PubHawk
September 2004 PMID 15296705

Low-density lipoprotein particle number and risk for cardiovascular disease.

William C Cromwell, James D Otvos

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Mentions

33
Peak: 8 in Sep 2022
across 4 sources since Feb 2021

Extended reach

1,816,619
potential audience

Total likes

31,864

Video views

1,717,484

Mentions per month

Feb 2021 – May 2023

Where it's discussed

  • X / Twitter23 posts
  • YouTube6 videos
  • News2 articles
  • Blogs2 articles

AI synopsis

What people are saying

The collective discussions highlight a nuanced debate about LDL particle measurement, with some posters emphasizing its importance and others dismissing its relevance, using technical language and referencing studies to support claims, which reflects a high level of engagement and moderate perceived impact in shaping health perspectives.

AgreementNeither agree nor disagree

The discussions show mixed opinions, with some dismissing the research and others supporting the link between lipid markers and cardiovascular risk.

InterestModerate interest

Participants demonstrate moderate curiosity, especially regarding the relationship between LDL particle number and heart disease.

EngagementHigh engagement

Posts involve detailed explanations, references, and debates about the methodologies and implications, indicating deep engagement.

ImpactModerate impact

The conversations suggest the article influences opinions, prompting debates about measurement techniques and clinical significance.

Abstract in brief

  • Low-density lipoprotein (LDL) particles play a key role in causing coronary heart disease (CHD), and reducing LDL levels benefits high-risk patients.
  • There's controversy over whether current LDL measurements are the best way to identify all people who need therapy, especially since small LDL particles are linked with higher CHD risk but also come with more LDL particles overall.
  • Research indicates that measuring LDL particle number, particularly through nuclear magnetic resonance, is a more reliable and independent predictor of CHD risk than just measuring LDL cholesterol or particle size.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Nick
@upRootNutrition · X

1/8 No problem!

Sep 24, 2022 · 28 likes · 8 shares · 9,507 followers View post →
Nick
@upRootNutrition · X

LDL-C or LDL-P/ApoB? A high TG/HDL ratio is a correlate for elevated LDL-P/ApoB, and LDL-C's effects on increasing CVD risk almost never survives adjustment for LDL-P/ApoB in multivariable adjustment models.

May 29, 2021 · 13 likes · 3 shares · 9,507 followers View post →
Nick
@upRootNutrition · X

2/10 Philip's focus on "metabolic health" over "LDL" is misguided. High TG and low HDL is a proxy for ApoB/LDLp. If you have high ApoB in the context of low TG and high HDL, you're likely still at risk. ApoB tracks tightly with atherogenic dyslipidemia. https://t.co/htHMTV65Q0 https://t.co/ukqxOh0xTJ

May 23, 2022 · 9 likes · 9,507 followers View post →
Nick
@upRootNutrition · X

Bonus reference, here. The TG/HDL ratio is basically just a correlate for a higher LDL particle count in the general population. Just because keto might lower TG, that shouldn't be taken as an indication that keto would abolish the risk. https://t.co/htHMTV65Q0 https://t.co/VJHNZLkizs

Jul 16, 2022 · 5 likes · 9,507 followers View post →
Nick
@upRootNutrition · X

@Springandashura It's a proxy for ApoB under usual circumstances. However, keto can have the effect of dropping TGs and increasing HDL-C, but ALSO increasing ApoB. So it's unclear that keto is even beneficial at all in this regard. https://t.co/htHMTV65Q0 https://t.co/DyFT1sWkVx

Jun 20, 2022 · 3 likes · 9,507 followers View post →
Nick
@upRootNutrition · X

Reference: https://t.co/htHMTUOuYs

Jun 6, 2021 · 2 likes · 9,507 followers View post →

All mentions

Henry
@henrylegion · X

@s4m4rn0ld @JWiseWrld @AddyMuncher @nutrition_facts “90 seconds” Doesn’t refute my point. That’s called confirmation bias. It's untrue that LDL tells you nothing. That's just a complete misunderstanding. LDL-C and ApoB are very rarely discordant outside of the range of atherogenic dyslipidemia. https://t.co/NO3uAnJCWX

Apr 11, 2023 · 122 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @TheNutrivore: 1/8 No problem!

Dec 4, 2022 · 8 shares · 1,368 followers View post →
Tom Babington
@Tom_Babington1 · X

RT @TheNutrivore: 1/8 No problem!

Sep 25, 2022 · 8 shares · 1,204 followers View post →
Simon Brežan MD
@BrezanSimonMD · X

RT @TheNutrivore: 1/8 No problem!

Sep 25, 2022 · 8 shares · 780 followers View post →
Calipso
@calipso_shots · X

RT @TheNutrivore: 1/8 No problem!

Sep 24, 2022 · 8 shares · 30 followers View post →
Matthew Nagra, ND
@drmatthewnagra · X

RT @TheNutrivore: 1/8 No problem!

Sep 24, 2022 · 8 shares · 3,140 followers View post →
Aaron Lepeska
@AaronLepeska · X

RT @TheNutrivore: 1/8 No problem!

Sep 24, 2022 · 8 shares · 188 followers View post →
Patrick Elliott, BSc, MPH
@PatrickElliott0 · X

RT @TheNutrivore: 1/8 No problem!

Sep 24, 2022 · 8 shares · 895 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @TheNutrivore: 1/8 No problem!

Sep 24, 2022 · 8 shares · 1,368 followers View post →
Nick
@upRootNutrition · X

1/8 No problem!

Sep 24, 2022 · 28 likes · 8 shares · 9,507 followers View post →
Nick
@upRootNutrition · X

Bonus reference, here. The TG/HDL ratio is basically just a correlate for a higher LDL particle count in the general population. Just because keto might lower TG, that shouldn't be taken as an indication that keto would abolish the risk. https://t.co/htHMTV65Q0 https://t.co/VJHNZLkizs

Jul 16, 2022 · 5 likes · 9,507 followers View post →
Nick
@upRootNutrition · X

@Springandashura It's a proxy for ApoB under usual circumstances. However, keto can have the effect of dropping TGs and increasing HDL-C, but ALSO increasing ApoB. So it's unclear that keto is even beneficial at all in this regard. https://t.co/htHMTV65Q0 https://t.co/DyFT1sWkVx

Jun 20, 2022 · 3 likes · 9,507 followers View post →
Nick
@upRootNutrition · X

2/10 Philip's focus on "metabolic health" over "LDL" is misguided. High TG and low HDL is a proxy for ApoB/LDLp. If you have high ApoB in the context of low TG and high HDL, you're likely still at risk. ApoB tracks tightly with atherogenic dyslipidemia. https://t.co/htHMTV65Q0 https://t.co/ukqxOh0xTJ

May 23, 2022 · 9 likes · 9,507 followers View post →
Nick
@upRootNutrition · X

@JonInternet It's untrue that LDL tells you nothing. That's just a complete misunderstanding. LDL-C and ApoB are very rarely discordant outside of the range of atherogenic dyslipidemia. Again, I do not have atherogenic dyslipidemia. https://t.co/htHMTUOuYs https://t.co/RJ4xYRmtML

Mar 2, 2022 · 1 like · 9,507 followers View post →
Nick
@upRootNutrition · X

Reference: https://t.co/htHMTUOuYs

Jun 6, 2021 · 2 likes · 9,507 followers View post →
Aaron Lepeska
@AaronLepeska · X

RT @The_Nutrivore: LDL-C or LDL-P/ApoB? A high TG/HDL ratio is a correlate for elevated LDL-P/ApoB, and LDL-C's effects on increasing CVD…

Jun 3, 2021 · 3 shares · 188 followers View post →
Matías
@Matas53795263 · X

RT @The_Nutrivore: LDL-C or LDL-P/ApoB? A high TG/HDL ratio is a correlate for elevated LDL-P/ApoB, and LDL-C's effects on increasing CVD…

May 29, 2021 · 3 shares · 7 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @The_Nutrivore: LDL-C or LDL-P/ApoB? A high TG/HDL ratio is a correlate for elevated LDL-P/ApoB, and LDL-C's effects on increasing CVD…

May 29, 2021 · 3 shares · 1,368 followers View post →
Nick
@upRootNutrition · X

LDL-C or LDL-P/ApoB? A high TG/HDL ratio is a correlate for elevated LDL-P/ApoB, and LDL-C's effects on increasing CVD risk almost never survives adjustment for LDL-P/ApoB in multivariable adjustment models.

May 29, 2021 · 13 likes · 3 shares · 9,507 followers View post →
Nick
@upRootNutrition · X

@aware_crackbear @dylanarmbruste3 @foodbeforepills @mosca_matthew I'm not convinced the TG/HDL ratio would really survive an adjustment for ApoB/LDLp at the end of the day. Perhaps some residual risk from TG, but probably not much by comparison. https://t.co/htHMTV65Q0 https://t.co/nrfHbddwzi

May 29, 2021 · 9,507 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @The_Nutrivore: @DrPaulMason @dylanarmbruste3 @TheBhupiThakur @StolteThiago @Tom_Babington1 @DrMavro @NutritionMadeS3 @AviBittMD I'm not…

Apr 20, 2021 · 2 shares · 1,368 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @The_Nutrivore: @DrPaulMason @dylanarmbruste3 @TheBhupiThakur @StolteThiago @Tom_Babington1 @DrMavro @NutritionMadeS3 @AviBittMD I'm not…

Feb 27, 2021 · 2 shares · 1,368 followers View post →
Nick
@upRootNutrition · X

@DrPaulMason @dylanarmbruste3 @TheBhupiThakur @StolteThiago @Tom_Babington1 @DrMavro @NutritionMadeS3 @AviBittMD I'm not sure why the author's expectations should be taken as direct evidence of anything. But the effect of lowering HDL and increasing TG on CVD risk is a function of ApoB. The TG/HDL ratio is merely a correlate for ApoB. https://t.co/htHMTV65Q0

Feb 27, 2021 · 1 like · 2 shares · 9,507 followers View post →