PubHawk
N Engl J Med May 2002 PMID 12015390

High bone density due to a mutation in LDL-receptor-related protein 5.

Lynn M Boyden, Junhao Mao, Joseph Belsky, Lyle Mitzner, Anita Farhi, Mary A Mitnick, Dianqing Wu, Karl Insogna, Richard P Lifton

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Mentions

27
Peak: 4 in Oct 2022
across 6 sources since May 2017

Extended reach

1,391,373
potential audience

Total likes

26,578

Video views

1,376,300

Mentions per month

May 2017 – Jun 2024

Where it's discussed

  • X / Twitter7 posts
  • Facebook6 posts
  • News6 articles
  • YouTube3 videos
  • Blogs3 articles
  • Reddit2 posts

AI synopsis

What people are saying

Discussions include references to the mutation G171V in the LRP5 gene and examples of individuals with strong bones, exemplified by posts highlighting 'nearly unbreakable bones' and connections to superpower-like characteristics. Words like 'questioning' and mentions of source citations reflect a cautious tone, showing curiosity but also skepticism about the research validity and implications.

AgreementNeither agree nor disagree

The discussions neither strongly support nor oppose the findings, with some skepticism evident in comments questioning source citation details.

InterestModerate interest

Participants show a moderate interest, especially in how mutations relate to traits like bone strength and superpowers, indicating curiosity but not deep technical engagement.

EngagementModerate engagement

The posts include references to specific studies and raise questions about scientific validity, suggesting a moderate level of thoughtful engagement.

ImpactNeutral impact

The overall discussions are informal and based on limited shares of information, meaning they don't imply significant societal impact yet.

Abstract in brief

  • The study identifies a mutation in the LRP5 gene (specifically LRP5V171) that causes high bone density and related features like a thick mandible and torus palatinus, by increasing Wnt signaling.
  • The mutation disrupts the normal inhibition of Wnt signaling by Dkk1, leading to unregulated Wnt activity, which promotes excessive bone formation.
  • These findings highlight how changes in LRP5 affect bone mass and suggest that targeting the Wnt pathway, especially Dkk1, could be a strategy for treating or preventing osteoporosis.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Jackson Wheat
@JacksonWheat1 · X

@RJDownard @sheaSwatson @TakeThatDarwin https://t.co/2MwhLES4jM

Oct 1, 2022 · 6 likes · 2 shares · 2,852 followers View post →
Rulon James Downard
@RJDownard · X

@NelsonMKerr @sheaSwatson @TakeThatDarwin So it's been an hour since Shea posted this, and nothing from him on the question of whether he'd ever fact checked its slim source citations (all general works btw, contrasting with the lengthy technical lit in @JacksonWheat1's 2018 commentary https://t.co/9gFqC4bxQR)

Oct 1, 2022 · 1 like · 3,579 followers View post →
John Smith⚛ (Explorer of Reality)
@doofgeek4011 · X

RT @JacksonWheat1: @RJDownard @sheaSwatson @TakeThatDarwin https://t.co/2MwhLES4jM

Oct 1, 2022 · 2 shares · 4,035 followers View post →
Rulon James Downard
@RJDownard · X

RT @JacksonWheat1: @RJDownard @sheaSwatson @TakeThatDarwin https://t.co/2MwhLES4jM

Oct 1, 2022 · 2 shares · 3,579 followers View post →
Instante Biotec
@InstanteBiotec · X

Você sabia que algumas mutações podem te dar características semelhantes a super-poderes?

Mar 14, 2019 · 631 followers View post →
Liberty and Laughs
@FreeWitWins · X

RT @GardenerContext: @MrBallen LRP5 (Strong Bones): Mutation: G171V Effect: Increased bone density, leading to exceptionally strong bones.…

Jun 4, 2024 · 1 share · 191 followers View post →

All mentions

Liberty and Laughs
@FreeWitWins · X

RT @GardenerContext: @MrBallen LRP5 (Strong Bones): Mutation: G171V Effect: Increased bone density, leading to exceptionally strong bones.…

Jun 4, 2024 · 1 share · 191 followers View post →
Liberty and Laughs
@FreeWitWins · X

@MrBallen LRP5 (Strong Bones): Mutation: G171V Effect: Increased bone density, leading to exceptionally strong bones. Example: A Connecticut family with nearly unbreakable bones. Study: Boyden LM, et al. (2002). "High bone density due to a mutation in LDL-receptor-related protein 5." NEJM.

Jun 4, 2024 · 1 share · 191 followers View post →
John Smith⚛ (Explorer of Reality)
@doofgeek4011 · X

RT @JacksonWheat1: @RJDownard @sheaSwatson @TakeThatDarwin https://t.co/2MwhLES4jM

Oct 1, 2022 · 2 shares · 4,035 followers View post →
Rulon James Downard
@RJDownard · X

@NelsonMKerr @sheaSwatson @TakeThatDarwin So it's been an hour since Shea posted this, and nothing from him on the question of whether he'd ever fact checked its slim source citations (all general works btw, contrasting with the lengthy technical lit in @JacksonWheat1's 2018 commentary https://t.co/9gFqC4bxQR)

Oct 1, 2022 · 1 like · 3,579 followers View post →
Rulon James Downard
@RJDownard · X

RT @JacksonWheat1: @RJDownard @sheaSwatson @TakeThatDarwin https://t.co/2MwhLES4jM

Oct 1, 2022 · 2 shares · 3,579 followers View post →
Jackson Wheat
@JacksonWheat1 · X

@RJDownard @sheaSwatson @TakeThatDarwin https://t.co/2MwhLES4jM

Oct 1, 2022 · 6 likes · 2 shares · 2,852 followers View post →
Instante Biotec
@InstanteBiotec · X

Você sabia que algumas mutações podem te dar características semelhantes a super-poderes?

Mar 14, 2019 · 631 followers View post →