Accumulation of advanced glycation end products as a molecular mechanism for aging as a risk factor in osteoarthritis.

Jeroen DeGroot, Nicole Verzijl, Marion J G Wenting-van Wijk, Kim M G Jacobs, Benno Van El, Peter M Van Roermund, Ruud A Bank, Johannes W J Bijlsma, Johan M TeKoppele, Floris P J G Lafeber

April 2004

Synopsis of Social media discussions

The social discussions focus on mechanisms such as carbohydrate intake leading to AGE accumulation, with phrases like 'AGEs from injected sugar' suggesting curiosity about biochemical pathways. The tone is somewhat informal and exploratory, reflecting interest but not full consensus or deep engagement.

A
Agreement
 Neither agree nor disagree

Most discussions seem neutral or tentative about the study's conclusions, with limited clear support or disagreement.

I
Interest
 Moderate level of interest

Participants show some curiosity, especially regarding the connection between diet, AGEs, and osteoarthritis.

E
Engagement
 Moderate level of engagement

Comments indicate a moderate level of detailed discussion, referencing mechanisms like carbohydrate intake and glycation processes.

I
Impact
 Neutral impact

The discussions hint at potential significance but lack strong emphasis on immediate real-world implications.

Social Mentions

YouTube

2 Videos

Twitter

1 Posts

Metrics

Video Views

113

Total Likes

2

Extended Reach

218

Social Features

3

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

The Connection Between Diabetes and Dietary Guidelines

The Connection Between Diabetes and Dietary Guidelines

This presentation explores the clinical implications of diabetes, including how dietary guidelines have evolved. It examines conflicts of interest among health organizations and irregularities in the review processes for saturated fat recommendations.

Dynamic Physio Therapy

October 5, 2023

81 views

Exploring the Clinical Links Between Diabetes and Osteoarthritis

Exploring the Clinical Links Between Diabetes and Osteoarthritis

This video examines the clinical implications of diabetes in relation to osteoarthritis. It delves into the connection between type 2 diabetes and its impact on joint health, highlighting the role of advanced glycation end products and other molecular mechanisms.

Dynamic Physio Therapy

October 5, 2023

32 views

  • dfr
    @_deepfire (Twitter)

    RT @PubMedReader: Advanced Glycation End Products frm injected sugar⇧#OA.https://t.co/BjJd1h3VFs Carbs ⇨AGEs https://t.co/dsR90htMkc Theref…
    view full post

    January 16, 2024

    1

Abstract Synopsis

  • The study suggests that the buildup of advanced glycation end products (AGEs), which increase with age, can weaken cartilage and make osteoarthritis (OA) worse.
  • Researchers increased AGE levels in young dogs' knee cartilage using ribose injections and found these dogs developed more severe OA after ligament injury compared to dogs with normal AGE levels.
  • The results indicate that higher AGE levels impair the cartilage’s ability to repair itself, which may explain how aging contributes to osteoarthritis development.]