Physiol Rev January 2004 PMID 14715912

Long-term potentiation and memory.

M A Lynch

Mentions

65
Peak: 15 in May 2021
across 4 sources since Feb 2019

Extended reach

226,548
potential audience

Total likes

406

Video views

14,451

Mentions per month

Feb 2019 – Aug 2025

Where it's discussed

  • X / Twitter56 posts
  • Blogs5 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

Throughout the discussions, there is recognition of key concepts such as the role of NMDAR signaling, microglia, and ultrasound techniques in memory modulation, using supportive and technical language that demonstrates both appreciation and a desire to connect research to broader applications.

AgreementModerate agreement

Most discussions acknowledge the importance of understanding long-term potentiation and its relation to memory, expressing support for the article's focus and findings.

InterestModerate interest

Posts show moderate interest, highlighting new mechanisms like ultrasound and microglia's role, indicating curiosity but not overwhelming enthusiasm.

EngagementModerate engagement

Commenters engage with specific mechanisms and experimental techniques mentioned in the publication, reflecting a desire to understand deep scientific details.

ImpactModerate impact

The discussions emphasize that the research could pave the way for therapeutic advances, suggesting a positive view on its potential influence.

Abstract in brief

  • The article discusses the challenge of understanding the cellular and molecular processes involved in learning and memory, especially focusing on longterm potentiation (LTP) in the hippocampus, which is a key model for studying synaptic plasticity.
  • Advances in neuroscience techniques, such as gene knockout and overexpression, have helped researchers better understand how changes in cell signaling and gene transcription relate to learning, particularly spatial learning.
  • The review emphasizes the effects of stress on spatial memory, LTP, and the importance of using transgenic animals to explore how different variables influence memory formation and synaptic changes.]

Top posts

Most liked on X and Bluesky
Русские летописи и кот Онфим
@letopisi_rus · X

Чтобы вести срач на должном уровне, прочел статью Transgenerational Rescue of a Genetic Defect in Long-Term Potentiation and Memory Formation by Juvenile Enrichment и обзор Epigenetic Influence of Social Experiences Across the Lifespan. Твитор образовательный

Jul 16, 2020 · 59 likes · 31,377 followers View post →
Juergen Goetz
@AustraliaGoetz · X

https://t.co/likPIz5ydS (Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling - now online)

May 26, 2021 · 32 likes · 9 shares · 356 followers View post →
molecularpsychiatry
@molpsychiatry · X

Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling. By Daniel G. Blackmore et al. @QldBrainInst #ultrasound #lifu #potentiation #memory #OpenAccess https://t.co/XFIspxF5zH https://t.co/LZmnaMgFKP

Feb 23, 2022 · 17 likes · 2 shares · 2,352 followers View post →
Focused Ultrasound Foundation
@FUSFoundation · X

New study just published in Molecular Psychiatry from @AustraliaGoetz and the team at the @QldBrainInst - "Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling" https://t.co/S5Oq3Z9tEF

May 27, 2021 · 7 likes · 2 shares · 3,330 followers View post →
Nicole Laurent, LMHC
@KetoCounselor · X

While transient mitochondrial reactive oxygen species (ROS) production is beneficial for synaptic signaling, long-term potentiation, and memory-related mechanisms, mitochondrial dysfunction causes ROS overproduction and oxidative damage. (8/13)

Apr 9, 2023 · 5 likes · 9,127 followers View post →
Sun-Fire
@MediaCreatorSMM · X

Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling | Molecular Psychiatry https://t.co/uyfau8wtOS

Jan 20, 2025 · 4 likes · 110 followers View post →

All mentions

B Pradeep
@BpradeepHpy · X

Long term potentiation https://t.co/8MYHL7D5Cg

Aug 26, 2025 · 1 like · 48 followers View post →
Krzysztof Potempa
@BRAINCURES · X

One of the most compelling problems in neuroscience is to identify the mechanisms underlying memory, and although a great deal of progress has been made in the past few decades, it remains a significant challenge https://t.co/E7f3qwvjgy

May 31, 2025 · 2,667 followers View post →
GlioDAO
@glio_dao · X

@NatureNeuro @boazmohar @svoboda314 @nspruston @euforna @HHMIJanelia @AllenInstitute This provides a crucial dataset for understanding long-term potentiation and memory stability

Apr 2, 2025 · 1 like · 439 followers View post →
Daniel Brittain Dugger
@dbdugger · X

@ejustin46 From the article above. "Activated microglia, in turn, release IL-1β, which has been shown to impact long-term potentiation and memory by affecting hippocampal neurons bearing IL-1β receptors."

Apr 1, 2025 · 17,873 followers View post →
Sun-Fire
@MediaCreatorSMM · X

Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling | Molecular Psychiatry https://t.co/uyfau8wtOS

Jan 20, 2025 · 4 likes · 110 followers View post →
Pol Pifer
@polpifer · X

Discovering the intricate mechanisms of memory maintenance, Tsokas et al. reveal that the interaction between KIBRA and PKMζ is critical for sustaining long-term potentiation and memory in the brain

Jun 27, 2024 · 39 followers View post →
Pol Pifer
@polpifer · X

Discovering the intricate mechanisms of memory maintenance, Tsokas et al. reveal that the interaction between KIBRA and PKMζ is critical for sustaining long-term potentiation and memory in the brain

Jun 27, 2024 · 39 followers View post →
Maitreya
@Mithreu · X

Synaptic modification by L-theanine, a natural constituent in green tea, rescues the impairment of hippocampal long-term potentiation and memory in [Alzheimer's disease] AD mice https://t.co/osQfLfqJHE

Jun 16, 2024 · 1 like · 1,259 followers View post →
Yuji Marutani | The Exiled Emperor
@YujiMarutani · X

Long Term Potentiation and Memory Formation, Animation https://t.co/Fz62xtR2T7 via @YouTube

Feb 4, 2024 · 1,570 followers View post →
Proteins InVivo InVitro
@BVpapers · X

BK channels sustain neuronal Ca2+ oscillations to support hippocampal long-term potentiation and memory formation: Mutations of large conductance Ca^(2+)- and voltage-activated K^(+) channels (BK) are associated with cognitive impairment. Here we report… https://t.co/PjbfNHEI6g https://t.co/Mw4BGYNnaI

Nov 22, 2023 · 43 followers View post →
Fez☯️
@Zenfrog4 · X

While it is true that overactive NMDA receptors can lead to excitation/misuse of calcium in the body. https://t.co/s3Q9ce32KJ Calcium influx through NMDAR remains essential for the various signaling pathways involved in synaptic plasticity, long-term potentiation, and memory.

Oct 23, 2023 · 3,219 followers View post →
W R
@rylan7 · X

Long Term Potentiation and #Memory Formation, Animation https://t.co/RfGixyikaB via @YouTube -- #brain

Apr 11, 2023 · 1,506 followers View post →
Nicole Laurent, LMHC
@KetoCounselor · X

While transient mitochondrial reactive oxygen species (ROS) production is beneficial for synaptic signaling, long-term potentiation, and memory-related mechanisms, mitochondrial dysfunction causes ROS overproduction and oxidative damage. (8/13)

Apr 9, 2023 · 5 likes · 9,127 followers View post →
Jack
@Jack75173493 · X

Long Term Potentiation and Memory Formation, Animation https://t.co/TJt2FKrofI

Feb 6, 2023 · 729 followers View post →
Mattias Michael
@michael_mattias · X

Topomax (it’s active ingredient) is a protein synthesis inhibitor that prevent long term potentiation and memory consolidation https://t.co/Bz9waijDwM

Sep 10, 2022 · 53 followers View post →
luca Leli.
@adamoprogresso · X

RT @adamoprogresso: Long-Term Potentiation and Memory | Physiological Reviews https://t.co/ypnIRSvuM9

Aug 9, 2022 · 3,323 followers View post →
luca Leli.
@adamoprogresso · X

Long-Term Potentiation and Memory | Physiological Reviews https://t.co/ypnIRSvuM9

Jul 9, 2022 · 3,323 followers View post →
luca Leli.
@adamoprogresso · X

Potenziamento e memoria a lungo termine | Recensioni fisiologiche https://t.co/ypnIRSvuM9

Jul 7, 2022 · 3,323 followers View post →
DebFOPA
@DebFOPA · X

RT @molpsychiatry: Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms inc…

Feb 24, 2022 · 2 shares · 1,354 followers View post →
molecularpsychiatry
@molpsychiatry · X

Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling. By Daniel G. Blackmore et al. @QldBrainInst #ultrasound #lifu #potentiation #memory #OpenAccess https://t.co/XFIspxF5zH https://t.co/LZmnaMgFKP

Feb 23, 2022 · 17 likes · 2 shares · 2,352 followers View post →
luca Leli.
@adamoprogresso · X

RT @adamoprogresso: Long-Term Potentiation and Memory | Physiological Reviews https://t.co/ZAv9ihyCL1

Dec 23, 2021 · 3,323 followers View post →
luca Leli.
@adamoprogresso · X

Long-Term Potentiation and Memory | Physiological Reviews https://t.co/ZAv9ihyCL1

Dec 20, 2021 · 3,323 followers View post →
luca Leli.
@adamoprogresso · X

Long-Term Potentiation and Memory | Physiological Reviews https://t.co/29V7bYYK6g

Dec 19, 2021 · 3,323 followers View post →
/r/Neuroscience
@neuroreddit · X

Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling https://t.co/Y6tisZKUJz

Jun 25, 2021 · 6 followers View post →
Documents Delivered, LLC
@DocsDel · X

A neuroligin-1-derived peptide stimulates phosphorylation of the NMDA receptor NR1 subunit and rescues MK-801-induced decrease in long-term potentiation and memory impairment https://t.co/heg5U9dzwL

Jun 8, 2021 · 178 followers View post →
Fred Meunier
@MeunierLab · X

RT @AustraliaGoetz: https://t.co/likPIz5ydS (Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through…

Jun 8, 2021 · 9 shares · 2,034 followers View post →
Agingdoc
@agingdoc1 · X

Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling https://t.co/zpExiZ01ux Gen audience summary No Breach Needed: Ultrasound Improves Memory in Mice https://t.co/m9Gvirqp8w

Jun 5, 2021 · 2 likes · 43,816 followers View post →
Paul McCullough
@ThePostsynaptic · X

Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling https://t.co/UlSfTbmdga https://t.co/OjyHKLOQQn

May 29, 2021 · 2,585 followers View post →
delladavid-lab.bsky.social
@DellaDavid_Lab · X

RT @AustraliaGoetz: https://t.co/likPIz5ydS (Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through…

May 28, 2021 · 9 shares · 783 followers View post →
SynapsePapers
@SynapsePapers · X

Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling https://t.co/RDSBx4MROw

May 27, 2021 · 472 followers View post →
Sandeep Arora
@LetDdiceFlyHigh · X

RT @FUSFoundation: New study just published in Molecular Psychiatry from @AustraliaGoetz and the team at the @QldBrainInst - "Low-intensity…

May 27, 2021 · 2 shares · 2,993 followers View post →
ANS Students Australasian Neuroscience Society
@ANS_Students · X

RT @QBI_papers: Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms includ…

May 27, 2021 · 1 share · 988 followers View post →
QBIpapers
@QBI_papers · X

Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling https://t.co/RqWebway8r

May 27, 2021 · 2 likes · 1 share · 299 followers View post →
Focused Ultrasound Foundation
@FUSFoundation · X

New study just published in Molecular Psychiatry from @AustraliaGoetz and the team at the @QldBrainInst - "Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling" https://t.co/S5Oq3Z9tEF

May 27, 2021 · 7 likes · 2 shares · 3,330 followers View post →
Sandeep Arora
@LetDdiceFlyHigh · X

RT @AustraliaGoetz: https://t.co/likPIz5ydS (Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through…

May 27, 2021 · 9 shares · 2,993 followers View post →
Ramón Martínez-Mármol
@marmol_dr · X

RT @AustraliaGoetz: https://t.co/likPIz5ydS (Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through…

May 27, 2021 · 9 shares · 838 followers View post →
Rinie Bajracharya
@rinie_baj · X

RT @AustraliaGoetz: https://t.co/likPIz5ydS (Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through…

May 27, 2021 · 9 shares · 419 followers View post →
Dr Liyu Chen
@stefcly · X

RT @AustraliaGoetz: https://t.co/likPIz5ydS (Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through…

May 27, 2021 · 9 shares · 389 followers View post →
Anggono Lab
@AnggonoLab · X

RT @AustraliaGoetz: https://t.co/likPIz5ydS (Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through…

May 27, 2021 · 9 shares · 823 followers View post →
Brett Collins
@brettcollins100 · X

RT @AustraliaGoetz: https://t.co/likPIz5ydS (Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through…

May 27, 2021 · 9 shares · 2,329 followers View post →
Peter Johnstone
@peterajohnstone · X

RT @AustraliaGoetz: https://t.co/likPIz5ydS (Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through…

May 26, 2021 · 9 shares · 103 followers View post →
Juergen Goetz
@AustraliaGoetz · X

https://t.co/likPIz5ydS (Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling - now online)

May 26, 2021 · 32 likes · 9 shares · 356 followers View post →
Charles Thomas Wild
@CharlesThomasW7 · X

Long Term Potentiation and Memory Formation https://t.co/WJQqPpnEIA (Google)

Apr 11, 2021 · 358 followers View post →
Joanna Poole
@Jopo_dr · X

They subserve long term potentiation and memory formation is dependent on their fission/fusion reactions. Meanwhile, mitochondria on different microtubules, can bump into each other laterally, for as little as a few seconds, and recharge enough mtDNA, respiratory enzymes, ADP

Sep 8, 2020 · 3 likes · 23,194 followers View post →
Русские летописи и кот Онфим
@letopisi_rus · X

Чтобы вести срач на должном уровне, прочел статью Transgenerational Rescue of a Genetic Defect in Long-Term Potentiation and Memory Formation by Juvenile Enrichment и обзор Epigenetic Influence of Social Experiences Across the Lifespan. Твитор образовательный

Jul 16, 2020 · 59 likes · 31,377 followers View post →
NootropicReddit
@NootropicReddit · X

Erythropoietin Enhances Hippocampal Long-Term Potentiation and Memory via /r/Nootropics https://t.co/87ppVHYxVU

May 27, 2020 · 792 followers View post →
Learning and Teaching
@DerbyUniLT · X

A video our team have created about Long Term Potentiation and Memory - Want to have something similar created for your course? Why not contact TEL and use a Digital Media Producer. https://t.co/NZllejbEuX

Jan 23, 2020 · 1,021 followers View post →
luca Leli.
@adamoprogresso · X

RT @adamoprogresso: Long-Term Potentiation and Memory | Physiological Reviews https://t.co/nXLkCEeAoq

Nov 13, 2019 · 3,323 followers View post →
luca Leli.
@adamoprogresso · X

Long-Term Potentiation and Memory | Physiological Reviews https://t.co/nXLkCEeAoq

Nov 13, 2019 · 3,323 followers View post →
luca Leli.
@adamoprogresso · X

RT @adamoprogresso: Long-Term Potentiation and Memory | Physiological Reviews https://t.co/2jUCXnejVh

Nov 12, 2019 · 3,323 followers View post →
luca Leli.
@adamoprogresso · X

RT @adamoprogresso: https://t.co/2jUCXnejVh https://t.co/2jUCXnejVh

Nov 12, 2019 · 3,323 followers View post →
luca Leli.
@adamoprogresso · X

Long-Term Potentiation and Memory | Physiological Reviews https://t.co/2jUCXnejVh

Nov 11, 2019 · 3,323 followers View post →
luca Leli.
@adamoprogresso · X

RT @adamoprogresso: Potenziamento e memoria a lungo termine | Recensioni fisiologiche https://t.co/2jUCXnejVh

Nov 11, 2019 · 3,323 followers View post →
luca Leli.
@adamoprogresso · X

Potenziamento e memoria a lungo termine | Recensioni fisiologiche https://t.co/2jUCXnejVh

Nov 10, 2019 · 3,323 followers View post →
luca Leli.
@adamoprogresso · X

Long-Term Potentiation and Memory | Physiological Reviews https://t.co/7w4XT8mZJ8

Oct 27, 2019 · 3,323 followers View post →
SynapsePapers
@SynapsePapers · X

Serotonin type 6 receptor antagonist attenuates the impairment of long-term potentiation and memory induced by Abeta. https://t.co/lzDcAo2CJw

Feb 9, 2019 · 472 followers View post →