J Urol June 2003 PMID 12771769

The influence of paternal age on down syndrome.

Harry Fisch, Grace Hyun, Robert Golden, Terry W Hensle, Carl A Olsson, Gary L Liberson

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Peak: 3 in Feb 2023

across 4 sources since Mar 2020

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Mar 2020 – Dec 2025

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What people are saying

The overall trend reflects support for the scientific findings, with comments like the Columbia Presbyterian Study linking paternal age to Down syndrome, and others debating the relative influence of paternal versus maternal age. The tone varies from informative to skeptically critical, with examples such as mentions of specific statistics (e.g., 50% paternal contribution) and references to research, demonstrating meaningful engagement and recognition of the study's significance.

AgreementModerate agreement

Most discussions acknowledge the role of paternal age in Down syndrome risk, aligning with the publication's findings.

InterestModerate interest

Users show moderate curiosity by referencing studies, statistics, and debates about paternal versus maternal influence.

EngagementModerate engagement

Many comments analyze, question, or cite scientific studies, indicating a thoughtful level of engagement.

ImpactModerate impact

The discussions highlight awareness and concern about reproductive risks, suggesting the article influences public understanding.

Abstract in brief

Children born to older parents, especially those aged 35 and above, are at increased risk for genetic conditions like Down syndrome, with maternal age being a well-known factor and paternal age also contributing when combined with advanced maternal age.
Data from 1983 to 1997 showed a significant rise in the number of older parents, especially mothers over 35, and a notable paternal age effect on Down syndrome risk emerged when mothers were 40 or older, with paternal age accounting for about 50% of the risk in this group.
The study suggests that advanced paternal age, particularly when coupled with older maternal age, plays a crucial role in the likelihood of Down syndrome, which could reflect broader genetic risks associated with older fathers.

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All mentions

Impact of Paternal Age on Down Syndrome Risk in Prenatal Diagnostics

Children born to older parents, especially those aged 35 and above, are at increased risk for genetic conditions like Down syndrome. The study highlights the significant role of advanced paternal age, especially when…

ፍቅሪ ምስ ኩሉ Fqri Ms Kulu · Mar 30, 2020 576 views

Impact of Parental Age on Down Syndrome Risk

Children born to older parents, especially those aged 35 and above, are at increased risk for genetic conditions like Down syndrome, with maternal age being a well-known factor and paternal age also contributing when…

Maria Magdalena Imas Nababan · Nov 17, 2024 47 views

よしかげ@胚培養

@embryo_yoshi · X

@patoracyun 返事出来ないようなのでここで代えさせていただきますまずこちら（https://t.co/zfbKCWT8xT）ですが、2003年の古い報告で概要しか見れず、どの程度の増加をしたのか？は一切わかりません。染色体異常への影響はあっても小さく、女性の加齢のそれ程では無いだろうという意見への反証になり得ません

Dec 13, 2025 · 677 followers View post →

カニィー

@patoracyun · X

@embryo_yoshi 35歳以上の両親から生まれた乳児の数が劇的に増加 15年間の研究期間中、35歳以上の母親と父親の数はそれぞれ111%と60%増加https://t.co/gVfTSOgwrN もういっちょ

Dec 13, 2025 · 205 followers View post →

Selenium Ciencia y Cerebro

@Centro_Selenium · X

@CounterTyrannyX @AntiCommieBecca @clairlemon "the paternal contribution to Down syndrome was 50%." https://t.co/WcLcEBxMmA and autism IS A BIG DEAL

Oct 10, 2025 · 1,026 followers View post →

Freya

@FreyaWhitethorn · X

@YouMayCallMeV1 @_BeeHolder_ @Trail_and_Track 1. Down Syndrome: Fisch, H., et al. (2003). "The Influence of Paternal Age on Down Syndrome." Journal of Urology, 169(6), 2275–2278. Available at: https://t.co/o02qCkIa38 This study found that advanced paternal age, particularly when combined with maternal age over

Jul 26, 2025 · 1 like · 822 followers View post →

Rachel Clausen

@RenContessa · X

@KaseZashe53875 @JillL33007432 @DonMcDo85140418 @RealDianeYap And look! Men over 35 have similar risk of fathering a Downs child as does a woman over 40. Interesting. https://t.co/dKq4jnoQoN.

Jul 10, 2025 · 1 like · 1,469 followers View post →

derpman76

@derpman76148 · X

@demroach @Xheuz @Tyler567989334 @TheRoyalSerf that is incorrect, paternal age only starts to influence at age 35 according to this study https://t.co/QGwnLG8TOV and that is basically what everything i have read said that the egg degeneration is the cause due to the TYPE of mutations associated with degeneration v replication

Mar 27, 2025 · 130 followers View post →

tjhoea315

@tjhoea315 · X

@kentan990ren @sdenta Kualitas sperma menurun juga di usia 35+ yang berhubungan dengan meningkatnya down syndrome https://t.co/g5Mgq8SSjQ

Mar 27, 2024 · 4 likes · 104 followers View post →

Jadwiga Cogiel-M

@jagoooodkac · X

@domie_homie @ri3nka @outsiderr1988 @DawidSolaris https://t.co/KfDeg7FnyW

Feb 15, 2024 · 34 followers View post →

Selenium Ciencia y Cerebro

@Centro_Selenium · X

@SeCrisAle @Gabisilandia Edad de madre y padre influyen. quizá los chilenos se ponen a tener hijos más viejos. (No tengo el dato) https://t.co/WcLcEBxex2

Dec 13, 2023 · 1,026 followers View post →

PawelDSM

@PawelDSM · X

@nicegirl45678 @CatchynickNick wiek ojca ma wpływ na choroby jeśli matka ma powyżej 35 lat, to jest badanie, na które się powołujesz: https://t.co/RLh6hYIvYz

Oct 26, 2023 · 2 likes · 18,155 followers View post →

PawelDSM

@PawelDSM · X

@nicegirl45678 @CatchynickNick Absolutna bzdura, jakość spermy spada o 54% w wieku 55 lat mężczyzny, co i tak gwarantuje mu dalszą płodność przy produkcji milionów plemników dziennie. badanie, które cytujesz pochodzi z: https://t.co/RLh6hYIvYz i jakośc liczyła się tylko w przypadku kobiet po 35 roku życia

Oct 26, 2023 · 18,155 followers View post →

Chicago Honey Bear

@ChiHoneyBear · X

@xbtGBH @Attractiveincel Fun fact: humans being born with Down syndrome is primarily linked to poor sperm, not so much old ova https://t.co/LrSUUtzE8j https://t.co/dEoOVfVMDk https://t.co/XMEOdbfKDD https://t.co/iIbmBf7ATz

Sep 26, 2023 · 1,913 followers View post →

avekado

@elektroink1 · X

RT @karanlikruya1: @eslal_ Bu iş google'dan alıntı yaparak olmaz. Aynı hatalı bilgi dolaşıyor. Hastalık bilgisi de yanlış. Çalışmalar erk…

Sep 26, 2023 · 1 share · 11 followers View post →

Karanlikruya

@karanlikruya1 · X

Sep 26, 2023 · 4 likes · 1 share · 19,095 followers View post →

Selenium Ciencia y Cerebro

@Centro_Selenium · X

@Martzelo_nek The influence of paternal age on down syndrome https://t.co/WcLcEBxex2 Columbia Presbyterian Study Links Down Syndrome, Father's Age https://t.co/aSMhfLOy6d

May 4, 2023 · 1,026 followers View post →

Chan Phka Vampire

@CherryCinnaMoon · X

@SouthernApeman Yes, that's literally OP's topic. I didn't decide. They didn't conclude risk disappears w/ mother's age, nor the only study finding paternal age matters too. Need to be more research, as I said, but it's the findings. & Dr Fisch https://t.co/xlI3WSFQH9 https://t.co/AmAJN8Ppf8 https://t.co/dGG3tFOmeW

Mar 21, 2023 · 438 followers View post →

Esam Shahlol, MD

@EsamShahlol · X

Feb 25, 2023 · 10 likes · 1 share · 4,814 followers View post →

Jenny Ure

@JennyUre · X

https://t.co/dgP4LDZt93 https://t.co/UznTbnHkYx

Feb 1, 2023 · 541 followers View post →

0reszn

@PoshPink28 · X

@doctorhealthed1 @instablog9ja I’ll do you one better......see how the article didn’t just mention mothers? Better tell your boys the truth about their spoilt milk. Y’all have biological clocks as well as women. https://t.co/064EDMXJHN

Feb 1, 2023 · 645 followers View post →

Ganetika

@SherlockGantan · X

...dan juga Down syndrome (kalau ibunya juga tua pas punya anak). https://t.co/n5zMiEtqGz https://t.co/dYpocdWZwj

Feb 24, 2021 · 2,435 followers View post →

1ceuponadoctor

@1ceuponadoctor · X

@caseyamaefule @BolaAde11 @godwin_france @Wizarab10 CLINICAL UROLOGY: Original Articles | Journal of Urology https://t.co/kzXDXZnwyI

Dec 7, 2020 · 2 likes · 126 followers View post →

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The influence of paternal age on down syndrome.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Impact of Paternal Age on Down Syndrome Risk in Prenatal Diagnostics

Impact of Parental Age on Down Syndrome Risk