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The conversations consistently show enthusiasm for metabolic flexibility, such as posts describing how fasting, strength training, and dietary adjustments can enhance it, while references to recent research, genetic factors, and practical tips demonstrate a high level of engagement and belief in its significance for health. Words like 'game-changer' and descriptions of interventions illustrate the perceived profound influence of understanding and optimizing this metabolic trait.
Most discussions support metabolic flexibility as a key factor in health, emphasizing its benefits and potential for reversal.
The discussions reflect high curiosity with many posts sharing research, practical strategies, and examples, indicating strong interest.
Posts delve into mechanisms (like AMPK, PPARs), share personal experiences, and discuss recent studies, showing deep engagement.
Many discussions highlight the potential of improving metabolic flexibility to reverse disease markers and promote longevity, indicating a notable impact.
Dr. Oz: “Buy this miracle cure!” RFK Jr.: “The cure is worse than the disease!” Casey Means: “Actually, the cure is metabolic flexibility and this $299 sensor patch.”
Dr. Oz: “Buy this miracle cure!” RFK Jr.: “The cure is worse than the disease!” Casey Means: “Actually, the cure is metabolic flexibility and this $299 sensor patch.”
chemical messenger that recruits other immune defenses. The studies showed that metabolic flexibility, not target recognition, foretells how long the immune cells will keep fighting. Among the populations of tumor-infiltrating T-cells that were so diverse, one stood out as extraordinary: a subset of
Hidden Signs of Poor Metabolic Flexibility. 1) Getting shaky when hungry 2) Difficulty fasting 3) Huge after-meal crash 4) Needing snacks to function 5) Fog after carbs 6) Hunger every 2–3 hours Your metabolism can’t switch fuels.
Fat-adapted=your metabolism has switched from “carb-dependent” to “fat efficient” When you’re fat-adapted you get: steadier energy fewer cravings better focus improved metabolic flexibility easier fat loss The body stops begging for snacks & starts running like it was designed to
A filler episode in between Metabolic Flexibility Part II in the pipeline: Insulin Read it here: https://t.co/GKXgZCpVyz https://t.co/12b1Z8LAJF https://t.co/FMw5y0aike
Nutrient timing highlights the importance of protein and carbohydrate intake around exercise sessions to enhance body composition. This video explores recent research on post-exercise nutrition and its impact on muscle…
Nutrient timing focuses on consuming protein and carbohydrates around exercise sessions to enhance body composition. This video reviews evidence-based nutritional recommendations for post-exercise adaptations, providing…
@bcE6CHd5NY58549 @YouTube The interplay between energy sensing like AMPK and transcriptional control via PPARs dictates long-term metabolic flexibility.
Improves metabolic flexibility ▬كؤبؤن▬كود▬خصم▬ ⎐المطار⎐ ⊵M2⊴
Improves metabolic flexibility كؤد خصم ▬لىفل▬شوز▬لىفىل▬ ⊵SAA⊴
chemical messenger that recruits other immune defenses. The studies showed that metabolic flexibility, not target recognition, foretells how long the immune cells will keep fighting. Among the populations of tumor-infiltrating T-cells that were so diverse, one stood out as extraordinary: a subset of
RT @Diet0Nutrition: @wideawake_media Fasting fundamentally changes metabolism. It triggers autophagy, cellular cleanup. Nobel Prize-winning…
Most protocols assume a baseline state you don't have. - Keto assumes metabolic flexibility. - IF assumes low cortisol. - HIIT assumes recovery capacity. The protocol works in the right context. You're operating in the wrong one.
@thegarybrecka The underrated benefit of strength training is how fast it stabilizes the glucose–cortisol system. More muscle = • better glucose clearance • lower baseline cortisol • stronger mitochondrial output • more metabolic flexibility • faster recovery Most people
@wideawake_media Fasting fundamentally changes metabolism. It triggers autophagy, cellular cleanup. Nobel Prize-winning research confirmed this mechanism. Studies published in Cell Metabolism show improved insulin sensitivity. The metabolic flexibility is staggering. This threatens a $4.1
Improves metabolic flexibility ▬كؤبؤن▬كود▬خصم▬ ⎐دبدوب⎐ ⊵DD11⊴
RT @shashiiyengar: Hidden Signs of Poor Metabolic Flexibility. 1) Getting shaky when hungry 2) Difficulty fasting 3) Huge after-meal crash…
RT @shashiiyengar: Hidden Signs of Poor Metabolic Flexibility. 1) Getting shaky when hungry 2) Difficulty fasting 3) Huge after-meal crash…
RT @NathanNikoloff: @RobLipsett @GodBTCFamily I think your intuition was serving you well. Below are some summaries of the SIGNIFICANT impr…
RT @shashiiyengar: Hidden Signs of Poor Metabolic Flexibility. 1) Getting shaky when hungry 2) Difficulty fasting 3) Huge after-meal crash…
RT @shashiiyengar: Hidden Signs of Poor Metabolic Flexibility. 1) Getting shaky when hungry 2) Difficulty fasting 3) Huge after-meal crash…
Hidden Signs of Poor Metabolic Flexibility. 1) Getting shaky when hungry 2) Difficulty fasting 3) Huge after-meal crash 4) Needing snacks to function 5) Fog after carbs 6) Hunger every 2–3 hours Your metabolism can’t switch fuels.
@mikeoniron Agreed. The Twinkie Thingie will even restore metabolic flexibility.
Joe's raw share - from bell-ringing "win" to stage 4 return, then reclaiming life via water fasting (autophagy trigger), keto-vegan (GKI optimization), and lab-guided nutrients - highlights metabolic flexibility's role in recurrence fights. Key supportive angles: • Fasting
Ancient healers knew metabolic flexibility was key to lasting change. Adaptogens like Rhodiola guide this recalibration, supporting the body's wisdom as it finds its new balance beyond mere calorie math. https://t.co/1q7C9lOYKT
Low DHT may reduce: • Muscle-building signals • Drive and motivation • Mitochondrial output • Metabolic flexibility Rising SHBG reduces the availability of active hormones, leading to less free DHT for tissues that need it.
@maxmarchione Watch out you will make the ketos and carnivores real real big mad if you point out the fact that exercise paired with a very low fat diet and really high carb consumption, especially in the form of whole fruit, protein equated, can actually rapidly restore metabolic flexibility.
RT @hormonedietdoc: Fat-adapted=your metabolism has switched from “carb-dependent” to “fat efficient” When you’re fat-adapted you get: stea…
@wilsonhlthcoach People are conditioned to fear Cholesterol while completely ignoring the markers that actually predict metabolic collapse: • Insulin • Inflammation • Visceral fat • Triglyceride ratio • Mitochondria function • Liver status • Metabolic flexibility A person can be
@PGC1a_RB That will be in part II of this one https://t.co/2dlo1dVFYp
“Human infants are born in physiological ketosis, demonstrating that metabolic flexibility — the ability to seamlessly use both glucose and ketones — is our default metabolic state from day one.” #ketosis #nutrition https://t.co/ZcIHBjkWqM
@siimland Amazing how tweaking individual amino acids can shift whole-body physiology. There’s also growing work on how different amino acid profiles influence metabolic flexibility and aging biology. Feels like an area that’s going to expand quickly.
✨ Metabolic flexibility is the secret your body needs in midlife. It’s your body’s ability to switch between burning carbs and fat. When it’s low, you get stubborn weight, crashes and poor sleep. Episode 1 of The Reset Lab Podcast explains why + how to reset it.
@maxmarchione This is spot on. I truly hope the carb-fearing propaganda will stop soon. Our bodies need metabolic flexibility, and carbs aren’t the enemy.
Improves metabolic flexibility ▬كؤبؤن▬كود▬خصم▬ ⎐المطار⎐ ⊵M2⊴
Longevity isn’t just about adding years at the end of life. It’s also about adding life inside every year. If you focus on improving: •Mitochondria •Muscle mass •Metabolic flexibility •Mental clarity •Emotional stability You don’t just extend lifespan, you transform the
Real energy isn’t just from carbs or fats—it’s from your body’s ability to switch between them! That’s called metabolic flexibility—and it’s the key to all-day energy. Our latest blog explains: https://t.co/UWKifAA8xJ #MetabolicHealth #Energy #Nutrition https://t.co/Lp20xVnHZw
@maxmarchione Crazy how eating like a human instead of a hashtag diet can fix the thing the hashtag diet caused. Metabolic flexibility really just means “remembering how to use both gas and electric.”
#BrownAdiposeTissue (BAT) plays a role in #thermogenesis & energy homeostasis. This study shows how signals from the #SuprachiasmaticNucleus coordinate metabolic flexibility of BAT, via an ADRB3-S100B signaling axis, with therapeutic implications @plosbiology.org
7/7 Huge congrats to Yan, Liu, and team for nailing the HNF4A-AS1 axis!
Fat-adapted=your metabolism has switched from “carb-dependent” to “fat efficient” When you’re fat-adapted you get: steadier energy fewer cravings better focus improved metabolic flexibility easier fat loss The body stops begging for snacks & starts running like it was designed to
@begottensun This is the kind of outcome that changes lives. Coming off insulin and metformin in 30 days through diet alone is powerful evidence of metabolic flexibility. The nuance is that 5.3 MMOLs is excellent control, but blood pressure variability under stress shows the nervous system
RT @hormonedietdoc: Most people have never felt what true metabolic flexibility feels like A short period in ketosis can sharpen focus, st…
New research from Yale's #MuschenLab uncovers previously unseen MYC/BCL6-driven cell-state cycles in B-ALL. These switches between quiet and fast-growing states fuel metabolic flexibility, drug resistance & #leukemia-initiating capacity. #ASH25 @yale-hematology.bsky.social
@oldglstuf @ItIsMikeFitz I do now,after carnivore & I don't exercise that length of time.I burn fat,as well as carbs,don't gain in weight & my last bloods came back satisfactory. Important thing is to achieve metabolic flexibility.I am healthier since reintroducing carbs & fiber
Timing your fasting matters. Your metabolism changes across the day; circadian rhythms shape insulin and fat use. Fasting earlier and overnight supports metabolic flexibility instead of stress. I explain more in Episode 1 of the Reset Lab Podcast. Link in bio. https://t.co/057CNbeYw0
@CoachDanGo The biggest health lesson of 2025: “Metabolic flexibility” isn’t a nice-to-have — it’s the new baseline for survival in a world that keeps trying to make you insulin-resistant. Specifics that actually moved the needle this year: 1. Glucose is the smoke, not the fire. Watching
@Brady_H next week: scientists discover walking a dog is associated with greater metabolic flexibility
@jane7vale @newstart_2024 You should follow @drcourtneyhunt on IG. She teaches metabolic flexibility and how to get into a state of ketosis, fasting, and sunlight. Check her out. Best of luck.
Metabolic Flexibility is the 1 thing that allows us to be fat burning machines. If you’re metabolically flexible (~90% are not) your body can switch from burning Carbs/Sugars -> Fat. Most can achieve this by only eating Meat, Fruits, and Vegetables. Simple & Difficult Strategy
RT @YaleCancer: New research from @MuschenLab uncovers previously unseen MYC/BCL6-driven cell-state cycles in B-ALL. These switches between…
RT @YaleCancer: New research from @MuschenLab uncovers previously unseen MYC/BCL6-driven cell-state cycles in B-ALL. These switches between…
New research from @MuschenLab uncovers previously unseen MYC/BCL6-driven cell-state cycles in B-ALL. These switches between quiet and fast-growing states fuel metabolic flexibility, drug resistance & #leukemia-initiating capacity. #ASH25 @SmilowCancer @YaleHematology https://t.co/d80jdS5IYw
RT @SusannaSberg1: We fear hunger. Every small rise in appetite feels like an emergency. But gentle hunger is key to rebuilding metabolic f…
RT @WongEXE___: A filler episode in between Metabolic Flexibility Part II in the pipeline: Insulin Read it here: https://t.co/GKXgZCpVyz…
@iherbivore @CaryKelly11 Fat Adapted Vs Carb Dependent Was starting model. Then I experimented with Keto for e.g which meant learning about that and then I experimented with carnivore. Training was vary basic to begin with until looking then towards metabolic conditioning. Metabolic flexibility
@cryptokyle_33 @ZKForTre HRV is useful, yet it reflects only one branch of the system. A more adaptive approach is to combine HRV with measures of metabolic flexibility such as lactate curves, VO2 kinetics, and fasting to feeding glucose responses. These track the capacity of mitochondria to shift fuels
@ZKForTre HRV provides a practical, measurable proxy for systemic mitochondrial efficiency. High HRV reflects strong vagal tone, metabolic flexibility, and energy turnover, linking autonomic output to mitochondrial function. It’s non-invasive and accessible for almost anyone
@KetoCounselor Hi Nicole, good morning. I don’t think either of us wants a battle. I really do think you’re among the people helping move this field forward. To add context to what I meant: the mechanisms I mentioned, like network switching, metabolic flexibility, excitability trade-offs, show
A filler episode in between Metabolic Flexibility Part II in the pipeline: Insulin Read it here: https://t.co/GKXgZCpVyz https://t.co/12b1Z8LAJF https://t.co/FMw5y0aike
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
@AtlasSimian @bitcoinand_beef @DrJackKruse Peptides like MOTS-c directly influence mitochondrial function and metabolic flexibility, which are foundational to cellular resilience and broader health discussions.
Menopause hitting hard? Declining estrogen tanks metabolic flexibility, spiking visceral fat & muscle loss. Breath tech reveals if you're burning fat or carbs—empower for better energy, recovery & lean gains #Menopause #Metabolism #Lumen #WomensHealth #FitnessOver40 #MusclePreservation #Biohacking
Menopause hitting hard? Declining estrogen tanks metabolic flexibility, spiking visceral fat & muscle loss. Lumen's breath tech reveals if you're burning fat or carbs—empower your tweaks for better energy, recovery & lean gains (2-4kg in 12-24mo!). Game-changer for midlife women.
@peptidewebmd @Dr_Biohacker MOTS-c's impact on mitochondrial health in skeletal muscle is key. It helps optimize energy utilization, making those walks even more effective for metabolic flexibility.
@KetoCounselor Keto can help some patients with high excitability, but the studies are small and mechanistically narrow. Stabilizing one circuit can come at the cost of reduced metabolic flexibility and altered network switching elsewhere. What we eat profoundly shapes our physiology and
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
Ketosis pairs with this process. As glycogen drops, your body shifts to burning fat for fuel, which stabilizes energy and lowers inflammation even further. The combination of autophagy + ketosis is a powerful reset for gut health, metabolic flexibility, and overall recovery.
EverGen Longevity Insight: OMAD & Metabolic Flexibility OMAD isn’t about “boosting metabolism.” It supports lower insulin, lighter digestion, and more time in fat-burning and repair. For many, that means steadier energy and stronger metabolic flexibility. #EverGenLongevity #OMAD https://t.co/KoVekQTll9
@mattstaton @hubermanlab MOTS-C often modulates AMPK pathways for metabolic flexibility, while SS-31 directly supports mitochondrial membrane integrity and ATP production. Distinct but complementary mitochondrial targets.
2. Strategic Fasting: Integrate periods of intentional caloric restriction to give your digestive system rest, enhance metabolic flexibility, and stabilize energy levels.
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
@peptidewebmd @Rainmaker1973 MOTS-c's impact on mitochondrial function and metabolic flexibility is a core mechanism behind its influence on sustained energy and vigor. It's a fascinating link.
@DerSolberg @BlueLightDiet Imho, no concerns if step by step. The partially "Nordic" DNA and mtDNA heritage gives you tremendous metabolic flexibility that others lack. The genetic admixture is highly divergent among humans, and most of the Indo-Europeans don't even realize how blessed they are.
Metabolic flexibility isn't about diet wars. It's about cellular capacity. Resistance training improves glucose uptake independent of weight loss. Train the machinery.
#BrownAdiposeTissue (BAT) plays a role in #thermogenesis & energy homeostasis. This study shows how signals from the #SuprachiasmaticNucleus coordinate metabolic flexibility of BAT, via an ADRB3-S100B signaling axis, with therapeutic implications @plosbiology.org
Metabolic flexibility delays aging by reducing chronic inflammation.
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
#BrownAdiposeTissue (BAT) plays a role in #thermogenesis & energy homeostasis. This study shows how signals from the #SuprachiasmaticNucleus coordinate metabolic flexibility of BAT, via an ADRB3-S100B signaling axis, with therapeutic implications @plosbiology.org
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
Unlock your ultimate endurance potential!
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
@georgediano When one fasts for 16 hrs the body enters metabolic switching from sugar to Glycogen then KETONED. Ketones provide efficient clean fuel for brain & body. Then metabolic flexibility & AUTOPHAGY sets in. If sustained insulin sensitivity improves and Type 2 Diabetes CAN REVERSE!
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
@degenerosity75 The inclusion of MOTS-c alongside NAD and metabolic peptides is interesting. Targeting mitochondrial function and metabolic flexibility can be a powerful longevity strategy.
@mitometest Mitochondrial peptides often act as crucial signaling molecules, influencing cellular energy regulation beyond direct ATP production. Their systemic effects on metabolic flexibility are fascinating.
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
5. Lower chronic inflammation 4. Improve mitochondrial efficiency and metabolic flexibility. 3. Increase aerobic capacity and VO₂max. 2. Restore sleep depth and circadian alignment. 1. Strengthen social safety, coherence, and meaning. Connection, Vitality, Clarity, Flow https://t.co/3EmGstgjld
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @PeterMShaw: Stay off the carbs to care for and feed your mitochondria
Stay off the carbs to care for and feed your mitochondria
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
@barefoot_anarch Intriguing synthesis—Nanji & French (1989) indeed found fish oil exacerbated ethanol-induced liver damage in rats vs. saturated fats like tallow. Historical high-carb diets (e.g., Kitavans) thrived without PUFAs overload. Low-carb as a "hack" aligns with metabolic flexibility
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
RT @spugh01: Insulin resistance starts as mitochondrial inflexibility, not simply “too much sugar.” Light → circadian timing → leptin → e…
@the_no_mind @brandlytics (Apologies for cutting to the chase) 'Prevention comes down to one principle: Stop breaking EZ water. Start building it. How? Sunlight. Sauna. Grounding. Circadian Alignment. Metabolic flexibility. ANS balance. Low oxidative stress.' (Thanks! Am bookmarking.)
Sugar cravings are not a lack of willpower. They are a "Mitochondrial Energy Crisis." When your cells cannot efficiently access stored body fat for fuel, they scream for quick glucose to survive. You don't need "discipline." You need Metabolic Flexibility.
8 ways to build metabolic flexibility • Time-restricted eating • Protein prioritization • Movement after meals • Strength training • Zone 2 cardio • Adequate sleep • Stress management • Gradual carb timing optimization The ability to efficiently utilize different fuel sources is central to sustain
Manipulating microbial metabolic flexibility for climate-smart biotechnological applications in agriculture doi.org/10.1071/MA25...
Intermittent fasting enhances lifespan and healthspan by boosting stress‑response pathways, metabolic flexibility, and autophagy. It improves insulin sensitivity, supports mitochondria, and reduces inflammation—building resilience against chronic diseases. #IntermittentFasting #Aging #Healthspan
Eating when the body signals hunger fosters metabolic flexibility and self-awareness—an approach that aligns biology with behavior. This shifts the focus from external control to internal awareness—eating not because the clock says so, but because the body signals readiness. #IntermittentFasting
We also highlight emerging evidence that these states are maladaptive but potentially REVERSIBLE, positioning metabolic flexibility as a promising therapeutic target in AD.
Join us Wednesday, November 12, at 1 pm ET, for a @hsphniehsctr.bsky.social and @harvardenvhealth.bsky.social seminar with Dr. Will Mair @willmair.bsky.social on Metabolic flexibility and healthy aging. In-person and virtual! Visit hsph.me/niehs-seminar for more info and Zoom registration.
Friendly reminder #QuackMalone opted to be on ACIP and not getting a salary or honorarium by the gov. So what does our quack on ACIP do to make a buck? He hypes this shit on his "Malone.news" Substack but puts most of his bullshitting behind a paywall.
Metabolic flexibility is your body’s ability to switch between fat and sugar for fuel. Stress, sleep loss, and restriction lock it in “storage” mode.
Metabolic flexibility gives you freedom to train and recover without crashing. Try varying your eating habits and rotating through periods of higher carbs then periods of higher fats. Try varying the length of time between the last meal of one day and the first of the next.
Metabolic Flexibility Your body’s real superpower is burning fats or carbs, but switching between them effortlessly. The healthiest people aren’t *strictly* keto, vegan, or paleo. They were our ancestors before the agricultural revolution who had no choice but eat with the changing seasons.
Among research participants with metabolic syndrome, those who successfully reduced sedentary time by at least half an hour showed improvements in metabolic flexibility and fat burning during light-intensity exercise compared to those who remained highly sedentary.
Your body has two fuel tanks: sugar & fat A healthy metabolism switches between them easily But inflammation makes you burn sugar 24/7. You can't access fat stores. Always hungry. Energy crashes Restore metabolic flexibility. Fix the inflammation. Unlock fat burning
Your body is not a math equation. A healthy woman with muscle mass, proper hormone function, and metabolic flexibility will often weigh more than these arbitrary standards suggest. Muscle is denser than fat. Bone density matters. Your frame size is unique.
The research is crystal clear: muscle mass, metabolic flexibility, and cognitive function don't have to decline precipitously with age...they decline precipitously with neglect.
This strategy maximizes bioenergetic yields and allows M. extorquens SLI 505 to grow on aromatic acids without accumulating toxic formaldehyde. The study highlights the metabolic flexibility and robustness of M.
#ISEH2025 Two posters from our lab tonight at the poster session: #3171 by Célia Sergi showing how metabolic reprogramming in the niche is required for emergency myelopoiesis during infection! #3113 by myself on how protein palmitoylation controls metabolic flexibility in AML!
The real benefit of intermittent fasting? It trains your body to rely on fat stores for fuel. This shift improves metabolic flexibility, fat burning, and energy efficiency. It’s less about skipping meals — more about improving how your body functions.
Online now: Perspectives on whole body and tissue-specific metabolic flexibility and implications in cardiometabolic diseases
New in @nature.com: "The Kenyan cohort had higher #carbohydrate oxidation and improved metabolic flexibility that was associated with consumption of a healthy diet comparably low in fat and high in slowly digestible #carbohydrates."
(BioRxiv All) Metabolic Flexibility of Microglia: Energy Substrate Utilization and Impact on Neuronal Metabolism: Microglia, the main resident immune cells of the brain, play critical roles in maintaining neuronal function and homeostasis. Microglia metabolic flexibility… #BioRxiv #MassSpecRSS
Metabolic Flexibility of Microglia: Energy Substrate Utilization and Impact on Neuronal Metabolism https://www.biorxiv.org/content/10.1101/2025.09.18.676073v1
Metabolic Flexibility of Microglia: Energy Substrate Utilization and Impact on Neuronal Metabolism https://www.biorxiv.org/content/10.1101/2025.09.18.676073v1
Your metabolism doesn't care about your summer vacation. It cares about consistency, strength training, and metabolic flexibility.
Tripartite ER-Mitochondria-Lipid Droplets contact sites control adipocyte metabolic flexibility www.biorxiv.org/content/10.1...
This review focuses on myocardial metabolic inflexibility in cardiometabolic disease and heart failure with preserved ejection fraction (HFpEF) and discusses potential therapies aimed at improving metabolic flexibility for the treatment of HFpEF.
Tripartite ER-Mitochondria-Lipid Droplets contact sites control adipocyte metabolic flexibility https://www.biorxiv.org/content/10.1101/2025.09.16.676493v1
Tripartite ER-Mitochondria-Lipid Droplets contact sites control adipocyte metabolic flexibility https://www.biorxiv.org/content/10.1101/2025.09.16.676493v1
Looking forward to an exciting @sfb1348.bsky.social seminar with Stefanie Schirmeier @tudresden.bsky.social on September 18. She will speak about "Metabolic flexibility of the nervous system". More info: www.uni-muenster.de/SFB1348/en Everyone's welcome!
Excited to see this paper in press. The result of a decade (!!) long conversation with Philipp about insect's profound metabolic solutions to the challenges of life... Metabolic Flexibility in Insects: Patterns, Mechanisms, and Implications | Annual Reviews - www.annualreviews.org/content/jour...
Orangutans demonstrate metabolic flexibility by adjusting their diet and activity in response to food availability, maintaining health and avoiding obesity despite fluctuating resources. doi.org/g9znbd
Does the Keto Diet Actually Work? https://www.newsbeep.com/uk/76777/ For the average person looking to build metabolic flexibility, the cyclical approach leverages all the benefits of the…
Does the Keto Diet Actually Work? https://www.newsbeep.com/au/78511/ For the average person looking to build metabolic flexibility, the cyclical approach leverages all the benefits of the…
Does the Keto Diet Actually Work? https://www.newsbeep.com/us/92865/ For the average person looking to build metabolic flexibility, the cyclical approach leverages all the benefits of the…
Activated human NK cells cannot synthesize serine & are impaired when serine starved Mouse NK cells synthesize serine to fuel one-carbon metabolism & proliferation for increased metabolic flexibility @natmetabolism.nature.com www.nature.org/articles/s42...
Successfully reducing daily sitting by at least half an hour may improve metabolic flexibility. @utu.fi onlinelibrary.wiley.com/doi/10.1111/...
Huge thank you to John Whittle from UCL for joining @acumpstey.bsky.social on @topmedtalk.bsky.social at the EBPOM Global World Congress in #London to explain the importance of #metabolic #flexibility,its impact on #postoperative #complications & importance in #perioperative #care. rb.gy/2lnxp9
Tartrate-resistant acid phosphatase 5 regulates the metabolic flexibility of macrophages in the tumor microenvironment, thereby influencing their functional fate and modulating tumor growth #SingleCell
Ever feel like your energy just doesn’t bounce back like it used to? It’s not just age. It's your cells losing their metabolic flexibility. Good news: we’re learning how to reverse it.
Peatland microbes resist warming, with stable communities and diverse carbon pathways; methanogens show metabolic flexibility but are not dominant. #MicroSky www.nature.com/articles/s41...
Woohoo! Latest preprint from the lab describing how fibroblasts can use alanine to bypass glutamine requirements for differentiation and ECM production. It's a lovely example of metabolic flexibility with implications for how we study cell metabolism. Shout out to Fei Li, who led this work! #cureipf
More compelling Promethion powered research from Dr. J McCarthy & colleagues at University of Kentucky - microRNA 1 loss rewires skeletal muscle pyruvate metabolism, limiting metabolic flexibility.
Comparison of mitochondrial metabolism in songbird subspecies, before and after an artificial heatwave, shows that metabolic flexibility and energy production are unevenly impacted: Pacheco-Fuentes et al. @cecooper.bsky.social @danielmhooper.bsky.social doi.org/10.1093/jeb/...
The mevalonate pathway of isoprenoid biosynthesis supports metabolic flexibility in Mycobacterium marinum https://www.biorxiv.org/content/10.1101/2025.07.11.664281v1
The mevalonate pathway of isoprenoid biosynthesis supports metabolic flexibility in Mycobacterium marinum https://www.biorxiv.org/content/10.1101/2025.07.11.664281v1
This is groundbreaking! Harnessing metabolic flexibility to help engineered immune cells thrive using fructose in the tumor environment is a brilliant strategy. Huge kudos to Schild et al. for pushing cancer immunotherapy forward with such innovative work!
Sooo apparently all of the above is actually related to a concept called metabolic flexibility, and it does seem that for some reason higher estrogen states are an off switch for mine.
3 advantages of the backfill eating pattern: 1) Higher energy during the day from less food 2) Better sleep from carb overload at night 3) Metabolic flexibility - body learns to run on fat in morning, carbs at night.
We had the pleasure of having Sylvain Giroud as a speaker for a #WilhelminenbergSeminarTalk and he gave us insights into early-life metabolic flexibility and its lifelong and intergenerational effects in a small hibernator
Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) pmc.ncbi.nlm.nih.gov/articles/PMC...
•T cells exhibit metabolic flexibility allowing environmental adaptation. •Compartmentalization of acetyl-CoA generation is critical for T cell function. •Nuclear intermediate metabolites drive chromatin remodelling. www.sciencedirect.com/science/arti...
Diatoms do DNRA and thrive in the dark, anoxic, sulfidic sediments of Lake Fryxell (the Golden Meadows of Lake Fryxell) - amazing metabolic flexibility to occupy so many ecological niches! Great talk by Elisa Mertz at #MLD8
We hope our findings will spur future studies to clarify how these enzymes and the regulation of 4-HAs underlie human health and disease. There is much to learn about how 4-HAs contribute to whole body metabolic flexibility and their tissue- and organelle-specific functions!
Open Access UCL Research: Effects of Preoperative High-intensity Training on Metabolic Flexibility discovery.ucl.ac.uk/id/eprint/10...
Love learning about metabolic flexibility! A breath device to see my fuel source? So cool for boosting energy. #BodyScience #FeelGood
New #MolMetabolism paper: microRNA-1 Regulates Metabolic Flexibility by Programming Adult Skeletal Muscle Pyruvate Metabolism. #Myoblue tinyurl.com/2uxm46u5
Impressive lesson from @pgonzalezrodriguez.bsky.social @MitoNed.bsky.social at #cursonacionalneurociencia in Carmona about her findings that changed textbooks on metabolic flexibility of dopaminergic neurons in neurodegenerative that underlies Parkinson's disease.
microRNA-1 Regulates Metabolic Flexibility by Programming Adult Skeletal Muscle Pyruvate Metabolism www.sciencedirect.com/science/arti...
A tour de force! Mouse, worm, and human data all telling the same story. Amazing! “microRNA-1 Regulates Metabolic Flexibility by Programming Adult Skeletal Muscle Pyruvate Metabolism” www.sciencedirect.com/science/arti...
#BretGoodPasterPhD speaks to us about intramyocellular lipids and insulin resistance and a VERY fascinating concept of metabolic flexibility:
Dr. Oz: “Buy this miracle cure!” RFK Jr.: “The cure is worse than the disease!” Casey Means: “Actually, the cure is metabolic flexibility and this $299 sensor patch.”
Dr. Oz: “Buy this miracle cure!” RFK Jr.: “The cure is worse than the disease!” Casey Means: “Actually, the cure is metabolic flexibility and this $299 sensor patch.”
PFKFB2 is Pivotal for Metabolic Flexibility and Differential Glucose Utilization https://www.biorxiv.org/content/10.1101/2025.05.26.656235v1
PFKFB2 is Pivotal for Metabolic Flexibility and Differential Glucose Utilization https://www.biorxiv.org/content/10.1101/2025.05.26.656235v1
Seasonal transcriptomic shifts reveal metabolic flexibility of chemosynthetic symbionts in an upwelling region journals.asm.org/doi/full/10.... #jcampubs
New paper out showcasing the metabolic flexibility of a marine symbiosis in response to environmental changes driven by seasonal upwelling — beautifully led by @isimorel.bsky.social at @mpimarinemicrobio.bsky.social
To me, it's telling that even strains that have evolved separately for a long time coexist readily (see FMT study below). I feel this strongly implicates physiological/metabolic flexibility, rather than fixed niche differentiation, as a driver of coexistence www.science.org/doi/10.1126/...
The glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibility. https://www.biorxiv.org/content/10.1101/2025.05.12.652188v1
The glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibility. https://www.biorxiv.org/content/10.1101/2025.05.12.652188v1
Osteocyte Differentiation Requires Glycolysis, But Mature Osteocytes Display Metabolic Flexibility https://www.biorxiv.org/content/10.1101/2025.05.09.652291v1
Osteocyte Differentiation Requires Glycolysis, But Mature Osteocytes Display Metabolic Flexibility https://www.biorxiv.org/content/10.1101/2025.05.09.652291v1
Met32 governs transcriptional control of sulfur metabolic flexibility and resistance to reactive sulfur species in the human fungal pathogen Candida albicans https://www.biorxiv.org/content/10.1101/2025.05.12.653471v1
Met32 governs transcriptional control of sulfur metabolic flexibility and resistance to reactive sulfur species in the human fungal pathogen Candida albicans https://www.biorxiv.org/content/10.1101/2025.05.12.653471v1
JMIR Res Protocols: Metabolic Flexibility to Predict Lifestyle Interventions Outcomes (MEPHISTO): #Protocol for Predictive Validation #Study and #RCT #ClinicalTrial
Nice summary of the low-carb keto approach to eating healthily: "The modern keto mindset is less rigid, less about fast fat loss, and more about metabolic flexibility. It’s a tool, not a lifestyle religion." www.latimes.com/live-well/we...
Thank you for tolerating me Rhonda Patrick. Theory and invocation are both their own sets of spicy meatballs.
Open Access UCL Research: Metabolic Flexibility as a Candidate Mechanism for the Development of Postoperative Morbidity discovery.ucl.ac.uk/id/eprint/10...
Open Access UCL Research: Prehabilitation- Do we need metabolic flexibility discovery.ucl.ac.uk/id/eprint/10...
• Increased aerobic capacity • Enhanced fat oxidation • Improved metabolic flexibility • Reduced risk of overtraining #EnduranceTraining #Running #Ultrarunning #MetabolicHealth #PerformanceScience #LeadWellLiveWell
During diet-induced #obesity in mice, skeletal muscle BMAL1 is an important regulator of HIF-driven glycolysis and metabolic flexibility, which influences the development of high-fat-diet-induced glucose intolerance @pnas.org www.pnas.org/doi/10.1073/...
RESEARCH | Y Wang, H Xie, Q Liu, CY Wang et al. (HUST, CN) #Kdm2a demethylates #H3K36me2 to mediate fast-to-slow-twitch #myofiber transition and reshape #SkeletalMuscle metabolic flexibility under #metabolic stress conditions
Seminar alert!
Schild et al. take advantage of the availability of fructose in the tumor microenvironment. Engineered immune cells can use metabolic flexibility and leverage fructose as a nutrient source to fuel their metabolism and facilitate function in vivo. www.cell.com/cancer-cell/...
Want to learn more about metabolic flexibility? Read the full article here: rollingout.com/2025/02/27/m...
Is Your Metabolism Stuck? Your body’s ability to switch between burning carbs and fats—aka metabolic flexibility—is key to balanced insulin, stable energy, and better overall health. But how do you know if your metabolism is working for or against you? You can find out with a #HealthyLifestyleCheck
The body likes metabolic flexibility through fasting, but only when it is getting adequate protein and nutrients when NOT in a fasted state. Work smarter not harder! Don’t set yourself up for failure by incorporating the right health tools in the wrong ways!
Engineered metabolic flexibility in immune cells leverages availability of fructose in tumor microenvironment to fuel their function in vivo www.cell.com/cancer-cell/... @cp-cancercell.bsky.social
Your Search Is Over — We Are Redefining Healthcare for Longevity, Metabolic Flexibility, and Neuroprotection
At MetaboLab, we’re proud to lead the way with Medicine 3.0 – an innovative, holistic approach that goes beyond symptom management to focus on longevity, metabolic flexibility, and neuroprotection.
•Exercise-timing promotes divergent metabolic adaptations in lean and obese mice •Late dark phase exercise resulted in a greater reduction in body weight gain •Late dark phase exercise promotes metabolic flexibility & insulin sensitivity •Enhanced Pdk4 expression following late dark phase exercise
4. Crisis Negotiation at the Water Cooler: Navigated an excruciatingly long chat with Greg from accounting about his intermittent fasting journey. Smiled. Nodded. Pretended I, too, yearn for metabolic flexibility.
Your body is amazingly flexible. Maybe not in a touch-your-toes-from-standing kind of way, but deep inside at the cellular level. This metabolic flexibility enables your body to fuel itself using different kinds of macronutrients such as carbohydrates or fats. www.alive.com/health/metab...
What could possibly go wrong?
a) We are massive sugar-burners with very poor metabolic flexibility b) We are chronically over-stressed in a state of a perpetually cranking sympathetic nervous system.
After drinking a protein shake, blood glucose and insulin levels in those with and without family history is the same, but metabolic flexibility is lower in diabetics and those without diabetes who have a family history (F) than those without diabetes with no family history
Metabolic flexibility is the degree to which you can shift between burning carbs and fats. Folks with diabetes and insulin resistance are less metabolically flexible. You may be able to detect a decrease in metabolic flexibility before insulin resistance occurs.
Epigenetics Update - Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity bit.ly/3WDgKQN A Nature Metabolism article supports Kdm2a as a viable target against metabolic stress #Epigenetics #Metabolism #Stress --- High-res insight without cell sorting; epigenome.us
Recipe adjustment 'Thus, hyperglycemic culture conditions promote expansion at the expense of metabolic flexibility and suggest pharmacologic metabolic rewiring as a beneficial strategy for improvement of cellular immunotherapies.' #Immunology #Immunotherapy www.cell.com/cell-metabol...
Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity www.nature.com/articles/s42...
New #NatMetabolism paper: Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity. #MyoBlue tinyurl.com/2nxfhtup
The newly identified microbes, part of the ancient Bathyarchaeia group, exhibit remarkable metabolic flexibility, thriving in oxygen-poor environments, consuming carbon monoxide, and contributing to methane production.
Metabolic flexibility https://t.co/t0g6Bzr43q
https://t.co/FaPpgx6g3T Por último, cada vez está más claro que la reducción de la capacidad de uso de combustible en, por ejemplo, el músculo esquelético, indicada por la reducción del tamaño y la densidad mitocondriales, es característica del estado de síndrome metabólico y
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