Hypertension September 2002 PMID 12215479

Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity.

Susumu Watanabe, Duk-Hee Kang, Lili Feng, Takahiko Nakagawa, John Kanellis, Hui Lan, Marilda Mazzali, Richard J Johnson

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Mentions

20
Peak: 9 in Apr 2023
across 4 sources since Aug 2022

Extended reach

781,100
potential audience

Total likes

21,422

Video views

716,895

Mentions per month

Aug 2022 – Feb 2024

Where it's discussed

  • X / Twitter14 posts
  • YouTube2 videos
  • Facebook2 posts
  • Blogs2 articles

AI synopsis

What people are saying

The discussions reflect a balanced view, with phrases like 'myth' and 'truth revealed' highlighting a reevaluation of metabolic syndrome explanations. Posts reference mechanisms such as uricase inhibition leading to increased salt sensitivity and blood pressure, demonstrating a moderate level of engagement and interest based on scientific concepts, suggesting they find the research relevant but are not deeply immersed in complex details.

AgreementModerate agreement

Most discussions acknowledge the importance of the research, with some suggesting it challenges common perceptions about metabolic syndrome and salt sensitivity.

InterestModerate interest

Posts show moderate interest, often referencing the implications of uric acid and salt sensitivity but not engaging deeply with technical details.

EngagementModerate engagement

There is some depth, exemplified by mentions of mechanisms in rats and calls to rethink metabolic health strategies.

ImpactModerate impact

The discussions could influence perspectives on diet and health, emphasizing the significance of uric acid's role in salt sensitivity and cardiovascular risk.

Abstract in brief

  • Humans developed elevated uric acid levels due to a mutation in the urate oxidase gene during the Miocene, which helped maintain blood pressure when salt intake was low.
  • In rats, mild hyperuricemia raises blood pressure through mechanisms involving the renin system and increases salt sensitivity by causing vascular damage, partly through smooth muscle cell proliferation.
  • While this adaptation helped early humans survive, it may now contribute to the modern rise in cardiovascular diseases related to salt sensitivity and vascular damage.]

Top posts

Most liked on X and Bluesky
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@AdiG1993 · X

10) This study showed that in rats with a low salt diet, blocking of the uricase enzyme --> raised SUA --> afferent arteriolar smooth muscle proliferation --> renal hypoperfusion --> RAAS activation --> increased salt sensitivity! https://t.co/cz9merGeq6

Aug 21, 2022 · 26 likes · 1 share · 36,621 followers View post →
Nicholas Steel
@bogizemlja · X

The Biggest Myth Around Metabolic Syndrome (Syndrome X) https://t.co/KgaUcuGYe9 via @YouTube

Apr 30, 2023 · 2 likes · 1 share · 14,724 followers View post →
BOBObro kake
@BobobroK · X

The Biggest Myth Around Metabolic Syndrome (Syndrome X) https://t.co/Zc8HmWVfqq

Apr 30, 2023 · 3,387 followers View post →
Indy
@indy_yet · X

RT @AdiG1993: 10) This study showed that in rats with a low salt diet, blocking of the uricase enzyme --> raised SUA --> afferent arteriola…

Aug 21, 2022 · 1 share · 2,918 followers View post →
Castor
@Castoropollux2 · X

De största myterna om det metaboliska syndromet! Saltkänslighet beror på för mycket fruktos, brist på Kalium. Doktor Transparent vill ge dig medicin & att du ska minska på det raffinerade saltet (natriumklorid) som inte ens innehåller kalium längre. https://t.co/f36M0iBKud

Apr 30, 2023 · 2,913 followers View post →
Grumpy Rabbit (Alan Lovejoy)
@Alan_L_Lovejoy · X

_The Biggest Myth Around Metabolic Syndrome (Syndrome X)_ Metabolic Syndrome ("Syndrome X") is NOT a "disease." It's a DEFENSE MECHANISM that's the body's optimal response to a bad diet. https://t.co/eVb5LoqBkD

May 1, 2023 · 1,037 followers View post →

All mentions

my640
@my6401 · X

The Shocking Truth About Metabolic Syndrome (Syndrome X) Revealed https://t.co/u2fTruDfZv via @YouTube

Feb 3, 2024 · 601 followers View post →
Михаил Рохин 99+
@MikhailRokhin · X

Реальная причина метаболического синдрома. Откажитесь от этого https://t.co/rtMnjSAP86 через @YouTube ...и консультация у #эндокринолог ( #гормоны щитовидки, гипофиза и надпочечников) ... иммунная система <-> эндокринная система <-> нервная система

Jun 17, 2023 · 62 followers View post →
Grumpy Rabbit (Alan Lovejoy)
@Alan_L_Lovejoy · X

_The Biggest Myth Around Metabolic Syndrome (Syndrome X)_ Metabolic Syndrome ("Syndrome X") is NOT a "disease." It's a DEFENSE MECHANISM that's the body's optimal response to a bad diet. https://t.co/eVb5LoqBkD

May 1, 2023 · 1,037 followers View post →
MENACE TO STATUS QUO
@Iamthematata · X

@amgodfreypeter @amerix https://t.co/0goEEFMZyg

May 1, 2023 · 333 followers View post →
My Info
@wingchun216 · X

The Biggest Myth Around Metabolic Syndrome (Syndrome X) We don't need fructose for survival anymore—in fact, it's hurting us. If you have problems related to metabolic syndrome, try avoiding fructose in all forms. https://t.co/zH3WR4YTNB via @YouTube

Apr 30, 2023 · 268 followers View post →
Castor
@Castoropollux2 · X

De största myterna om det metaboliska syndromet! Saltkänslighet beror på för mycket fruktos, brist på Kalium. Doktor Transparent vill ge dig medicin & att du ska minska på det raffinerade saltet (natriumklorid) som inte ens innehåller kalium längre. https://t.co/f36M0iBKud

Apr 30, 2023 · 2,913 followers View post →
BOBObro kake
@BobobroK · X

The Biggest Myth Around Metabolic Syndrome (Syndrome X) https://t.co/Zc8HmWVfqq

Apr 30, 2023 · 3,387 followers View post →
Rick D.
@RickDelmonico · X

https://t.co/tb3yS4K6LA

Apr 30, 2023 · 486 followers View post →
Andy Spark
@AndySpark25 · X

@LCinTirol @imed_tweets @MedUni_Wien Das gab es heute zum Thema Fruktose https://t.co/AAnIMYFGdF

Apr 30, 2023 · 125 followers View post →
Zooma
@News_Rants_Fun · X

RT @bogizemlja: The Biggest Myth Around Metabolic Syndrome (Syndrome X) https://t.co/KgaUcuGYe9 via @YouTube

Apr 30, 2023 · 1 share · 712 followers View post →
Nicholas Steel
@bogizemlja · X

The Biggest Myth Around Metabolic Syndrome (Syndrome X) https://t.co/KgaUcuGYe9 via @YouTube

Apr 30, 2023 · 2 likes · 1 share · 14,724 followers View post →
elizabeth da silva
@elizabeth771ga · X

The Biggest Myth Around Metabolic Syndrome (Syndrome X) https://t.co/Pq1P6n8aBr via @YouTube

Apr 30, 2023 · 11 followers View post →
Indy
@indy_yet · X

RT @AdiG1993: 10) This study showed that in rats with a low salt diet, blocking of the uricase enzyme --> raised SUA --> afferent arteriola…

Aug 21, 2022 · 1 share · 2,918 followers View post →
.
@AdiG1993 · X

10) This study showed that in rats with a low salt diet, blocking of the uricase enzyme --> raised SUA --> afferent arteriolar smooth muscle proliferation --> renal hypoperfusion --> RAAS activation --> increased salt sensitivity! https://t.co/cz9merGeq6

Aug 21, 2022 · 26 likes · 1 share · 36,621 followers View post →