High bone density due to a mutation in LDL-receptor-related protein 5.

Lynn M Boyden, Junhao Mao, Joseph Belsky, Lyle Mitzner, Anita Farhi, Mary A Mitnick, Dianqing Wu, Karl Insogna, Richard P Lifton

May 2002 N Engl J Med

Synopsis of Social media discussions

Discussions include references to the mutation G171V in the LRP5 gene and examples of individuals with strong bones, exemplified by posts highlighting 'nearly unbreakable bones' and connections to superpower-like characteristics. Words like 'questioning' and mentions of source citations reflect a cautious tone, showing curiosity but also skepticism about the research validity and implications.

A
Agreement
 Neither agree nor disagree

The discussions neither strongly support nor oppose the findings, with some skepticism evident in comments questioning source citation details.

I
Interest
 Moderate level of interest

Participants show a moderate interest, especially in how mutations relate to traits like bone strength and superpowers, indicating curiosity but not deep technical engagement.

E
Engagement
 Moderate level of engagement

The posts include references to specific studies and raise questions about scientific validity, suggesting a moderate level of thoughtful engagement.

I
Impact
 Neutral impact

The overall discussions are informal and based on limited shares of information, meaning they don't imply significant societal impact yet.

Social Mentions

YouTube

3 Videos

Facebook

6 Posts

Twitter

7 Posts

Blogs

3 Articles

News

6 Articles

Reddit

2 Posts

Metrics

Video Views

1,376,300

Total Likes

26,578

Extended Reach

1,391,373

Social Features

27

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Genetic Mutations and Superhuman Traits Explained

Genetic Mutations and Superhuman Traits Explained

SciShow

May 22, 2017

1,356,773 views

Genetic Mutation in LRP5 Enhances Bone Density and Promotes Superpoderes

Genetic Mutation in LRP5 Enhances Bone Density and Promotes Superpoderes

Instante Biotec

August 23, 2017

9,903 views

Exploring the Impact of LRP5 Mutations on Bone Density and Wnt Signaling

Exploring the Impact of LRP5 Mutations on Bone Density and Wnt Signaling

This study identifies a mutation in the LRP5 gene (V171) that causes high bone density by increasing Wnt signaling. It disrupts the inhibition by Dkk1, leading to excessive bone formation. These findings suggest targeting the Wnt pathway may offer osteoporosis treatments.

Jackson Wheat

February 12, 2018

9,624 views

  • Liberty and Laughs
    @FreeWitWins (Twitter)

    RT @GardenerContext: @MrBallen LRP5 (Strong Bones): Mutation: G171V Effect: Increased bone density, leading to exceptionally strong bones.…
    view full post

    June 4, 2024

    1

  • Liberty and Laughs
    @FreeWitWins (Twitter)

    @MrBallen LRP5 (Strong Bones): Mutation: G171V Effect: Increased bone density, leading to exceptionally strong bones. Example: A Connecticut family with nearly unbreakable bones. Study: Boyden LM, et al. (2002). "High bone density due to a mutation in LDL-receptor-related protein 5." NEJM.
    view full post

    June 4, 2024

    1

  • John Smith⚛ (Explorer of Reality)
    @doofgeek4011 (Twitter)

    RT @JacksonWheat1: @RJDownard @sheaSwatson @TakeThatDarwin https://t.co/2MwhLES4jM
    view full post

    October 1, 2022

    2

  • Rulon James Downard
    @RJDownard (Twitter)

    @NelsonMKerr @sheaSwatson @TakeThatDarwin So it's been an hour since Shea posted this, and nothing from him on the question of whether he'd ever fact checked its slim source citations (all general works btw, contrasting with the lengthy technical lit in @JacksonWheat1's 2018 commentary https://t.co/9gFqC4bxQR)
    view full post

    October 1, 2022

    1

  • Rulon James Downard
    @RJDownard (Twitter)

    RT @JacksonWheat1: @RJDownard @sheaSwatson @TakeThatDarwin https://t.co/2MwhLES4jM
    view full post

    October 1, 2022

    2

  • Jackson Wheat
    @JacksonWheat1 (Twitter)

    @RJDownard @sheaSwatson @TakeThatDarwin https://t.co/2MwhLES4jM
    view full post

    October 1, 2022

    6

    2

  • Instante Biotec
    @InstanteBiotec (Twitter)

    Você sabia que algumas mutações podem te dar características semelhantes a super-poderes?
    view full post

    March 14, 2019

Abstract Synopsis

  • The study identifies a mutation in the LRP5 gene (specifically LRP5V171) that causes high bone density and related features like a thick mandible and torus palatinus, by increasing Wnt signaling.
  • The mutation disrupts the normal inhibition of Wnt signaling by Dkk1, leading to unregulated Wnt activity, which promotes excessive bone formation.
  • These findings highlight how changes in LRP5 affect bone mass and suggest that targeting the Wnt pathway, especially Dkk1, could be a strategy for treating or preventing osteoporosis.]