May 2002 PMID 12015394

Disputed maternity leading to identification of tetragametic chimerism.

Neng Yu, Margot S Kruskall, Juan J Yunis, Joan H M Knoll, Lynne Uhl, Sharon Alosco, Marina Ohashi, Olga Clavijo, Zaheed Husain, Emilio J Yunis, Jorge J Yunis, Edmond J Yunis

Mentions

74
Peak: 8 in Feb 2020
across 7 sources since Sep 2015

Extended reach

234,062
potential audience

Total likes

89

Video views

3,360

Mentions per month

Sep 2015 – Nov 2025

Where it's discussed

  • X / Twitter32 posts
  • Reddit11 posts
  • News11 articles
  • Facebook10 posts
  • Instagram6 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The group demonstrates strong interest through references to case studies and mentions of well-known medical journals, such as the New England Journal of Medicine, emphasizing the relevance of the research. The tone is analytical and inquisitive, with specific examples like discussions on DNA's role in organismality and references to complex biological cases, which underscore the perceived importance and potential impact of the publication.

AgreementModerate agreement

Most discussions acknowledge the significance of tetragametic chimerism and its medical implications, showing general support for the publication's findings.

InterestHigh interest

The majority express a high level of curiosity and fascination with the case, highlighting the intriguing nature of genetic anomalies.

EngagementModerate engagement

Several contributions involve detailed explanations, references to specific studies, and debates about the biological implications, indicating active involvement.

ImpactModerate impact

The discussions reflect an awareness that this research influences understanding of genetics and familial relationships, though the overall discourse remains within academic and medical interest levels.

Abstract in brief

  • The text discusses a case where confusing or disputed maternity results in the discovery of tetragametic chimerism, a rare condition where an individual is made up of two different sets of DNA due to the fusion of two fertilized eggs.
  • It highlights how this genetic anomaly can complicate paternity and maternity tests, as standard testing might incorrectly identify biological relationships.
  • The identification of tetragametic chimerism in this case underscores the importance of advanced genetic analysis in resolving complex medical and familial issues.]

Top posts

Most liked on X and Bluesky
Fadel Alrowaie
@fadelrowaie · X

#افحصو_طلال_2 تعرف هذه الحالة علميا Tetragametic Chimerism وهذه الحالة نشرت عام ٢٠٠٢ بمجلة نيوانجلاند الطبية العريقة https://t.co/EN1h5U8Gb7

Feb 27, 2020 · 20 likes · 7 shares · 25,238 followers View post →
Shining Science
@ShiningScience · X

Reference | Source: Disputed maternity leading to identification of tetragametic chimerism https://t.co/9U0c16AoKy

Nov 23, 2025 · 12 likes · 1 share · 86,162 followers View post →
Cuando la duda se acepta como ignorancia.
@ErFotingo · X

2 óvulos fecundados por dos espermatozoides coincidieron en un útero y, en vez de dar lugar a 2 hermanas, se fusionaron para formar una sola persona: ¿ La identidad del ser humano NO está en su #ADN ?

May 9, 2024 · 3 likes · 2 shares · 803 followers View post →
George Harvey
@DrGeorgeHarvey · X

@SusannaLHarris Two non-identical embryos (technically gamates) can fuse in the womb to create one human that has two distinct sets of DNA. Often whole organs can be from one set only. This is called Tetragametic Chimerism. In one case it caused a disputed maternity https://t.co/Q5qBuV1rpd

Aug 18, 2020 · 3 likes · 1 share · 180 followers View post →
Carlos
@carlosbiologia1 · X

Disputed Maternity Leading to Identification of Tetragametic Chimerism | New England Journal of Medicine https://t.co/qZOds8q5rk

May 8, 2024 · 2 likes · 190 followers View post →
c0nc0rdance
@c0nc0rdance · X

@KingCrocoduck @updatewithinfo @GEdwardsTwit https://t.co/aDbPooOUoK

Mar 23, 2019 · 1 like · 9,821 followers View post →

All mentions

BreakthroughMedicine&AdvancedResearchTools
@JayChance12 · X

RT @ShiningScience: Reference | Source: Disputed maternity leading to identification of tetragametic chimerism https://t.co/9U0c16AoKy

Nov 23, 2025 · 1 share · 645 followers View post →
Shining Science
@ShiningScience · X

Reference | Source: Disputed maternity leading to identification of tetragametic chimerism https://t.co/9U0c16AoKy

Nov 23, 2025 · 12 likes · 1 share · 86,162 followers View post →
technolib8080
@techliberty2222 · X

@streamkamala @Www3Linux @Tomoejp1236 @streamkamala 大学教授よりも貴方のほうが正しいとお主張されるの?そもそも「実際に生殖可能な両方の配偶子」なんて教授のコメントに書いていませんよ。教授のコメントはtetragametic chimerism(四親キメラ)と呼ばれる事例の話では? https://t.co/t0OuoFHgXw

Sep 30, 2025 · 111 followers View post →
Rohan
@Rohanburdened · X

@TerfHappy @delilahmused @PMaxiums @zaelefty Do you dispute anything important on that wikipedia page? Her case is kinda famous https://t.co/3Xh4qsvr1Z Given the date and details I think this is the study on Lydia, but they dont mention her name https://t.co/T08eMI4PPP https://t.co/piBQkU3OLW

May 25, 2025 · 548 followers View post →
✞ GOD IS GOOD
@Godisgood1836 · X

@dcs_vortex @NotFarLeftAtAll Yu, N., et al. (2006). "Disputed Maternity Leading to Identification of Tetragametic Chimerism." New England Journal of Medicine, 346(20), 1545–1552. DOI: 10.1056/NEJMoa013452.

May 19, 2025 · 1,201 followers View post →
MissAnthrope
@LyssAnthrope · X

@JoseLuisSdelRio @Patrick66536255 @theladykatie All that saying is that a zygote may eventually become an organism not that they are one in the zygote stage Surely you know that DNA alone does not define organismality Ex Chimerism https://t.co/j08k2qMen9 https://t.co/zvKIKd9vh6 https://t.co/vQkF4KABHW https://t.co/Ywqx3G3xC2

Nov 13, 2024 · 1,239 followers View post →
billrobo
@billrobo · X

Disputed Maternity Leading to Identification of Tetragametic Chimerism | New England Journal of Medicine https://t.co/amdvtLYb0X

May 11, 2024 · 511 followers View post →
Olga Degayón Roldán
@OlgaDegayon · X

RT @ErFotingo: 2 óvulos fecundados por dos espermatozoides coincidieron en un útero y, en vez de dar lugar a 2 hermanas, se fusionaron para…

May 9, 2024 · 2 shares · 2,781 followers View post →
Miren Gurutxe
@Gurutxe1 · X

RT @ErFotingo: 2 óvulos fecundados por dos espermatozoides coincidieron en un útero y, en vez de dar lugar a 2 hermanas, se fusionaron para…

May 9, 2024 · 2 shares · 48,061 followers View post →
Cuando la duda se acepta como ignorancia.
@ErFotingo · X

2 óvulos fecundados por dos espermatozoides coincidieron en un útero y, en vez de dar lugar a 2 hermanas, se fusionaron para formar una sola persona: ¿ La identidad del ser humano NO está en su #ADN ?

May 9, 2024 · 3 likes · 2 shares · 803 followers View post →
Carlos
@carlosbiologia1 · X

Disputed Maternity Leading to Identification of Tetragametic Chimerism | New England Journal of Medicine https://t.co/qZOds8q5rk

May 8, 2024 · 2 likes · 190 followers View post →
SALMO RASKIN
@RaskinSalmo · X

Aqui vai um dos primeiros artigos mostrando um caso de quimerismo materno que levou a exclusão da maternidade biológica . NEJM 2002 https://t.co/9mLBtCkxhi

May 7, 2023 · 1 like · 4,505 followers View post →
Pegasos
@Pegasos1891 · X

@AnneTorppa @ranzku @Yrtithepreaa https://t.co/W2YtSNJiIR

Dec 9, 2022 · 21 followers View post →
MJones
@Kiwipally · X

@SwipeWright Ah, mosaics. Sadly, they will remain childless as well, because clearly this woman only thought she had been pregnant and given birth: https://t.co/aVILX6qc13

Jul 15, 2022 · 1,393 followers View post →
uuepa
@xuuepa · X

@SuperBoyacense @juda712 @CareRaroHp @SebBenj97 pero más importante porque atribuye el quimerísmo a un gemelo... los gemelos comparten el mismo código genético. Entonces busqué el artículo citado https://t.co/Iyc1Im4qeS Pues resulta que en este caso particular, el quimerismo hace que se generen 4 tipos de gametos.

Feb 13, 2022 · 1 like · 52 followers View post →
Makena Onjerika
@Onjerika · X

@savvykenya Apparently not. This has happened to women before: https://t.co/ivWkNqWyvj

Jul 18, 2021 · 1 like · 4,987 followers View post →
JoJaSciPo
@strangetruther · X

RT @DrGeorgeHarvey: @SusannaLHarris Two non-identical embryos (technically gamates) can fuse in the womb to create one human that has two d…

Aug 18, 2020 · 1 share · 5,065 followers View post →
George Harvey
@DrGeorgeHarvey · X

@SusannaLHarris Two non-identical embryos (technically gamates) can fuse in the womb to create one human that has two distinct sets of DNA. Often whole organs can be from one set only. This is called Tetragametic Chimerism. In one case it caused a disputed maternity https://t.co/Q5qBuV1rpd

Aug 18, 2020 · 3 likes · 1 share · 180 followers View post →
Embryology
@Embryology_ · X

Chimera هو حيوان يتكون من أربع خلايا أبوية ( بيضتين مخصبتين أو أجنة مبكرة تلتحم وتتحد معا). يحتفظ كل تجمع من الخلايا بصفته الخاصة ويكون الحيوان الناتج خليطا من الأنسجة. وغالبا ما يشاهد في الحيوان ونادرا في الإنسان المرجع: https://t.co/rLgis5jQ00

Mar 8, 2020 · 1 like · 58 followers View post →
not me
@Aljazita · X

RT @fadelrowaie: #افحصو_طلال_2 تعرف هذه الحالة علميا Tetragametic Chimerism وهذه الحالة نشرت عام ٢٠٠٢ بمجلة نيوانجلاند الطبية العريقة http…

Feb 28, 2020 · 7 shares · 14,928 followers View post →
Mostapha Habib Allah
@NephroMostapha · X

RT @fadelrowaie: #افحصو_طلال_2 تعرف هذه الحالة علميا Tetragametic Chimerism وهذه الحالة نشرت عام ٢٠٠٢ بمجلة نيوانجلاند الطبية العريقة http…

Feb 28, 2020 · 7 shares · 1,537 followers View post →
Amani Azizalrahman
@who_else19 · X

RT @fadelrowaie: #افحصو_طلال_2 تعرف هذه الحالة علميا Tetragametic Chimerism وهذه الحالة نشرت عام ٢٠٠٢ بمجلة نيوانجلاند الطبية العريقة http…

Feb 27, 2020 · 7 shares · 6,046 followers View post →
alhariri
@azoz4330 · X

RT @fadelrowaie: #افحصو_طلال_2 تعرف هذه الحالة علميا Tetragametic Chimerism وهذه الحالة نشرت عام ٢٠٠٢ بمجلة نيوانجلاند الطبية العريقة http…

Feb 27, 2020 · 7 shares · 116 followers View post →
ريم
@REEMI54195570 · X

RT @fadelrowaie: #افحصو_طلال_2 تعرف هذه الحالة علميا Tetragametic Chimerism وهذه الحالة نشرت عام ٢٠٠٢ بمجلة نيوانجلاند الطبية العريقة http…

Feb 27, 2020 · 7 shares · 200 followers View post →
Fadel Alrowaie
@fadelrowaie · X

#افحصو_طلال_2 تعرف هذه الحالة علميا Tetragametic Chimerism وهذه الحالة نشرت عام ٢٠٠٢ بمجلة نيوانجلاند الطبية العريقة https://t.co/EN1h5U8Gb7

Feb 27, 2020 · 20 likes · 7 shares · 25,238 followers View post →
Ajay Kher
@ajaynephro · X

found the reference:https://t.co/PJMf0UXWqT https://t.co/x6lZVDm8Cg

Feb 21, 2020 · 582 followers View post →
matsukura masaki
@_M31_ · X

RT @loquat_priest: 細胞レベルのキメラじゃなくてDNAレベルのキメラだったのか。WikipediaからリンクのあるDNAキメラについての報告はこれ。 NEJM 346: 1545–1552. PMID 12015394 https://t.co/W8XYose…

Feb 12, 2020 · 1 share · 2,977 followers View post →
Angsuman Chakraborty ✪
@angsuman · X

Disputed Maternity Leading to Identification of Tetragametic Chimerism https://t.co/IoedqoBm1Q

Nov 30, 2019 · 7,509 followers View post →
#lili (they/elle)
@heybouncer · X

RT @balkraix: Esto efecticamente esta respaldado por un paper en el “New England Journal of Medicine “ de un case reporta de una mujer http…

Aug 20, 2019 · 3 shares · 1,594 followers View post →
Génesis
@geneglez · X

RT @balkraix: Esto efecticamente esta respaldado por un paper en el “New England Journal of Medicine “ de un case reporta de una mujer http…

Aug 20, 2019 · 3 shares · 861 followers View post →
Pamela P RocknRollNurse
@RocknRollNurse1 · X

Disputed Maternity Leading to Identification of Tetragametic Chimerism | NEJM https://t.co/Hsr7q7qmPz

Aug 6, 2019 · 263 followers View post →
c0nc0rdance
@c0nc0rdance · X

@KingCrocoduck @updatewithinfo @GEdwardsTwit https://t.co/aDbPooOUoK

Mar 23, 2019 · 1 like · 9,821 followers View post →
Tudo Sobre Quimera | PDF | Reproduction | Life Sciences
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identification of tetragametic chimerism". N Engl J Med. 346 (20): 1545–52. doi:10.1056/NEJMoa013452. PMID 12015394. Appel, Jacob M. " ...

Dec 16, 2025 View →
KİMERİZM | PDF | Twin | Reproduction
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... 10.1056/nejmoa013452 • https://abcnews.go.com/Primetime/shes-twin/story?id=2315693 • https://link.springer.com/article/10.1007/s10815-017-1064-6 • https ...

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... 10.1056/NEJMoa013452. Gilgenkrantz S. Nouveaux regards sur les mosaïques et chimères humaines. Med Sci (Paris). 2002 Oct;18(10):925-2. doi: 10.1051/medsci ...

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Dec 16, 2025 View →
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... 10.1056/NEJMoa013452. Gilgenkrantz S. Nouveaux regards sur les mosaïques et chimères humaines. Med Sci (Paris). 2002 Oct;18(10):925-2. doi: 10.1051/medsci ...

Dec 16, 2025 View →
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... 10.1056/NEJMoa013452. Gilgenkrantz S. Nouveaux regards sur les mosaïques et chimères humaines. Med Sci (Paris). 2002 Oct;18(10):925-2. doi: 10.1051/medsci ...

Dec 16, 2025 View →
Señales físicas: Pueden tener ojos de colores diferentes ...
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... 10.1056/NEJMoa013452 ​Artículos de revisión sobre "Human Chimerism" en revistas de genética como Nature Reviews Genetics o el American ...

Oct 6, 2025 View →
Loïc-DUCHAMP - Facebook
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org/doi/full/10.1056/NEJMoa013452 2. Cas de Lydia Fairchild (USA, 2002-2004) Tests ADN négatifs lors d'un contrôle judiciaire — elle ...

Aug 20, 2025 View →
Иннервация языка и окружающих фасциальных структур https ...
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doi: 10.1056/NEJMoa013452 2. Forsberg, L. A., Gisselsson, D., Strömbeck, B., Sterner, M., & Ståhl, F. (2023). Paternal discrepancy due to ...

May 21, 2025 View →
Отвечаю: Карел Левит утверждал, что «правильное дыхание ...
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doi: 10.1056/NEJMoa013452 2. Forsberg, L. A., Gisselsson, D., Strömbeck, B., Sterner, M., & Ståhl, F. (2023). Paternal discrepancy due to ...

May 1, 2025 View →
Массаж грудной клетки новорожденного. Для правильного ...
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doi: 10.1056/NEJMoa013452 2. Forsberg, L. A., Gisselsson, D., Strömbeck, B., Sterner, M., & Ståhl, F. (2023). Paternal discrepancy due to ...

Apr 30, 2025 View →
Frase de Cesar Lombroso #YOSOYFMC #REACCIONFORENSE ...
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DOI: 10.1056/NEJMoa013452. View all 12 comments. manosfriascorazoncaliente Si terminas de leer capaz que tenés suerte de entender. miriestefa ...

Jun 4, 2024 View →
Una mujer con dos tipos de ADN: Karen Keegan, una mujer de ...
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... raro, muestra que la biología humana puede ser mucho más intrincada de lo que se pensaba. DOI: 10.1056/NEJMoa013452".

Jun 3, 2024 View →
Una mujer con dos tipos de ADN: Karen Keegan, una mujer de ...
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... 10.1056/NEJMoa013452. Log in ·

Jun 3, 2024 View →
Federación - Una mujer con dos tipos de ADN: Karen Keegan, una ...
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... 10.1056/NEJMoa013452 | Facebook. Log in. Facebook. No photo description available. Federación Internacional de Criminología y ... Jun 3, 2024 · ...

Jun 3, 2024 View →
Comunidad Biológica
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... intrincada de lo que se pensaba. DOI: 10.1056/NEJMoa013452 · No photo description available. Alejandro Fernández and 540 others ·

May 29, 2024 View →
typage HLA – Réalités Biomédicales
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... 10.1056/NEJMoa013452. Gilgenkrantz S. Nouveaux regards sur les mosaïques et chimères humaines. Med Sci (Paris). 2002 Oct;18(10):925-2. doi ...

May 28, 2024 View →
Génétique : histoires incroyables de chimères humaines naturelles ...
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... 10.1056/NEJMoa013452. Gilgenkrantz S. Nouveaux regards sur les mosaïques et chimères humaines. Med Sci (Paris). 2002 Oct;18(10):925-2. doi ...

May 21, 2024 View →
Bonsoir à tous, Et si on en parlait, depuis la fin des tableurs exportés ...
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org/doi/full/10.1056/NEJMoa013452 2. Cas de Lydia Fairchild (USA, 2002-2004) Tests ADN négatifs lors d'un contrôle judiciaire — elle ...

Mar 18, 2024 View →
Очень интересно читать посты людей, которые говорят о себе ...
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doi: 10.1056/NEJMoa013452 2. Forsberg, L. A., Gisselsson, D., Strömbeck, B., Sterner, M., & Ståhl, F. (2023). Paternal discrepancy due to ...

Dec 29, 2023 View →
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org/doi/full/10.1056/NEJMoa013452. https://embryo.asu.edu/pages/case-lydia-fairchild-and-her-chimerism-2002. https://www.theguardian.com/books ...

Sep 3, 2023 View →
为啥有的猫咪长得这么怪?|dna|宠物|嵌合体|猫咪|细胞|胡须|驯养动物 ...
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... 10.1056/NEJMoa013452. [4] Lyons L A , Buckley R M , Harvey R J , et al. Mining the 99 Lives Cat Genome Sequencing Consortium database ...

Mar 21, 2023 View →
¿Conocías sobre el quimerismo tetragamético? El quimerismo, la ...
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... NEJMoa013452 [doi] 12015394 https://www.nejm.org/doi/full/10.1056/NEJMoa013452. New England Journal of Medicine May 16, 2002 346(20):1545 ...

Mar 9, 2022 View →
Trust me, I'm a "Biologist" | Facebook
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https://www.nejm. org/doi/full/10.1056/NEJMoa013452. nejm.org. Disputed Maternity Leading to Identification of. 4 yrs. 1. Cryptopsaras Couesii.

Feb 17, 2022 View →
TIL Karen Keegan needed a kidney transplant, so blood relatives ...
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... the case: https://www.nejm.org/doi/full/10.1056/NEJMoa013452?query=TOC · FallsOffCliffs12. • 5y ago. Used to work in a hospital and we ...

Nov 12, 2020 View →
Bilateral gynandromorph In Powdermill Bird Banding's nearly 60 ...
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org/doi/full/10.1056/NEJMoa013452?f bclid=IwAR0ilvd6MDUv1iJYqsoEao1806 Rp_6jeu8QiI_euUAq-gQxCkj_jXFdR1KQ https://www.scientificamerican. com ...

Sep 24, 2020 View →
Gatto chimera: geneticamente è il suo stesso gemello fraterno, ma ...
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https://www.nejm.org/doi/full/10.1056/NEJMoa013452. Ecco qualcosa di ancora più bizzarro: https://www.livescience.com/23490-fetal-dna-mom ...

Jul 21, 2020 View →
Gato quimera: genéticamente es su propio gemelo fraterno, pero un ...
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https://www.nejm.org/doi/full/10.1056/NEJMoa013452. Aquí hay algo aún más raro: https://www.livescience.com/23490-fetal-dna-mom-brain.html.

Jul 21, 2020 View →
Chimära-Katze: genetisch gesehen ihr eigener Zwilling, aber eine ...
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https://www.nejm.org/doi/full/10.1056/NEJMoa013452. Hier ist was noch Verrückteres: https://www.livescience.com/23490-fetal-dna-mom-brain ...

Jul 21, 2020 View →
Gato quimera: geneticamente é seu próprio gêmeo fraterno, mas um ...
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https://www.nejm.org/doi/full/10.1056/NEJMoa013452. E olha só que bizarro: https://www.livescience.com/23490-fetal-dna-mom-brain.html.

Jul 21, 2020 View →
Kimera kedi: genetik olarak kendi ikiz kardeşi, ama bireysel bir kedi ...
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https://www.nejm.org/doi/full/10.1056/NEJMoa013452. Şu daha da tuhaf: https://www.livescience.com/23490-fetal-dna-mom-brain.html.

Jul 21, 2020 View →
Chimera cat: genetically it's own fraternal twin, but an individual cat ...
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https://www.nejm.org/doi/full/10.1056/NEJMoa013452. Here's something even more bizarre: https://www.livescience.com/23490-fetal-dna-mom-brain ...

Jul 21, 2020 View →
Can a person inherit dna (giving them two sets like a chimera) from ...
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https://www.nejm.org/doi/full/10.1056/NEJMoa013452. Hope this helps! Edit: If you are thinking of the Episode of House MD where they had a ...

Dec 10, 2019 View →
Farklı babalardan gelen iki embriyonun birleşip bir insan kimera ...
Reddit

[İnsan kimeraları](https://en.wikipedia.org/wiki/Chimera_(genetics)) kesinlikle mümkün](https://www.nejm.org/doi/full/10.1056/NEJMoa013452).

Apr 4, 2019 View →
Chimerism: Definition, Symptoms, Testing, Diagnosis, and More
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https://www.nejm.org/doi/full/10.1056/NEJMoa013452; Yunis EJ, et al. (2007). Chimerism and tetragametic chimerism in humans: Implications in ...

Nov 29, 2018 View →
Is it posible for two people with blue eyes to have a child with brown ...
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Being a chimera can be difficult to prove. You never know what DNA is found where. https://www.nejm.org/doi/full/10.1056/NEJMoa013452.

May 30, 2018 View →
a creature in Greek mythology that's part lioness, part goat, and part ...
Reddit

... article, that at the time, in 2008, there were only two cases known. http://www.nejm.org/doi/full/10.1056/NEJMoa013452. [deleted]. • 8y ago.

Apr 8, 2018 View →
Ahmad Alomari - أحمد الحجي - هل يمكن أن تولد بأعضاء لطفلين ...
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org/doi/full/10.1056/NEJMoa013452#discu ssion. nejm.org. Disputed Maternity Leading to Identification of Tetragametic. 8 yrs. 3. Ahmed Subhi.

Jul 1, 2017 View →
3 Human Chimeras That Already Exist | Scientific American
Blogs

A chimera is essentially a single organism that's made up of cells from two or more "individuals"—that is, it contains two sets of DNA ...

Aug 8, 2016 View →
When You're Not Just Yourself - As Many Exceptions As Rules
Blogs

... 10.1056/NEJMoa013452. Yu, Q., Li, Q., Gao, S., Su, Y., & Deng, Z. (2011). Congenital Tetragametic Blood Chimerism Explains a Case of ...

Sep 9, 2015 View →