10) This study showed that in rats with a low salt diet, blocking of the uricase enzyme --> raised SUA --> afferent arteriolar smooth muscle proliferation --> renal hypoperfusion --> RAAS activation --> increased salt sensitivity! https://t.co/cz9merGeq6
Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity.
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Aug 2022 – Feb 2024Where it's discussed
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X / Twitter14 posts
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YouTube2 videos
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Facebook2 posts
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Blogs2 articles
AI synopsis
What people are saying
The discussions reflect a balanced view, with phrases like 'myth' and 'truth revealed' highlighting a reevaluation of metabolic syndrome explanations. Posts reference mechanisms such as uricase inhibition leading to increased salt sensitivity and blood pressure, demonstrating a moderate level of engagement and interest based on scientific concepts, suggesting they find the research relevant but are not deeply immersed in complex details.
Most discussions acknowledge the importance of the research, with some suggesting it challenges common perceptions about metabolic syndrome and salt sensitivity.
Posts show moderate interest, often referencing the implications of uric acid and salt sensitivity but not engaging deeply with technical details.
There is some depth, exemplified by mentions of mechanisms in rats and calls to rethink metabolic health strategies.
The discussions could influence perspectives on diet and health, emphasizing the significance of uric acid's role in salt sensitivity and cardiovascular risk.
Abstract in brief
- Humans developed elevated uric acid levels due to a mutation in the urate oxidase gene during the Miocene, which helped maintain blood pressure when salt intake was low.
- In rats, mild hyperuricemia raises blood pressure through mechanisms involving the renin system and increases salt sensitivity by causing vascular damage, partly through smooth muscle cell proliferation.
- While this adaptation helped early humans survive, it may now contribute to the modern rise in cardiovascular diseases related to salt sensitivity and vascular damage.]
Top posts
Most liked on X and BlueskyThe Biggest Myth Around Metabolic Syndrome (Syndrome X) https://t.co/KgaUcuGYe9 via @YouTube
The Biggest Myth Around Metabolic Syndrome (Syndrome X) https://t.co/Zc8HmWVfqq
RT @AdiG1993: 10) This study showed that in rats with a low salt diet, blocking of the uricase enzyme --> raised SUA --> afferent arteriola…
De största myterna om det metaboliska syndromet! Saltkänslighet beror på för mycket fruktos, brist på Kalium. Doktor Transparent vill ge dig medicin & att du ska minska på det raffinerade saltet (natriumklorid) som inte ens innehåller kalium längre. https://t.co/f36M0iBKud
_The Biggest Myth Around Metabolic Syndrome (Syndrome X)_ Metabolic Syndrome ("Syndrome X") is NOT a "disease." It's a DEFENSE MECHANISM that's the body's optimal response to a bad diet. https://t.co/eVb5LoqBkD
All mentions
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Metabolic Syndrome: Myths, Facts, and Evolutionary Insights
Metabolic syndrome may be a protective mechanism. This video explores the myth surrounding metabolic syndrome, which includes conditions such as abdominal obesity, high blood pressure, and more, while drawing insights…
The Shocking Truth About Metabolic Syndrome (Syndrome X) Revealed https://t.co/u2fTruDfZv via @YouTube
Реальная причина метаболического синдрома. Откажитесь от этого https://t.co/rtMnjSAP86 через @YouTube ...и консультация у #эндокринолог ( #гормоны щитовидки, гипофиза и надпочечников) ... иммунная система <-> эндокринная система <-> нервная система
_The Biggest Myth Around Metabolic Syndrome (Syndrome X)_ Metabolic Syndrome ("Syndrome X") is NOT a "disease." It's a DEFENSE MECHANISM that's the body's optimal response to a bad diet. https://t.co/eVb5LoqBkD
@amgodfreypeter @amerix https://t.co/0goEEFMZyg
The Biggest Myth Around Metabolic Syndrome (Syndrome X) We don't need fructose for survival anymore—in fact, it's hurting us. If you have problems related to metabolic syndrome, try avoiding fructose in all forms. https://t.co/zH3WR4YTNB via @YouTube
De största myterna om det metaboliska syndromet! Saltkänslighet beror på för mycket fruktos, brist på Kalium. Doktor Transparent vill ge dig medicin & att du ska minska på det raffinerade saltet (natriumklorid) som inte ens innehåller kalium längre. https://t.co/f36M0iBKud
The Biggest Myth Around Metabolic Syndrome (Syndrome X) https://t.co/Zc8HmWVfqq
https://t.co/tb3yS4K6LA
@LCinTirol @imed_tweets @MedUni_Wien Das gab es heute zum Thema Fruktose https://t.co/AAnIMYFGdF
RT @bogizemlja: The Biggest Myth Around Metabolic Syndrome (Syndrome X) https://t.co/KgaUcuGYe9 via @YouTube
The Biggest Myth Around Metabolic Syndrome (Syndrome X) https://t.co/KgaUcuGYe9 via @YouTube
The Biggest Myth Around Metabolic Syndrome (Syndrome X) https://t.co/Pq1P6n8aBr via @YouTube
RT @AdiG1993: 10) This study showed that in rats with a low salt diet, blocking of the uricase enzyme --> raised SUA --> afferent arteriola…
10) This study showed that in rats with a low salt diet, blocking of the uricase enzyme --> raised SUA --> afferent arteriolar smooth muscle proliferation --> renal hypoperfusion --> RAAS activation --> increased salt sensitivity! https://t.co/cz9merGeq6
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