PubHawk
Ann Intern Med December 1992 PMID 1443971

Hormone therapy to prevent disease and prolong life in postmenopausal women.

D Grady, S M Rubin, D B Petitti, C S Fox, D Black, B Ettinger, V L Ernster, S R Cummings

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Mentions

25
Peak: 3 in Sep 2023
across 4 sources since Sep 2023

Extended reach

140,183
potential audience

Total likes

22

Video views

32

Mentions per month

Sep 2023 – Mar 2024

Where it's discussed

  • News15 articles
  • X / Twitter4 posts
  • Blogs4 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reveal a focus on the challenges of synthesizing observational studies about hormone therapy, exemplified by remarks such as 'Bias x Bias still equals bias' and references to meta-analysis limitations, emphasizing scientific skepticism and cautious interpretation rather than immediate clinical implications. The tone underscores a critical, analytical approach to evaluating the published research.

AgreementModerate agreement

Posts demonstrate caution about the validity of meta-analyses, showing some agreement that bias complicates interpretations.

InterestModerate interest

Discussions show moderate interest, focusing on methodological challenges rather than the direct implications of hormone therapy.

EngagementModerate engagement

Comments suggest thoughtful consideration and critical engagement with the topic, referencing studies and meta-analysis concepts.

ImpactNeutral impact

The discussion raises awareness about research limitations but does not directly influence clinical practice or policy debates yet.

Abstract in brief

  • The review examines the risks and benefits of hormone therapy (estrogen alone or with progestin) for postmenopausal women considering long-term use to prevent disease or extend life, highlighting benefits like reduced risk of coronary heart disease and hip fractures, but also increased risks of endometrial and possibly breast cancer.
  • The study uses meta-analysis and lifetable methods to estimate how hormone therapy influences lifetime disease probabilities and life expectancy, finding that adding progestin can mitigate endometrial cancer risk in women with uteri, though the effects on other diseases are not well understood.
  • The authors suggest hormone therapy may be advisable for women who have had a hysterectomy or are at high risk of coronary heart disease, but the optimal approach for other women remains uncertain due to unresolved safety questions.
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Top posts

Most liked on X and Bluesky
John Mandrola, MD
@drjohnm · X

Thanks FM. I’m still learning but I’m pretty sure you could meta-analyze more than 20 biased studies and you still get bias. Exhibit A: HRT in post menopausal women https://t.co/ITut1AoHmK https://t.co/CYRmzy6ehM

Sep 11, 2023 · 22 likes · 2 shares · 69,105 followers View post →
John Mandrola, MD
@drjohnm · X

@DrBendary Me too. But even meta-analyzing observational studies seems tough. Bias x Bias still equals bias -- see Grady et al. https://t.co/czMnSqFjMH

Nov 2, 2023 · 69,105 followers View post →
Bartosz Hudzik MD PhD FESC FACC
@BartoszHudzik · X

RT @drjohnm: Thanks FM. I’m still learning but I’m pretty sure you could meta-analyze more than 20 biased studies and you still get bias.…

Sep 12, 2023 · 2 shares · 1,422 followers View post →
Camilla Alderighi
@camialderighi · X

RT @drjohnm: Thanks FM. I’m still learning but I’m pretty sure you could meta-analyze more than 20 biased studies and you still get bias.…

Sep 12, 2023 · 2 shares · 508 followers View post →

All mentions

John Mandrola, MD
@drjohnm · X

@DrBendary Me too. But even meta-analyzing observational studies seems tough. Bias x Bias still equals bias -- see Grady et al. https://t.co/czMnSqFjMH

Nov 2, 2023 · 69,105 followers View post →
Bartosz Hudzik MD PhD FESC FACC
@BartoszHudzik · X

RT @drjohnm: Thanks FM. I’m still learning but I’m pretty sure you could meta-analyze more than 20 biased studies and you still get bias.…

Sep 12, 2023 · 2 shares · 1,422 followers View post →
Camilla Alderighi
@camialderighi · X

RT @drjohnm: Thanks FM. I’m still learning but I’m pretty sure you could meta-analyze more than 20 biased studies and you still get bias.…

Sep 12, 2023 · 2 shares · 508 followers View post →
John Mandrola, MD
@drjohnm · X

Thanks FM. I’m still learning but I’m pretty sure you could meta-analyze more than 20 biased studies and you still get bias. Exhibit A: HRT in post menopausal women https://t.co/ITut1AoHmK https://t.co/CYRmzy6ehM

Sep 11, 2023 · 22 likes · 2 shares · 69,105 followers View post →