N Engl J Med June 2004 PMID 15215484

Myostatin mutation associated with gross muscle hypertrophy in a child.

Markus Schuelke, Kathryn R Wagner, Leslie E Stolz, Christoph Hübner, Thomas Riebel, Wolfgang Kömen, Thomas Braun, James F Tobin, Se-Jin Lee

Mentions

36
Peak: 3 in Feb 2021
across 6 sources since May 2017

Extended reach

1,502,537
potential audience

Total likes

32,581

Video views

1,495,944

Mentions per month

May 2017 – Aug 2025

Where it's discussed

  • News15 articles
  • Blogs9 articles
  • X / Twitter5 posts
  • YouTube3 videos
  • Facebook2 posts
  • Reddit2 posts

AI synopsis

What people are saying

The discussions reflect a generally positive and intrigued attitude, with comments like 'Superman is real' and mentions of the child's capabilities, indicating interest and engagement. The tone combines casual amazement with scientific curiosity, emphasizing the mutation's implications for therapy and understanding muscle development, which supports the high impact score.

AgreementModerate agreement

Most discussions recognize the significance of the research, supporting its implications for muscle growth and potential therapies.

InterestModerate interest

Participants show moderate curiosity, with remarks like noting the child's ability to lift weights and recognizing the novelty of the mutation.

EngagementModerate engagement

Posts delve into the biology of the mutation, such as comments on muscle regulation and the case's implications for understanding muscle disorders.

ImpactHigh impact

The discussions highlight the potential influence of this research on medical approaches to muscle wasting and genetic research.

Abstract in brief

  • The text discusses a case involving a child who has a mutation in the myostatin gene, which leads to significantly increased muscle growth, known as hypertrophy.
  • Myostatin is a protein that normally helps regulate muscle growth by limiting muscle size, so a mutation can cause muscles to grow abnormally large.
  • This case highlights the potential genetic factors behind muscle development and could have implications for understanding muscle disorders or developing therapies for muscle growth.

Top posts

Most liked on X and Bluesky
Knowmad Institut
@KnowmadInstitut · X

- Schuelke, M., Wagner, K. R., Stolz, L. E., Hübner, C., Riebel, T., Kömen, W., … Lee, S.-J. (2004). Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child. New England Journal of Medicine, 350(26), 2682–2688. https://t.co/N8ISYrDsVQ

Feb 10, 2021 · 1 like · 725 followers View post →
Knowmad Institut
@KnowmadInstitut · X

Myostatin mutation associated with gross muscle hypertrophy in a child. The authors explain that muscle wasting and weakness are some of the most common inherited and acquired disorders and include muscular dystrophies, cachexia, and age-related atrophy.

Feb 10, 2021 · 1 like · 725 followers View post →
UROŠ
@UrosMikolic · X

Superman is real. . Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child | NEJM https://t.co/2YqnD6vHnW https://t.co/6q6nTkwIPK

Feb 10, 2021 · 3,224 followers View post →
Mahek Shah, MD
@Cardiobro · X

At 4.5 yrs of age, he can hold two 3-kg dumbbells in horizontal suspension with arms extended

Jan 2, 2024 · 1,826 followers View post →

All mentions

Mahek Shah, MD
@Cardiobro · X

At 4.5 yrs of age, he can hold two 3-kg dumbbells in horizontal suspension with arms extended

Jan 2, 2024 · 1,826 followers View post →
UROŠ
@UrosMikolic · X

Superman is real. . Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child | NEJM https://t.co/2YqnD6vHnW https://t.co/6q6nTkwIPK

Feb 10, 2021 · 3,224 followers View post →
Knowmad Institut
@KnowmadInstitut · X

- Schuelke, M., Wagner, K. R., Stolz, L. E., Hübner, C., Riebel, T., Kömen, W., … Lee, S.-J. (2004). Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child. New England Journal of Medicine, 350(26), 2682–2688. https://t.co/N8ISYrDsVQ

Feb 10, 2021 · 1 like · 725 followers View post →
Knowmad Institut
@KnowmadInstitut · X

Myostatin mutation associated with gross muscle hypertrophy in a child. The authors explain that muscle wasting and weakness are some of the most common inherited and acquired disorders and include muscular dystrophies, cachexia, and age-related atrophy.

Feb 10, 2021 · 1 like · 725 followers View post →
Chris
@chriscrubs · X

Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child | NEJM https://t.co/p8uRVPhtGt

Dec 29, 2020 · 94 followers View post →