potentially guiding new treatments.

Top posts

Most liked on X and Bluesky
Daniel J Drucker
@DanielJDrucker · X

New perspectives on the hypocretin orexin system Drs. Gao & Tamas Horvath @YaleMed @Yale #Endocrinereviews https://t.co/MfSrNNFaLO https://t.co/LY3snqCkcv

Nov 19, 2021 · 9 likes · 2 shares · 34,928 followers View post →
Christine Faunce
@clfaunce · X

@Neuro_musings @VTNeuro I’m jealous that future VT Neuro students will have you as a professor! Your lecture on the hypocretin/orexin system was SO engaging! Congratulations and go Hokies!!

Jul 5, 2021 · 2 likes · 498 followers View post →
Sleep Research
@SleepResearch_ · X

Animal Models of Narcolepsy and the Hypocretin/Orexin System: Past, Present, and Future. https://t.co/XwfknqdSNp

Dec 15, 2020 · 7,237 followers View post →
CarlosAguilarSalinas
@caguilarsalinas · X

RT @DanielJDrucker: New perspectives on the hypocretin orexin system Drs. Gao & Tamas Horvath @YaleMed @Yale #Endocrinereviews https://t.co…

Nov 19, 2021 · 2 shares · 1,636 followers View post →
Zebrafish Dev. Neurobiology Group
@ZebrafishGroup · X

"Here, we show that the South Asian fish species Chromobotia macracanthus exhibits a sleep-like state during which individuals stop swimming and rest on their side. Strikingly, we discovered that the Hypocretin/Orexin system is pseudogenized in C. macracanthus.." https://t.co/erglspjBUK

Mar 14, 2024 · 1,015 followers View post →
Prof Marios Adamou OBE
@DrMariosAdamou · X

Alertness and feeding behaviors in ADHD: does the hypocretin/orexin system play a role? - PubMed https://t.co/RFYuTw9S56

Apr 12, 2025 · 1,012 followers View post →

All mentions

Prof Marios Adamou OBE
@DrMariosAdamou · X

Alertness and feeding behaviors in ADHD: does the hypocretin/orexin system play a role? - PubMed https://t.co/RFYuTw9S56

Apr 12, 2025 · 1,012 followers View post →
Prof Marios Adamou OBE
@DrMariosAdamou · X

Alertness and feeding behaviors in ADHD: does the hypocretin/orexin system play a role? - PubMed https://t.co/RFYuTw9S56

Apr 12, 2025 · 1,012 followers View post →
Zebrafish Dev. Neurobiology Group
@ZebrafishGroup · X

"Here, we show that the South Asian fish species Chromobotia macracanthus exhibits a sleep-like state during which individuals stop swimming and rest on their side. Strikingly, we discovered that the Hypocretin/Orexin system is pseudogenized in C. macracanthus.." https://t.co/erglspjBUK

Mar 14, 2024 · 1,015 followers View post →
P
@psychopharmacol · X

the endocannabinoid system, the hypocretin/orexin system, and apoptosis. (2/2)

Jan 18, 2024 · 569 followers View post →
Elisa Haas, MD
@ElisaAHaas · X

RT @DanielJDrucker: New perspectives on the hypocretin orexin system Drs. Gao & Tamas Horvath @YaleMed @Yale #Endocrinereviews https://t.co…

Nov 21, 2021 · 2 shares · 452 followers View post →
CarlosAguilarSalinas
@caguilarsalinas · X

RT @DanielJDrucker: New perspectives on the hypocretin orexin system Drs. Gao & Tamas Horvath @YaleMed @Yale #Endocrinereviews https://t.co…

Nov 19, 2021 · 2 shares · 1,636 followers View post →
Daniel J Drucker
@DanielJDrucker · X

New perspectives on the hypocretin orexin system Drs. Gao & Tamas Horvath @YaleMed @Yale #Endocrinereviews https://t.co/MfSrNNFaLO https://t.co/LY3snqCkcv

Nov 19, 2021 · 9 likes · 2 shares · 34,928 followers View post →
Christine Faunce
@clfaunce · X

@Neuro_musings @VTNeuro I’m jealous that future VT Neuro students will have you as a professor! Your lecture on the hypocretin/orexin system was SO engaging! Congratulations and go Hokies!!

Jul 5, 2021 · 2 likes · 498 followers View post →
Anaclet Lab
@anaclet_lab · X

Animal models of narcolepsy and the hypocretin/orexin system: Past, present, and future https://t.co/fwqaBaURcb

Jun 15, 2021 · 274 followers View post →
Sleep Research
@SleepResearch_ · X

Animal Models of Narcolepsy and the Hypocretin/Orexin System: Past, Present, and Future. https://t.co/XwfknqdSNp

Dec 15, 2020 · 7,237 followers View post →
DogBot
@Dog_paper_bot · X

New dog paper! Animal Models of Narcolepsy and the Hypocretin/Orexin System: Past, Present, and Future. https://t.co/g4O8634HlP

Dec 15, 2020 · 69 followers View post →
single cell papers
@sc_papers · X

The hypocretin (orexin) system: from a neural circuitry perspective. https://t.co/8ZkaxxgD7a

Mar 6, 2020 · 304 followers View post →