PubHawk
J Biol Chem March 2004 PMID 14729660

mRNA is an endogenous ligand for Toll-like receptor 3.

Katalin Karikó, Houping Ni, John Capodici, Marc Lamphier, Drew Weissman

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Mentions

42
Peak: 9 in Aug 2021
across 5 sources since Jan 2021

Extended reach

232,646
potential audience

Total likes

213

Video views

2,108

Mentions per month

Jan 2021 – May 2024

Where it's discussed

  • X / Twitter27 posts
  • News8 articles
  • Blogs3 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

Discussions reflect skepticism about the relevance of mRNA's role as an endogenous ligand, emphasizing concerns over vaccine efficiency, side effects like thrombosis, and non-specific immune activation, with phrases like 'very inefficient' and 'poor side effects' indicating critical tones that influence the overall assessment.

AgreementLow agreement

Most posts express skepticism or highlight limitations of the findings, pointing to inefficiency and non-specific immune responses.

InterestModerate interest

Posts show moderate curiosity, mainly questioning vaccine efficacy and mechanisms rather than deeply exploring the scientific details.

EngagementModerate engagement

Several posts reference the technology and potential side effects, indicating some degree of engagement, though not highly detailed.

ImpactNeutral impact

The discussions suggest that while the topic raises important concerns, the overall perceived impact on public health policies remains uncertain.

Abstract in brief

  • The study shows that mRNA and other RNA sources released from or associated with damaged or necrotic cells can activate Toll-like receptor 3 (TLR3), a key receptor in the innate immune system that responds to viral double-stranded RNA.
  • Laboratory experiments using human cell lines demonstrated that both synthetic and natural RNA can trigger TLR3, leading to immune responses such as cytokine production and cell activation, which involve signaling pathways like NF-kappaB and tyrosine phosphorylation.
  • The findings suggest that endogenous RNA from damaged tissues may serve as a natural ligand for TLR3, playing a significant role in initiating or modulating immune responses during tissue injury or infection.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Semih Tareen
@virusfantom · X

Sep 14, 2021 · 111 likes · 5 shares · 149,903 followers View post →
WB
@Wb29304326Wb · X

TLR-3は自然免疫のスイッチのひとつであるが、ウイルス由来のdsRNAだけでなく、内因性ｍRNAでもTLR-3の活性化因子として作用することがある。 https://t.co/2wATWWEJSu

Feb 24, 2023 · 13 likes · 3 shares · 12,781 followers View post →
ASBMB
@ASBMB · X

The @jbiolchem paper "mRNA Is an Endogenous Ligand for Toll-like Receptor 3*" by Kariko et al. was referenced in today's announcement of the 2023 @NobelPrize in Physiology or Medicine! ➡️Read the paper here: https://t.co/FKGkAHRoUm. ➡️Announcement: https://t.co/6MtbtbvQnW. https://t.co/DnsKtn0TbM

Oct 2, 2023 · 5 likes · 3 shares · 27,261 followers View post →
shambo guha roy
@ChestradRoy · X

@sankha_shubhra This paper was published almost 2 decades before covid, opening up a while new technology. Most people would call it ‘groundbreaking’. Anyway, you can blame alexander fleming for antibiotic resistance, surely! https://t.co/VpTr1by72V

Oct 2, 2023 · 5 likes · 1 share · 1,595 followers View post →
DarvinEmmi
@DarvinEmmi · X

@okBilmi10311253 @armanac05 @DrSarperSaglam 2004 yılında Karikó ve Weissman çok önemli bir buluş yaptılar: mRNA’ya karşı hücre içi TLR3 direncini keşfettiler. Bu direncin önüne geçebilmek mRNA aşılarının başarısı için şarttı. https://t.co/klPAzbFCNA

Aug 6, 2022 · 2 likes · 413 followers View post →
Kuniko Inoue
@InoueKuniko · X

@zerohedge It only approved that the mRNA vaccine is very inefficient. Its anti-viral effects maybe not specific. Long chain of mRNA can trigger Toll-like receptor mediated nonspecific immune response and poor side effects such as thrombosis and cardiac infection https://t.co/Kx6CRBMcJB

Aug 7, 2021 · 1 like · 62 followers View post →

All mentions

periophthalmus
@zet_mood · X

@Ihamessou1 @PBertaGard @OPECST_ 2/vous vouliez des élément de preuve qui confirme que la pseudoU permet une bonne traduction alors voici quelques exemples d'etudes: https://t.co/y9GzdLO19r https://t.co/NYpfPP9cyF https://t.co/UeI36f5hDR

May 31, 2024 · 132 followers View post →
Noisy Nanny.
@NannyNoisy · X

mRNA Is an Endogenous Ligand for Toll-like Receptor 3* - Journal of Biological Chemistry https://t.co/kmZfEpxnAn

Jan 3, 2024 · 381 followers View post →
Marissa Locke Rottinghaus
@locke_marissa · X

RT @ASBMB: The @jbiolchem paper "mRNA Is an Endogenous Ligand for Toll-like Receptor 3*" by Kariko et al. was referenced in today's announc…

Oct 4, 2023 · 3 shares · 607 followers View post →
Journal of Biological Chemistry
@jbiolchem · X

RT @ASBMB: The @jbiolchem paper "mRNA Is an Endogenous Ligand for Toll-like Receptor 3*" by Kariko et al. was referenced in today's announc…

Oct 4, 2023 · 3 shares · 21,263 followers View post →
qupath
@quantweet88 · X

RT @virusfantom:

Oct 3, 2023 · 5 shares · 57 followers View post →
Zeliha Karadal
@ZelihaKaradal · X

RT @virusfantom:

Oct 3, 2023 · 5 shares · 5,784 followers View post →
N O M O S 09
@NTugbay · X

RT @virusfantom:

Oct 3, 2023 · 5 shares · 2,012 followers View post →
Narasimha Reddy D
@DonthiNreddy · X

RT @ChestradRoy: @sankha_shubhra This paper was published almost 2 decades before covid, opening up a while new technology. Most people wou…

Oct 3, 2023 · 1 share · 787 followers View post →
ASBMB
@ASBMB · X

The @jbiolchem paper "mRNA Is an Endogenous Ligand for Toll-like Receptor 3*" by Kariko et al. was referenced in today's announcement of the 2023 @NobelPrize in Physiology or Medicine! ➡️Read the paper here: https://t.co/FKGkAHRoUm. ➡️Announcement: https://t.co/6MtbtbvQnW. https://t.co/DnsKtn0TbM

Oct 2, 2023 · 5 likes · 3 shares · 27,261 followers View post →
shambo guha roy
@ChestradRoy · X

@sankha_shubhra This paper was published almost 2 decades before covid, opening up a while new technology. Most people would call it ‘groundbreaking’. Anyway, you can blame alexander fleming for antibiotic resistance, surely! https://t.co/VpTr1by72V

Oct 2, 2023 · 5 likes · 1 share · 1,595 followers View post →
Mr.S
@MrS89715471 · X

RT @wb29304326: TLR-3は自然免疫のスイッチのひとつであるが、ウイルス由来のdsRNAだけでなく、内因性ｍRNAでもTLR-3の活性化因子として作用することがある。 https://t.co/2wATWWEJSu

Feb 24, 2023 · 3 shares · 725 followers View post →
llontyanne
@iron_tyanne · X

RT @wb29304326: TLR-3は自然免疫のスイッチのひとつであるが、ウイルス由来のdsRNAだけでなく、内因性ｍRNAでもTLR-3の活性化因子として作用することがある。 https://t.co/2wATWWEJSu

Feb 24, 2023 · 3 shares · 116 followers View post →
_24_com
@_24_com · X

RT @wb29304326: TLR-3は自然免疫のスイッチのひとつであるが、ウイルス由来のdsRNAだけでなく、内因性ｍRNAでもTLR-3の活性化因子として作用することがある。 https://t.co/2wATWWEJSu

Feb 24, 2023 · 3 shares · 1,482 followers View post →
WB
@Wb29304326Wb · X

TLR-3は自然免疫のスイッチのひとつであるが、ウイルス由来のdsRNAだけでなく、内因性ｍRNAでもTLR-3の活性化因子として作用することがある。 https://t.co/2wATWWEJSu

Feb 24, 2023 · 13 likes · 3 shares · 12,781 followers View post →
Darwin
@DarwinEmmiYedek · X

@YlmazKu19119629 2004 yılında Karikó ve Weissman çok önemli bir buluş yaptılar: mRNA’ya karşı hücre içi TLR3 direncini keşfettiler. Bu direncin önüne geçebilmek mRNA aşılarının başarısı için şarttı. https://t.co/0y68R7013G https://t.co/qu0ULMwUhd

Aug 13, 2022 · 257 followers View post →
DarvinEmmi
@DarvinEmmi · X

@okBilmi10311253 @armanac05 @DrSarperSaglam 2004 yılında Karikó ve Weissman çok önemli bir buluş yaptılar: mRNA’ya karşı hücre içi TLR3 direncini keşfettiler. Bu direncin önüne geçebilmek mRNA aşılarının başarısı için şarttı. https://t.co/klPAzbFCNA

Aug 6, 2022 · 2 likes · 413 followers View post →
Semah Tan
@Semah40268287 · X

RT @virusfantom:

Sep 16, 2021 · 5 shares · 334 followers View post →
Semih Tareen
@virusfantom · X

Sep 14, 2021 · 111 likes · 5 shares · 149,903 followers View post →
Kuniko Inoue
@InoueKuniko · X

@business @BW In human vaccine history, is any vaccine have to give 3 shots in 1 year? Any long chain of mRNA nucleic acid such as poly I:C can trigger nonspecific immune response. It also can trigger thrombosis and myocarditis via TLR receptor as mRNA vaccine did. https://t.co/Kx6CRBMcJB

Aug 14, 2021 · 1 like · 62 followers View post →
Kuniko Inoue
@InoueKuniko · X

@WSJ In vaccine history, Is any vaccine need 3 shots in 1 year? It only confirmed that mRNA vaccine is not efficient and target specific. Might be transiently active non-specific immune response by long mRNA chain no matter what it is. Need more research on it https://t.co/Kx6CRBMcJB

Aug 14, 2021 · 62 followers View post →
Kuniko Inoue
@InoueKuniko · X

@zerohedge What's the real target of mRNA vaccine? Any mRNA can trigger nonspecific immune response in a short period via Toll-like receptor. That's why Moderna want to give 3rd shot? Long chain of mRNA also can trigger thrombosis and myocarditis via TLR receptor. https://t.co/Kx6CRBMcJB

Aug 12, 2021 · 62 followers View post →
Kuniko Inoue
@InoueKuniko · X

@asymmetricalpha What's the real effect of mRNA vaccine? Any mRNA can trigger nonspecific immune response in a short period via Toll-like receptor. That's why Moderna want to give 3rd shot? Long chain of mRNA also can trigger thrombosis and myocarditis via TLR receptor. https://t.co/Kx6CRBMcJB

Aug 12, 2021 · 62 followers View post →
Kuniko Inoue
@InoueKuniko · X

@zerohedge All mRNA vaccine may not generate COVID specific antibody as its COVID S-protein mRNA has to go into human cells first, using human cell machinery to produce spike protein, and secreted out to be recognized by APC cells to active immune response. However,https://t.co/Kx6CRBMcJB

Aug 12, 2021 · 62 followers View post →
Kuniko Inoue
@InoueKuniko · X

@SwingTrader1114 @zerohedge Think about it, Which vaccine do we need to inject 3 times in one year? mRNA is long chain of nucleic acid, can trigger Toll-like receptor mediated nonspecific immune response and poor side effects such as thrombosis and cardiac infection https://t.co/Kx6CRBMcJB

Aug 12, 2021 · 62 followers View post →
Allisa Kennedy
@AllisaBlue · X

RT @InoueKuniko: @zerohedge It only approved that the mRNA vaccine is very inefficient. Its anti-viral effects maybe not specific. Long cha…

Aug 7, 2021 · 1 share · 4,053 followers View post →
Kuniko Inoue
@InoueKuniko · X

@zerohedge It only approved that the mRNA vaccine is very inefficient. Its anti-viral effects maybe not specific. Long chain of mRNA can trigger Toll-like receptor mediated nonspecific immune response and poor side effects such as thrombosis and cardiac infection https://t.co/Kx6CRBMcJB

Aug 7, 2021 · 1 like · 62 followers View post →
Kuniko Inoue
@InoueKuniko · X

@zerohedge It only approved that the mRNA vaccine is very inefficient. Its anti-viral effects maybe not specific. Long chain of mRNA can trigger Toll-like receptor mediated nonspecific immune response and potential thrombosis and myocarditis https://t.co/Kx6CRBMcJB https://t.co/jBAYpXyTHS

Aug 7, 2021 · 1 share · 62 followers View post →